• No results found

Clinicopathologic and genetic features of primary cutaneous B-cell lymphoma

N/A
N/A
Protected

Academic year: 2021

Share "Clinicopathologic and genetic features of primary cutaneous B-cell lymphoma"

Copied!
16
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

Clinicopathologic and genetic features of primary cutaneous B-cell

lymphoma

Hoefnagel, J.J.

Citation

Hoefnagel, J. J. (2007, January 11). Clinicopathologic and genetic features of primary

cutaneous B-cell lymphoma. Retrieved from https://hdl.handle.net/1887/8769

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the

Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/8769

Note: To cite this publication please use the final published version (if applicable).

(2)



(3)



&XUULFXOXPYLWDH

(4)



(5)



-XOLHWWH+RHIQDJHOZHUGJHERUHQRSMXQLWH/HLGHUGRUS=LMJURHLGHRSLQ:DUPRQGHQGRRUOLHSKDDU

PLGGHOEDUHVFKRRODDQKHW5LMQODQGV/\FHXPWH2HJVWJHHVW1DKHWEHKDOHQYDQKHWHLQGH[DPHQ9:2LQ

EHJRQ]LMLQGDW]HOIGHMDDUKDDUVWXGLHJHQHHVNXQGHDDQGH5LMNVXQLYHUVLWHLW/HLGHQ

7LMGHQVGHVWXGLHYHUULFKWWH]LMRQGHU]RHNQDDUULVLFRIDFWRUHQYRRUEDVDDOFHOFDUFLQRPHQHQQDDUELMZHUNLQJHQ

YDQ PLQRF\FOLQH HQ IXPDDU]XXUWKHUDSLH 'U -1 %RXZHV %DYLQFN 'U 07%DVWLDHQV 'U +% 7KLR

$IGHOLQJ'HUPDWRORJLH/HLGV8QLYHUVLWDLU0HGLVFK&HQWUXP 9RRUDIJDDQGDDQKDDUFRDVVLVWHQWVFKDSSHQ

GHHG ]LM JHGXUHQGH HHQ SHULRGH RQGHU]RHN QDDU H[SUHVVLH YDQ FRVWLPXODWRLUH HQ DGKHVLHPROHFXOHQ ELM

DFXWH P\HORLGH OHXNHPLH 'U 5( %URXZHU SURI GU -+) )DONHQEXUJ $IGHOLQJ +HPDWRORJLH /HLGV

8QLYHUVLWDLU0HGLVFK&HQWUXP 'DDUQDDVWZDV]LMGHVWLMGVZHUN]DDPRSGHUHGDFWLH1LHXZVEHULFKWHQYDQ

KHW1HGHUODQGV7LMGVFKULIWYRRU*HQHHVNXQGH

1D KHW GRRUORSHQ YDQ GH FRDVVLVWHQWVFKDSSHQ ZHUG LQ  KHW DUWVH[DPHQ FXP ODXGH  EHKDDOG ,Q

QRYHPEHUZHUG]LMDDQJHVWHOGDOV$*,.2 DUWVJHQHHVNXQGLJHLQNOLQLVFKRQGHU]RHN RSGH$IGHOLQJ

'HUPDWRORJLHYDQKHW/HLGV8QLYHUVLWDLU0HGLVFK&HQWUXPHQZHUGDDQJHYDQJHQPHWSURPRWLHRQGHU]RHN

QDDUSULPDLUFXWDQH%FHOO\PIRPHQRQGHUEHJHOHLGLQJYDQSURIGU5:LOOHP]H6LQGVMDQXDULLV]LM

ZHUN]DDPDOVDUWVDVVLVWHQWLQRSOHLGLQJWRWGHUPDWRORRJ

(6)



(7)



3XEOLFDWLHV

(8)



(9)



