University of Groningen
Exploring the Staphylococcus aureus cell wall for invariant immunodominant targets
Mora Hernández, Yaremit
DOI:
10.33612/diss.147005930
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Mora Hernández, Y. (2020). Exploring the Staphylococcus aureus cell wall for invariant immunodominant targets. University of Groningen. https://doi.org/10.33612/diss.147005930
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Exploring the Staphylococcus aureus cell wall
for invariant immunodominant targets
Contact: Questions and comments can be directed to yare.morita@gmail.com Exploring the Staphylococcus aureus cell wall for invariant immunodominant targets Dissertation of the University of Groningen
ISBN: 978-94-6421-124-5
Cover photo: “Vacas de tesis” oil painting by Emmanuel Chontal Jácome Printing: Ipskamp Printing, Enschede, the Netherlands
Copyright © Yaremit Mora-Hernández, 2020. All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author.
Exploring the Staphylococcus aureus cell wall
for invariant immunodominant targets
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with the decision by the College of Deans.
This thesis will be defended in public on
Monday 16 November 2020 at 12:45 hours
by
Yaremit Mora-Hernández born on 14th February 1989
Supervisor Prof. J.M. van Dijl
Co-supervisor Dr. G. Buist
Assessment committee Prof. S. Hammerschmidt Prof. H.C. van der Mei Prof. P. Heeringa
Paranymphs
Elías Vera Murguía, MSc.
Gabriela Bravo Ruiseco Sánchez, MSc.
Marina López Álvarez, MSc.
The PhD research described in this thesis was performed in the laboratory of Molecular Bacteriology, Department of Medical Microbiology, of the University of Groningen and the University Medical Center Groningen, the Netherlands.
This research was financially supported by the National Council of Science and Technology (CONACyT, México), and the Graduate School of Medical Sciences of the University of Groningen.
Printing of this thesis was supported by the Graduate School of Medical Sciences of the University of Groningen.
Table of Contents
CHAPTER 1. General Introduction and Scope ...
1
Immune defenses of the mammary gland ... 3
Pathology of mastitis ... 5
Virulence factors of S. aureus ... 9
S. aureus antigens tested as vaccine targets ...12
Scope of the thesis ... 14
CHAPTER 2. Molecular typing and antibiotic resistance profiling of mastitis-related Staphylococcus aureus isolates from Mexican cow ... 25
CHAPTER 3. Profiling the cell wall proteome of Mexican Staphylococcus aureus isolates associated with bovine mastitis ... 51
CHAPTER 4. Differential Binding of Human and Murine IgGs to Catalytic and Cell Wall Binding Domains of Staphylococcus aureus Peptidoglycan Hydrolases ... 91
CHAPTER 5. General summarizing discussion ... 123
CHAPTER 6. Nederlandse samenvatting ... 139
