• No results found

VU Research Portal

N/A
N/A
Protected

Academic year: 2021

Share "VU Research Portal"

Copied!
2
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

VU Research Portal

Macrophage-targeted PET imaging of Rheumatoid Arthritis

Gent, Y.

2015

document version

Publisher's PDF, also known as Version of record

Link to publication in VU Research Portal

citation for published version (APA)

Gent, Y. (2015). Macrophage-targeted PET imaging of Rheumatoid Arthritis: opportunities for early diagnostics

and therapy monitoring.

General rights

Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. • Users may download and print one copy of any publication from the public portal for the purpose of private study or research. • You may not further distribute the material or use it for any profit-making activity or commercial gain

• You may freely distribute the URL identifying the publication in the public portal ?

Take down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

E-mail address:

vuresearchportal.ub@vu.nl

(2)

CONTENTS

Chapter 1 Introduction 7

PART I Visualization of subclinical synovitis in rheumatoid arthritis

Chapter 2 Present role of positron emission tomography in diagnosis 20 and monitoring of peripheral inflammatory arthritis:

a systematic review.

Arthritis Care Res 2014; 66:120-130

Chapter 3 Macrophage positron emission tomography imaging as a 46 biomarker for preclinical rheumatoid arthritis:

findings of a prospective pilot study.

Arthritis Rheum 2012;64:62-66

Chapter 4 Three-year clinical outcome following baseline magnetic 58 resonance imaging in anti-citrullinated protein antibody-positive

arthralgia patients: an exploratory study.

Arthritis Rheumatol 2014;66:2909-10

Chapter 5 Detection of subclinical synovitis in macrophage targeting and 71 positron emission tomography in patients with rheumatoid arthritis without clinical arthritis.

J Rheumatol 2014; 41:2145-52

Chapter 6 Subclinical synovitis detected by macrophage PET, but not MRI, is 89 related to short-term flare of clinical disease activity in

early RA patients

Submitted for publication

Part II Novel macrophage-targeting PET tracers

Chapter 7 Promising potential of new generation translocator protein tracers 103 providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis

Arthritis Res Ther 2014;16:R70

Chapter 8 Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate 126

for macrophage targeting in a rat model of arthritis

Arthritis Res Ther 2013,15:R37

Chapter 9 Discussion and future perspectives 150

Summary 157

Samenvatting 160

List of publications 164

Dankwoord 165

Referenties

GERELATEERDE DOCUMENTEN

Currently, rheumatoid factor (RF) and anti-cyclic citrullinated protein antibodies (ACPA) are the most specific for RA, respectively 80% and 95% 31. Both autoantibodies can

In 2001, based on the premise that autoantibodies derived from B-cell-derived antibody-secreting cells were closely associated with disease pathogenesis, the first study was

Importantly, positivity for circulating ACPA-IgM, in combination with a high infiltration of CD79a+ B-cells in the synovium, but not of CD138+ plasma cells, was a predictor

The present study demonstrated that a low disease activity state following ri- tuximab was associated with reduced infiltration of CD79a+ CD20- plasma cells in synovium and

To investigate the distribution of lymphocytes, notably B-cells, in peripheral blood (PB) and bone marrow (BM) of RA patients as compared to healthy con- trols, and to analyze

The present study compared the efficacy and safety of two B-cell depleting strategies in refractory RA patients, namely fixed retreatment (FR) versus on- demand retreatment (ODR)

The effective competition of rituximab against cell-bound anti-CD20 antibody and the failure of increasing concentrations of 2H7 to dislodge rituximab after binding to

A recent report on the early depleting effects of rituximab in the synovial tissue of patients with rheumatoid arthritis (RA) showed that the tissue depletion of CD22+ cells