%LMZHUNLQJHQYDQPLQRF\FOLQHLQGHEHKDQGHOLQJYDQDFQHYXOJDULV

--+RHIQDJHO+0DWWLH5/YDQ/HHXZHQ07%DVWLDHQV

Nederlands Tijdschrift voor Geneeskunde

'LIIHUHQFHVLQDJHVLWHGLVWULEXWLRQDQGVH[EHWZHHQQRGXODUDQGVXSHU¿FLDOEDVDOFHOOFDUFLQRPDLQGLFDWH

GLIIHUHQWW\SHVRIWXPRUV

07%DVWLDHQV--+RHIQDJHO-$%UXLMQ5*:HVWHQGRUS%-9HUPHHU-1%RXZHV%DYLQFN Journal of Investigative Dermatology

([SUHVVLRQRIFRVWLPXODWRU\DQGDGKHVLRQPROHFXOHVDQGFKHPRNLQHRUDSRSWRVLVUHFHSWRUVRQDFXWH

P\HORLGOHXNDHPLDKLJK&'DQG&'DH[SUHVVLRQFRUUHODWHVZLWKSRRUSURJQRVLV

5(%URXZHU--+RHIQDJHO%%RUJHUYDQGHU%XUJ,-HGHPD.+=ZLQGHUPDQ,&6WDUUHQEXUJ+&

.OXLQ1HOHPDQV50%DUJH5:LOOHP]H-+)DONHQEXUJ Britisch Journal of Haematology

/RQJWHUPVDIHW\DVSHFWVRIV\VWHPLFWKHUDS\ZLWKIXPDULFDFLGHVWHUVLQVHYHUHSVRULDVLV

--+RHIQDJHO+%7KLR5:LOOHP]H-1%RXZHV%DYLQFN Britisch Journal of Dermatology

%FO%FODQG&'H[SUHVVLRQLQFXWDQHRXV%FHOOO\PSKRPDIXUWKHUVXSSRUWIRUDIROOLFOHFHQWUHFHOO

RULJLQDQGGLIIHUHQWLDOGLDJQRVWLFVLJQL¿FDQFH

--+RHIQDJHO0+9HUPHHU30-DQVHQ*-)OHXUHQ&-/00HLMHU5:LOOHP]H Britisch Journal of Dermatology

6RODUOHQWLJLQHVDUHVWURQJO\UHODWHGWRVXQH[SRVXUHLQFRQWUDVWWRHSKHOLGHV

07%DVWLDHQV--+RHIQDJHO5*:HVWHQGRUS%-9HUPHHU-1%RXZHV%DYLQFN Pigment Cell Research

'LVWLQFWW\SHVRISULPDU\FXWDQHRXV%FHOOO\PSKRPDLGHQWL¿HGE\JHQHH[SUHVVLRQSUR¿OLQJ

--+RHIQDJHO5'LMNPDQ.%DVVR30-DQVHQ&+DOOHUPDQQ5:LOOHP]H&37HQVHQ0+9HUPHHU Blood

),6+DQDO\VLVRI0$/7O\PSKRPDVSHFL¿FWUDQVORFDWLRQVDQGDQHXSORLG\LQSULPDU\FXWDQHRXVPDUJLQDO

]RQHO\PSKRPD

0,6FKUHXGHU--+RHIQDJHO30-DQVHQ-+YDQ.ULHNHQ5:LOOHP]H.0+HEHGD Journal of Pathology

.OLQLVFKHHQWKHUDSHXWLVFKHDVSHFWHQYDQKHWSULPDLUFXWDQHPDUJLQDOH]RQH%FHOO\PIRRP --+RHIQDJHO0+9HUPHHU5:LOOHP]H

Nederlands Tijdschrift voor Dermatologie en Venereologie

(10)



