From cardiogenesis to cardiac regeneration : focus on epicardium-derived cells Winter, E.M.

From cardiogenesis to cardiac regeneration : focus on epicardium-derived cells

Winter, E.M.

Citation

Winter, E. M. (2009, October 15). From cardiogenesis to cardiac regeneration : focus on epicardium-derived cells. Retrieved from https://hdl.handle.net/1887/14054

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

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Abbreviations

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2D two-dimensional

3D three-dimensional

a artery

A atrium

A anterior

Abs antibodies

AHF anterior heart field AMI acute myocardial infarction

Ang angiopoietin

ANOVA analysis of variance ANP atrial natriuretic peptide

Ao aorta

AP arterial pole

AR antigen retrieval

ASMA alpha smooth muscle actin α-SMA alpha smooth muscle actin

AUC area under the curve

AV atrioventricular

AVC atrioventricular cushion AVS atrioventricular sulcus bFGF basic fibroblast growth factor

BM bone marrow

BMC bone marrow-derived mononuclear cell BM-MNC bone marrow-derived mononuclear cell BMP bone morphogenic protein

BMSC bone marrow-derived multipotent stem cell

C coelomic cavity

CA coronary artery

CABG coronary artery bypass graft procedure

CC conductance catheter

CDC cardiac-derived stem cell

CM conditioned medium

CMc conditioned medium of cardiomyocyte progenitor cells CMe conditioned medium of epicardium-derived cells CMPC cardiomyocyte progenitor cell

CNC cardiac neural crest cell

CO cardiac output

CoT co-transplantation

CPC circulating progenitor cell cTnI cardiac troponin I cTnT cardiac troponin T

Cy-3 cyanine-3

DAB 3-3’ diaminobenzidine tetrahydrochloride DAPI 4’6-diamidine-2-phenylidole-dihydrochloride DDR2 discoidin domain receptor 2

DMSO dimethylsulfoxide

dP/dt_max maximal rate of left ventricular pressure increase - dP/dt_min maximal rate of left ventricular pressure decline DPTA diethlyenetriamine-pentaacetic acid

E elastance

202

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EC endothelial cell

EC endocardial cushion

ECG electrocardiogram

ECM extracellular matrix

ED end-diastole

EDP end-diastolic pressure

EDV end-diastolic volume

EDV_prsw,int intercept of the PRSW (preload recruitable stroke work) at specifi EDV (end-diastolic volume)

Eed end-diastolic elastance Ees end-systolic elastance

EF enforced

EF ejection fraction

eGFP enhanced green fluorescent protein ELISA enzyme-linked immunosorbent assay EMT epithelial-mesenchymal transformation

End/END endocardium

Ep/EP epicardium

Eph Ephrin receptor

EPC endothelial progenitor cell EPDC epicardium-derived cell

ES end-systole

ESC embryonic stem cell

ESP end-systolic pressure

ESPVR end-systolic pressure-volume relation

ESV end-systolic volume

ESVespvr,int intercept of ESPVR (end-systolic pressure-volume relation) at specific ESP (end-systolic pressure)

ET endothelin

F feet

FA flip angle

Fb fibroblast

FCS fetal calf serum

FGF fibroblast growth factor FGFR fibroblast growth factor receptor FHF first heart field

FITC fluorescein isthiocyanate FOG-2 friend of GATA-2

FOV field of view

G gut

Gd gadolinium

H heated

H head

HB-EGF heparin-binding epidermal growth factor-like growth factor hCMPC human cardiomyocyte progenitor cell

HE hematoxylin and eosin

hEPDC human epicardium-derived cell

HH Hedgehog

HH Hamburger Hamilton

HHF35 clone for α/γ muscle actin hMSC human mesenchymal stem cell

203

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HR heart rate

HRP horse radish peroxidase HSC hematopoietic stem cell HTU HeLa cell-transducing units

IFT inflow tract

IgG immunoglobulin G

IHC immunohistochemistry

IHD ischemic heart disease

INT intercept

iPS induced pluripotent cell

isl1 islet-1

IU infectious units

L left

LAD left anterior descending coronary artery

LoA limit of agreement

LV left ventricle / left ventricular LVEDV left ventricular end-diastolic volume LVEF left ventricular ejection fraction LVESV left ventricular end-systolic volume

LYVE lymphatic vessel endothelial hyaluronan receptor MACS magnetic cell sorting

MAPC multipotent adult progenitor cell

MASS magnetic resonance analytical software system MDR1 multi drug resistance

MF20 clone for sarcomeric myosin

MHC myosin heavy chain

MHC myosin heavy chain

MI myocardial infarction

MMP matrix metalloproteinase MOI multiplicity of infection

MR magnetic resonance

MRI magnetic resonance imaging mRNA messenger ribonucleic acid

MSC mesenchymal stem cell

MT Masson’s Trichrome

MTT 3-(4,5-dimethyolthiazol-2-yl)-2,5-diphenyl tetrazolium bromide

NC normalized photon count

NEX number of averages

NGS normal goat serum

NIH National Institute of Health

NOD/scid non-obese diabetic severe combined immunodeficient

NS not significant

OFT outflow tract

OT outflow tract

P pronase

P posterior

PBS phosphate buffered saline PCNA proliferating cell nuclear antigen PDGF platelet derived growth factor PDGFR platelet derived growth factor receptor

204

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PEO proepicardial organ

PFA paraformaldehyde

PHF posterior heart field

PHT primary heart tube

PlGF placental growth factor PRSW preload recruitable stroke work PRSWR preload recruitable stroke work relation

PV pressure volume

p-value probability value

qPCR quantitative polymerase chain reaction

R correlation coefficient

R right

RALDH retinaldehyde dehydrogenase

RNA ribonucleic acid

ROC receiver operating characteristic

RT-PCR reverse transcriptase polymerase chain reaction

RV right ventricle

RXRα retinoic acid receptor α

S slope

sca-1 stem cell antigen-1

SCN5a voltage-gated sodium channel, α−subunit

SD standard deviation

SDF-1α stromal cell-derived factor-1α SEM scanning electron microscopy SEM standard error of the mean

Sens sensitivity

SERCA2a sarcoplasmic or endoplasmic reticulum Ca2+ ATP-ase

SHF second heart field

SHH sonic hedgehog

SMC smooth muscle cell

sMHC sarcomeric myosin heavy chain smMHC smooth muscle myosin heavy chain

SP side population

Spec specificity

SPIO superparamagnetic iron-oxide

Sprsw slope of preload recruitable stroke work relation

SV stroke volume

SV sinus venosus

SW stroke work

Tau relaxation time constant

TE echo time

TGFβ transforming growth factor β TIMP tissue-inhibitor of metalloproteinase

TR repetition time

TSP trombospondin

TUNEL terminal deoxynucleotidyl transferase biotin dUTP nick-end labeling

v vein

V ventricle

VCAM vascular cell adhesion molecule

205

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VP venous pole

VS ventricular septum

vWF von Willebrand factor

WT1 Wilms’ Tumor 1 suppressor protein