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Cover Page The handle http://hdl.handle.net/1887/83274 holds various files of this Leiden University dissertation. Author: Jonkman, K. Title: Ketamine pharmacology revisited Issue Date: 2020-01-28

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Cover Page

The handle

http://hdl.handle.net/1887/83274

holds various files of this Leiden University

dissertation.

Author: Jonkman, K.

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Ketamine pharmacology revisited

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Ketamine pharmacology revisited

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,

volgens besluit van het College voor Promoties te verdedigen op dinsdag 28 januari 2020

klokke 13:45 uur

door

Kelly Jonkman

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Promotor Prof. Dr. A. Dahan Co-promotor Dr. M. van Velzen

Leden promotiecommissie Prof. Dr. L.P.H.J Aarts Dr. E.Y. Sarton Dr. M. Niesters

Prof. Dr. N. Van der Wee

Prof. Dr .M.W. Hollmann (Academisch centrum Amsterdam)

Prof. Dr. C.A.J. Knibbe (St. Antonius ziekenhuis)

ISBN: 978-94-028-1882-6 Cover design by Jesse Nortier

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CONTENTS

Chapter 1 General introduction 9

Chapter 2 Ketamine for pain 17

Chapter 3 Inhaled ketamine: evaluation of safety and efficacy in healthy volunteers

33

Chapter 4 Pharmacokinetics and bioavailability of inhaled ketamine in healthy volunteers

47

Chapter 5 Esketamine counters opioid-induced respiratory depression 65 Chapter 6 Differential role of nitric oxide in the psychedelic symptoms induced

by racemic ketamine and esketamine in human volunteers

91

Chapter 7 Summary and conclusions 111 Chapter 8 Samenvatting en conclusie 119

Addenda Curriculum Vitae 127

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