2QGHU]RHNQDDUGLDJQRVWLVFKHHQSURJQRVWLVFKHSDUDPHWHUVELMSULPDLUFXWDQHJURRWFHOOLJH%FHOO

lymfomen

0+9HUPHHU--+RHIQDJHO5'LMNPDQ&37HQVHQ5:LOOHP]H

Nederlands Tijdschrift voor Dermatologie en Venereologie

3ULPDU\FXWDQHRXVPDUJLQDO]RQH%FHOOO\PSKRPD&OLQLFDODQGWKHUDSHXWLFIHDWXUHVLQFDVHV

--+RHIQDJHO0+9HUPHHU30-DQVHQ)+HXOH3&YDQ9RRUVW9DGHU&-6DQGHUV0-*HUULWVHQ0/

*HHUWV&-/00HLMHU(01RRUGLMN5:LOOHP]H Archives of Dermatology

$UUD\EDVHGFRPSDUDWLYHJHQRPLFK\EULGL]DWLRQDQDO\VLVUHYHDOVUHFXUUHQWFKURPRVRPDODOWHUDWLRQVDQG

SURJQRVWLFSDUDPHWHUVLQSULPDU\FXWDQHRXVODUJH%FHOOO\PSKRPD

5'LMNPDQ&37HQVHQ(6-RUGDQRYD-.QLMQHQEXUJ--+RHIQDJHO$$0XOGHU&5RVHQEHUJ$.5DDS

5:LOOHP]H.6]XKDL0+9HUPHHU

Journal of Clinical Oncology

([SUHVVLRQRI%FHOOWUDQVFULSWLRQIDFWRUVLQSULPDU\FXWDQHRXV%FHOOO\PSKRPD

--+RHIQDJHO0060XOGHU('UHHI30-DQVHQ673DOV&-/00HLMHU5:LOOHP]H0+9HUPHHU Modern Pathology

$QHWRGHUPDLQSULPDU\FXWDQHRXVPDUJLQDO]RQH%FHOOO\PSKRPD 0+9HUPHHU--+RHIQDJHO30-DQVHQ5:LOOHP]H

LQCutaneous lymphomas: Unusual cases 2*%XUJ:.HPSI HGV 6WHLQNRSII9HUODJ'DUPVWDGW



5HFODVVL¿FDWLRQRISULPDU\FXWDQHRXV%FHOOO\PSKRPDVDFFRUGLQJWRWKHQHZ:+2(257&

FODVVL¿FDWLRQIRUFXWDQHRXVO\PSKRPDVFOLQLFRSDWKRORJLFFRUUHODWLRQVDQGSURJQRVWLFIDFWRUV

1-6HQII--+RHIQDJHO30-DQVHQ0+9HUPHHU-YDQ%DDUOHQ:$%ORN[05&DQQLQJDYDQ'LMN0/

*HHUWV.0+HEHGD30.OXLQ.+/DP&-/00HLMHU

5:LOOHP]H submitted

(11)



Nawoord

(12)



(13)



'HDIJHORSHQMDUHQKHELNPHWYHHOSOH]LHUJHZHUNWDDQKHWRQGHU]RHNEHVFKUHYHQLQGLWSURHIVFKULIW,N

EHQLHGHUHHQGLHKLHUELMEHWURNNHQLVJHZHHVW]HHUGDQNEDDUYRRU]LMQRIKDDULQVSDQQLQJHQ'HYROJHQGH

SHUVRQHQZLOLNJUDDJLQKHWELM]RQGHUEHGDQNHQ

Leden van de Nederlandse Werkgroep Cutane Lymfomen.7LMGHQVGHOHHU]DPHHQJH]HOOLJHELMHHQNRPVWHQ

LQ 8WUHFKW HQ ODWHU LQ /HLGHQ YDQ GHUPDWRORRJ SDWKRORRJ HQ UDGLRWKHUDSHXWRQFRORRJ ZRUGW QDDVW KHW

]RUJGUDJHQYRRURSWLPDOHSDWLsQWHQ]RUJGHEDVLVJHOHJGYRRUKHWXLWYRHUHQYDQZHWHQVFKDSSHOLMNHVWXGLHV

RSJRHGJHGH¿QLHHUGHSDWLsQWHQJURHSHQ,NZLODOOHOHGHQJUDDJEHGDQNHQYRRUKXQEHWURNNHQKHLGKLHUELM

Remco Dijkman, Kees Tensen, Aat Mulder en Wim Zoutman van het Laboratorium Huidziekten. =HHU

