Transdermal iontophoretic delivery of dopamine agonists: in vitro - in vivo correlation based on novel compartmental modeling

Transdermal iontophoretic delivery of dopamine agonists: in vitro - in vivo correlation based on novel compartmental modeling

Nugroho, A.K.

Citation

Nugroho, A. K. (2005, May 11). Transdermal iontophoretic delivery of dopamine agonists:

in vitro - in vivo correlation based on novel compartmental modeling. Retrieved from

https://hdl.handle.net/1887/2316

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the_{Institutional Repository of the University of Leiden} Downloaded from: https://hdl.handle.net/1887/2316

TRANSDERMAL I

ONTOPHORETI

C

DELI

VERY

OF

DOPAMI

NE

AGONI

STS:

IN VITRO - IN VIVO

CORRELATI

ON

TRANSDERMAL IONTOPHORETIC DELIVERY

OF DOPAMINE AGONISTS:

IN VITRO - IN VIVO CORRELATION

BASED ON NOVEL COMPARTMENTAL MODELING

Proefschrift

Ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector M agnificus Dr. D.D. Breimer,

hoogleraar in de faculteit der W iskunde en Natuurwetenschappen en die der Geneeskunde, volgens besluit van het College voor Promoties

te verdedigen op woensdag 11 M ei 2005 klokke 14.15 uur

door

Akhmad Kharis Nugroho

Promotores: Prof. dr. J.A. Bouwstra Prof. dr. M. Danhof

Referent: Prof. dr. V. Préat-Haine

(Unité Pharmacie Galénique, Université Catholique de Louvain, Bruxelles Belgium)

Overege Leden: Prof. dr. G.J. Mulder

Drug Delivery Technology, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands and at the Department of M edicinal Chemistry, University Center of Pharmacy, University of Groningen, Groningen, The Netherlands.

This project was financially supported by QUE (Quality for Undergraduate Education) project Batch III year 2000 – 2004, Faculty of Pharmacy, Gadjah M ada University, Yogyakarta, Indonesia.

Akhmad Kharis Nugroho

Transdermaliontophoretic delivery of dopamine agonists: In vitro - in vivo correlation based on novel compartmental modeling

TABLE OF CONTENTS

Part A. General introduction

Chapter 1 Current progress in Parkinson’s disease therapy with dopamine agonists: The role of transdermal iontophoretic delivery

1

Chapter 2 Scopes and intent of the investigations of the thesis 33 Part B. In vitro optimization of transdermal iontophoretic delivery of

dopamine agonists rotigotine and 5-OH-DPAT Chapter 3 Transdermal iontophoresis of rotigotine across human

stratum corneum in vitro: influence of pH and NaCl concentration

37

Chapter 4 Transdermal iontophoresis of rotigotine: influence of concentration, temperature and current density in human skinin vitro

55

Chapter 5 Transdermal iontophoresis of the dopamine agonist 5-OH-DPAT in human skin in vitro

69

Part C. The development and application of novel compartmental models for transdermal iontophoretic transport in vitro and in vivo

Chapter 6 Compartmental modeling of transdermal iontophoretic transport: I. In vitro model derivation and application

87 Chapter 7 Compartmental modeling of transdermal iontophoretic

transport: II. In vivo model derivation and application

109 Chapter 8 Pharmacokinetics and pharmacodynamics analysis of

transdermal iontophoresis of 5-OH-DPAT in rats: In vitro – in vivo correlation

131

Chapter 9 The extended compartmental models of transdermal iontophoretic transport in vitro and in vivo

155

Part D. Summary and future perspectives

Chapter 10 Summary and future perspective 177

Chapter 11 Samenvatting en toekomstperspectieven 191

Acknowledgements 205

Curriculum Vitae 207