University of Groningen
Air pollution exposure of lung models Cattani Pinto Cavalieri, Isabella
DOI:
10.33612/diss.172080794
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Cattani Pinto Cavalieri, I. (2021). Air pollution exposure of lung models: focus on inflammation, oxidative stress and cyclic AMP signaling. University of Groningen. https://doi.org/10.33612/diss.172080794
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
1. Diesel exhaust particles (DEP) may promote changes in the cellular ability to produce cAMP through the altered expression of Gs-protein-coupled receptors and members of the AC superfamily (this thesis).
2. Dimethyl fumarate may be a potential drug to diminish DEP-induced lung injury, inflammation, and oxidative and nitrosative stress (this thesis).
3. AKAP1 acts as a mitochondrial scaffold protein which is associated with mitochondrial cAMP compartmentalization and function. The gene expression of AKAP1 is upregulated by DEP exposure. Therefore, DEP exposure may play a role in the alterations of mitochondrial function through the changes of AKAP1 and could potentially contribute to lung dysfunction.
4. DEP exposure impaired mitochondrial function seen by modifications in mitochondrial morphology and bioenergetics, including mitochondrial respiration and glycolytic reserve (this thesis).
5. Acute exposure of mice to diesel-biodiesel particulate matter (DBPM) showed the induction of inflammation and promoted oxidative damage (this thesis).
6. “Science is not only a disciple of reason but also one of romance and passion.” Stephen Hawking
7. "When you reach the end of your rope, tie a knot in it and hang on." Franklin D. Roosevelt
8. "The future belongs to those who believe in the beauty of their dreams." Eleanor Roosevelt