EHGDQNWYRRUDOMXOOLHKXOSELMKHWXLWYRHUHQYDQGHH[SHULPHQWHQHQGDDUQDDVWGHJRHGHKHULQQHULQJHQGLH

LNEHZDDUDDQGHJH]HOOLJKHLGRSFRQJUHVVHQLQ1DSHOV1HZ<RUN%HUOLMQHQQLHWWHYHUJHWHQGHMDDUOLMNVH

ELMHHQNRPVWLQ/XQWHUHQ

Enno Dreef en andere betrokken medewerkers van de Afdeling Pathologie. %HVWH (QQR KDUWHOLMN GDQN

YRRUGHLPPXQRKLVWRFKHPLVFKHNOHXULQJHQYDQGHJURWHDDQWDOOHQFXWDQH%FHOO\PIRRPFRXSHVZDDUGRRU

KRRIGVWXNHQJHUHDOLVHHUGNRQGHQZRUGHQ

Konnie Hebeda en Max Schreuder. +DUWHOLMNGDQNYRRUGHSUHWWLJHVDPHQZHUNLQJ.RQQLHGDQNMHZHOYRRU

GHYHOHOHHU]DPHPRPHQWHQLQGHWLMGGDWMHELMRQVWHJDVWZDV

Steven Pals en Marijn Mulder.=HHUEHGDQNWYRRUGHSOH]LHULJHVDPHQZHUNLQJELMGHWRWVWDQGNRPLQJYDQ

KRRIGVWXNYDQGLWSURHIVFKULIW

Paul Douw van der Krap'DQNYRRUMHKXOSELMKHWPDNHQYDQGHPRRLH¿JXUHQYRRUPLMQDUWLNHOHQ1RRLW

JHZHWHQGDWHU]RYHHOPRJHOLMNLVPHWGLJLWDOHIRWR¶V

Carel Staats, Liesbeth van der Raaij en Remco Hermans'H]RUJYXOGLJHRSVODJHQKHWWUDQVSRUWYDQGH

O\PIRRPELRSWHQ]LMQYDQZH]HQOLMNEHODQJYRRUKHWO\PIRRPRQGHU]RHN'DQNKLHUYRRU

Alle arts-assistenten van de poli HuidziektenZLOLNKHHOKDUWHOLMNGDQNHQYRRUKXQFROOHJLDOLWHLWHQQDWXXUOLMN

YRRUDOOHJH]HOOLJHPRPHQWHQELQQHQHQEXLWHQKHW]LHNHQKXLVSoeLNEHZDDUYHHOJRHGHKHULQQHULQJHQDDQ

GH$*,.2WLMGLQKHW³KRN]RQGHUUDPHQ´ZDDUYDQZHKHUKDDOGHOLMNGHJHOXLGVGLFKWKHLGKHEEHQPRHWHQ

WHVWHQDOVKHWVRPVHHQVWHJH]HOOLJGUHLJGHWHZRUGHQNancyLNEHQEOLMGDWMLMKHWRQGHU]RHNQDDUFXWDQH

%FHOO\PIRPHQYRRUW]HW,NNLMNXLWQDDUMRXZSURHIVFKULIW

'HVWDÀHGHQYDQGHSROL+XLG]LHNWHQZLOLNJUDDJEHGDQNHQYRRUGHJHWRRQGHEHODQJVWHOOLQJHQGHUXLPWH

GLHPLMJHERGHQLVRPGHODDWVWHIDVHYDQPLMQSURPRWLHWHYROWRRLHQ

9HUGHUZLOLNDOOHmedewerkers van de patiëntenadministratie, de secretaresses en de verpleegkundigen van de poli HuidziektenEHGDQNHQYRRUKXQKXOSVWHXQHQLQWHUHVVHLQPLMQRQGHU]RHN

