University of Groningen
Applications of biophysical methods in small-molecule modulators targeting protein function Wang, Wenjia
DOI:
10.33612/diss.156123664
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Wang, W. (2021). Applications of biophysical methods in small-molecule modulators targeting protein function. University of Groningen. https://doi.org/10.33612/diss.156123664
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Applications of biophysical
methods in small-molecule
modulators targeting protein
function
The research presented in this PhD thesis was performed at the Department of Drug Design, University of Groningen, the Netherlands.
Applications of biophysical
methods in small-molecule
modulators targeting protein
function
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on
Friday 12 February 2021 at 12.45 hours
by
Wenjia Wang
born on 2 June 1989 in Heilongjiang, China
Supervisors
Prof. A.S.S. Dömling Prof. M.R. GrovesAssessment Committee
Prof. J.M. van DijlProf. T.A. Holak Prof. D.J. Slotboom
Contents
1 Introduction 2
2 Artificial Macrocycles as IL17A/IL17RA Antagonists 11 3 Ligand-Directed Diazotransfer Chemistry Reveals Structural Metal-Dependent
Features of Bovine Carbonic Anhydrase II 23 4 The Crystal Structure of the Plasmodium falciparum PdxK Provides an
Experi-mental Model for Pro-Drug Activation 59 5 Amino acid Derivatives as a Scaffold for the Discovery of IL17A binders 80 6 Structure-Activity Based IL17A/IL17RA Small-Molecule Antagonists Discovery 99 7 The human milk oligosaccharides 3-FL, LNnT, and LDFT attenuate TNF-α
in-duced inflammation in fetal intestinal epithelial cells through shedding or inter-acting with TNF receptor 1 114
8 Summary 138
A Nederlandse Samenvatting 141 B About the author 144
C Publications 145
D Acknowledgement 146
