University of Groningen
Genotype-phenotype relationships and their clinical implications in inflammatory bowel
disease and type 2 diabetes
Abedian, Shifteh
DOI:
10.33612/diss.145919489
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Abedian, S. (2020). Genotype-phenotype relationships and their clinical implications in inflammatory bowel disease and type 2 diabetes. University of Groningen. https://doi.org/10.33612/diss.145919489
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Shifteh Abedian
Groningen, 25 November 2020
1- The rapid rise of Inflammatory Bowel disease (IBD) incidence in Asia reveals the importance of a changing environment, suggesting the possi-bility of gene-environment interaction in its pathogenesis. (This thesis). 2- A genetic risk score is not a strong predictor for Crohn’s Disease, and Ulcerative colitis in East and Central Asians. (This thesis).
3- Much work is needed to identify genetic factors associated with sub-clinical phenotypes and disease outcomes of IBD, especially in non-Euro-pean populations. (This thesis).
4- Cardiovascular disease, eye diseases and cancer are among the most com-mon comorbidities associated with Type 2 Diabetes (T2D). (This thesis). 5- Insulin remains an important part of treatment for T2D, even in combina-tion with Thiazolidine. (This thesis).
6- Standard guidelines for disease management may not be effective for all within the heterogeneous group of T2D patients. (This thesis).
7- It is now more important than ever time to start integrating genetic find-ings into routine clinical practice, to enable more personalized approach-es in managing IBD and T2D. (This thapproach-esis).
8- Great things happen to those who don’t stop believing, trying, learning, and being grateful. (Roy T. Bennett).
9- Life is really simple, but we insist on making it complicated. (Confucius). 10- Success is simple. Do what’s right, the right way, at the right time. (Ar-nold H. Glasow).
