From cardiogenesis to cardiac regeneration : focus on epicardium-derived cells
Winter, E.M.
Citation
Winter, E. M. (2009, October 15). From cardiogenesis to cardiac regeneration : focus on epicardium-derived cells. Retrieved from https://hdl.handle.net/1887/14054
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Fro m
Cardiogenesis to Cardiac
Regeneratio n Focus on
Epicardium- Derived Cells
Liesbeth Winter
Colophon
From Cardiogenesis to Cardiac Regeneration.
Focus on Epicardium-Derived Cells Elizabeth Martha Winter
Thesis Leiden University Medical Center
©2009 Elizabeth M. Winter, Leiden, the Netherlands. All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without written permission of the author.
Cover studio Leclercq, Rotterdam Layout studio Leclercq, Rotterdam Printed by NPN Drukkers
ISBN 978-90-9024546-1
From Cardiogenesis to Cardiac Regeneration Focus on Epicardium-Derived Cells
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. Mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 15 oktober 2009
klokke 16.15 uur
door
Elizabeth Martha Winter geboren te Haarlem
in 1979
Promotiecommissie
Promotores Prof. Dr. A.C. Gittenberger-de Groot Prof. Dr. R.E. Poelmann
Co-promotores Dr. M.J. Goumans
Dr. D.E. Atsma
Overige leden Prof. Dr. J.A. Romijn
Dr. R. Passier
Prof. Dr. R.A. Bank (Rijksuniversiteit Groningen)
The work presented in this thesis was carried out at the Department of Anatomy and Embryology of the Leiden University Medical Center and was supported by a grant from the Interuniversity Cardiology Institute of the Netherlands (05.303).
Financial support by the Netherlands Heart Foundation and the Interuniversity Cardiology Institute of the Netherlands for the publication of this thesis is gratefully acknowledged.
The realization of this thesis was also financially supported by the Matty Brand Stichting, J.E.
Jurriaanse Stichting, Boehringer Ingelheim, Astellas Pharma and Astra Zeneca.
Maximus in Minimis
Chapter 1
General Introduction
Chapter 2
Epicardium-derived cells in cardiogenesis and cardiac regeneration.
Cellular and Molecular Life Sciences, CMLS. 2007; 64(6): 692-703
Chapter 3
Preservation of left ventricular function and attenuation of remodeling after transplantation of human epicardium-derived cells into the infarcted mouse heart.
Circulation. 2007; 116(8): 917-927
Chapter 4
The potential of epicardium in the first week after myocardial infarction.
Submitted for publication
Chapter 5
A new direction for cardiac regeneration therapy: application of synergistically acting epicardium-derived cells and cardiomyocyte progenitor cells.
Circulation: Heart Failure. 2009; in press
Chapter 6
Mesenchymal stem cells from ischemic heart disease patients improve left ventricular function after acute myocardial infarction.
American Journal of Physiology. 2007; 293(4): H2438-H2447.
Contents
9-22
25-42
43-70
71-94
95-130
133-152
Part 1
Epicardium-derived cells and their potential in the infarcted adult heart.
Part 2
Mesenchymal stem cells as source for
cardiac regeneration
Chapter 7
Left ventricular function in the post-infarct failing mouse heart by magnetic resonance imaging and conductance catheter: a comparative analysis.
Acta Physiologica. 2008; 194(2): 111-122
Chapter 8
Cell tracking using iron-oxide fails to distinguish dead from living transplanted cells in the infarcted heart.
Magnetic Resonance in Medicine. 2009; in press
Chapter 9 General Discussion
Abbreviations Summary Samenvatting Publications Curriculum Vitae Dankwoord 155-172
173-182
183-199
200 206 210 214 220 222