/LHYHYULHQGLQQHQ, Arianne, Barbara, Dorine, Fleur, Janneke, Maartje, Titia en ValerieZDWKHELNKHW

JHWURIIHQPHWMXOOLH+HHOYHHOGDQNYRRUDOOHVXSSRUWZLM]HUDDGHQOXLVWHUHQGHRUHQGHDIJHORSHQMDUHQ

De paranimfen./LHYHLieke ZDWHHQJHOXNGDW ZLMLQKHW]HOIGHFRJURHSMHWHUHFKWNZDPHQ,NEHQKHHOEOLM

PHWMRXZYULHQGVFKDSHQKHWIHLWGDWMHPLMQSDUDQLPIZLOGH]LMQ

/LHYHLeontienKRHYHHONLORPHWHUVKHEEHQZLMDOZHOQLHWVDPHQKDUGJHORSHQ"2QGHUWXVVHQZHUGKHWZHO

HQZHHYDQKHW$*,.2EHVWDDQDOWLMGXLWJHEUHLGHQPHWYHHOKXPRUEHVSURNHQ,NKRRSGDWZHGHNRPHQGH

MDUHQVDPHQQRJYHHOURQGMHV]XOOHQORSHQ

/LHYHMaarten Jan]R]LHMHPDDUGDWMRXZRXGHFRPSXWHU]¶QQXWPHHUGDQRSJHEUDFKWKHHIW,NYLQGKHW

KHHO¿MQGDWMLMVDPHQPHW(OHRQRUHDDQZH]LJEHQWRSMDQXDUL

Mijn ouders. /LHYH SDSD HQ PDPD JHGXUHQGH GH DIJHORSHQ MDUHQ KHEEHQ MXOOLH DOWLMG RS DOOH PRJHOLMNH

PDQLHUHQYRRUPLMNODDUJHVWDDQ+HHOYHHOGDQNYRRUMXOOLHVWHXQHQEHODQJVWHOOLQJ

/LHYHRemcoGDQNMHZHOYRRUDOKHWJHOXNGDWMHPHJHHIW

(14)



(15)



(16)



Referenties

GERELATEERDE DOCUMENTEN

3,4,6 In the World Health Organization (WHO) classification these PCFCCLs are not recognized as a distinct entity, but—according to traditional morphological criteria—are

Relapse-free survival (RFS) in 27 patients with primary cutaneous marginal zone B-cell lymphoma (PCMZL) who presented with multifocal skin lesions (5-year RFS rate, 39%) and in

Hierarchical clustering analysis of primary cutaneous follicle center cell lymphoma (PCFCCL) and primary cutaneous large B-cell lymphoma of the leg (PCLBCL-leg) was performed based

High-resolution analysis of chromosome 2 demonstrating (A) the fre- quency of gains and losses in a typical primary cutaneous follicle center lymphoma patient, (B) the amplification

The tumor cells expressed early B-cell transcription factors Pax-5 and PU.1, germinal center marker Bcl-6, transcrip- tion factors Oct2 and BOB.1, but not the plasma cell and

1.2.. Main genetic aberrations of primary cutaneous follicle center lymphoma... Conclusions and perspectives. 7KH VWXGLHV GHVFULEHG LQ WKLV WKHVLV KDYH UHVXOWHG

YHQ LQ KRRIGVWXN  ZHUG ELM  YDQ GH SDWLsQWHQ PHW. HHQ3&amp;0=/HHQDVVRFLDWLHPHWHHQBorrelia burgdorferi LQIHFWLH JHYRQGHQ 5HFHQW ]LMQ ELM

Gezien het indolente klinische beloop en de uitstekende prognose van het primair cutane marginale zone B-cel lymfoom, dient bij de behandeling een goede balans te worden gezocht