Targeting the humoral immune system of patients with rheumatoid arthritis
Teng, Y.K.O.
Citation
Teng, Y. K. O. (2008, October 7). Targeting the humoral immune system of patients with rheumatoid arthritis. Retrieved from https://hdl.handle.net/1887/13404
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13404
Note: To cite this publication please use the final published version (if applicable).
T ARGETING THE
H UMORAL I MMUNE S YSTEM OF P ATIENTS WITH
R HEUMATOID A RTHRITIS
Cover illustration: Datawyse Maastricht Printing: Datawyse / Universitaire Pers Maastricht
ISBN 978 90 5291 102 1
© Copyright Y.K.O. Teng, Leiden 2008
All rights reserved. No part of this thesis may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording or any information appropriate, without the prior written permission of the publishers of the publications.
T ARGETING THE
H UMORAL I MMUNE S YSTEM OF P ATIENTS WITH
R HEUMATOID A RTHRITIS
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 7 oktober 2008 klokke 13.45 uur
door
Yoe Kie Onno Teng geboren te Rotterdam
in 1981
Promotiecommissie
Promotores: Prof. Dr. T.J. Huizinga
Prof. Dr. J.M. van Laar (Newcastle University) Co-promotor: Dr. R.E.M. Toes
Referent: Dr. D. Baeten (Universiteit Amsterdam)
Leden: Prof. Dr. T. Dörner (Humboldt University, Berlijn) Dr. M.J. van Tol
Prof. Dr. J.H. Falkenburg Prof. Dr. F. Koning
The studies described in this thesis were financially supported by an AGIKO grant from the Netherlands Organisation for Science (NWO).
The printing of this thesis was also financially support by:
Abbott, Bristol-Myers Squibb, MSD, Pfizer, Reumafonds, Roche, Teva Pharma NL, Wyeth
“Take into account that great love and great achievements involve great risk”
Dalai Lama
voor Anouk, mijn ouders en broer
Contents
Chapter 1 General introduction 9
Chapter 2 Targeted therapies in rheumatoid arthritis: focus 21
on rituximab
Chapter 3 Immunohistochemical analysis as a means to predict 41 responsiveness to rituximab treatment
Chapter 4 Residual inflammation after rituximab treatment is 65 associated with sustained synovial plasma cell
infiltration and enhanced B-cell repopulation
Chapter 5 Enhanced differentation of B-cells towards immuno- 81 globulin-secreting cells in rheumatoid arthritis
Chapter 6 Rituximab fixed retreatment versus on-demand retreatment in refractory rheumatoid arthritis.
Chapter 7 CD20 epitope masking by rituximab
Chapter 8 CD22 is not expressed merely on B-cells 119
Chapter 9 Sustained secretion of immunoglobulin by long-lived 123 human tonsil plasma cells
Chapter 10 Long-term followup of health status in patients with 147 severe rheumatoid arthritis after high-dose chemo-
therapy followed by autologous hematopoietic stem cell transplantation
95
115
Chapter 11 Differential responsiveness to immunoablative therapy 159 in refractory rheumatoid arthritis is associated with
level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study
Chapter 12 Anticyclic citrullinated peptide antibodies: the footprint 179 of autoreactive plasma cells in synovium?
Summary, conclusions and future perspectives 201 Samenvatting, conclusies en toekomstperspectieven 21
Dankwoord 219
Curriculum vitae 221
List of publications 222
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