• No results found

University of Groningen Brain perfusion SPECT analysis Sánchez Catasùs, Carlos Alfredo

N/A
N/A
Protected

Academic year: 2021

Share "University of Groningen Brain perfusion SPECT analysis Sánchez Catasùs, Carlos Alfredo"

Copied!
3
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

University of Groningen

Brain perfusion SPECT analysis Sánchez Catasùs, Carlos Alfredo

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Sánchez Catasùs, C. A. (2018). Brain perfusion SPECT analysis: New insights in mild cognitive impairment and neuromyelitis optica. University of Groningen.

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)

PROPOSITIONS

Belonging to the Ph.D. thesis “Brain Perfusion SPECT Analysis

New Insights in Mild Cognitive Impairment and Neuromyelitis Optica”

Carlos Alfredo Sánchez-Catasús

1. FDG-PET performs better than perfusion SPECT to predict AD dementia in MCI

individuals; however, the latter is a valid alternative when the former is not available –

this thesis, Chapter 2.

2. Changes in the topology of cerebrovascular reactivity in MCI may precede topographical

changes – this thesis, Chapter 3.

3. Graph theoretical analysis of brain perfusion SPECT has the potential to become a connectivity-based biomarker for MCI – this thesis, Chapter 4.

4. The integration of data from perfusion SPECT and structural MRI offers a more

comprehensive picture of NMO than either modality separately – this thesis, Chapter 5.

5. The number of optic neuritis attacks per patient is a potential confounder when

comparing NMO patients with controls, for both tissue volumes and perfusion by voxel-based statistical analysis – this thesis, Chapter 6.

6. “Make it simple” – Dr. Antoon Willemsen during supervision.

7. It is usually said that it is better to see the glass as half full rather than as half empty. In science, maybe it's better to see an almost empty glass.

(3)

8. Science and chess are similar in several aspects, but more than a war game, science is a growing puzzle that has to be assembled and disassembled over and over again.

9. In the Netherlands, a bike is "all you need". Then, "you can learn how to play the game"

– Paraphrasing the Beatles song “All you need is love".

10. “Happiness exists on earth and is obtained through the exercise of reason and serenity,

knowledge of full harmony of the universe and frequent practice of generosity” – José

Referenties

GERELATEERDE DOCUMENTEN

Brain Tissue Volumes and Perfusion Change with the Number of Optic Neuritis Attacks in Relapsing Neuromyelitis Optica: A Voxel-Based Correlation Study 183 Chapter 6. The Number

In recent years methods have been developed to study brain connectivity using neuroimaging [93, 94], one of which is based on graph theory (described below) that can be applied

split by time to conversion compared to the same group of control subjects. a) MRI (blue: atrophy) and FDG-PET (red: hypometabolism) results plotted onto an averaged brain.

Notably, these regions include the inferior parietal lobe bilaterally which also overlap with the regional CBF reduction in the MCI group in the basal condition (Fig. 3.C).Of

Furthermore, two other studies also showed that the global modularity increases in amnestic MCI patients, one using DTI (Daianu et al. 2014) and another by fMRI during a memory

Decreases of tissue volumes and perfusion with the increase of the number of optic neuritis attacks comprised extensive brain regions, including important components of the

This shows that the number of attacks ON attacks per patient in each group significantly influences the results, which highlights its confounder effect when comparing patients

In summary, chapters 5 and 6, using brain perfusion SPECT combined with voxel-based analysis, provide for the first time evidence that brain microvasculature is an early disease