University of Groningen
Understanding compartmentalized cAMP signaling for potential therapeutic approaches in cardiac disease
Musheshe, Nshunge
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Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Musheshe, N. (2018). Understanding compartmentalized cAMP signaling for potential therapeutic
approaches in cardiac disease: Insights into the molecular mechanisms of the cAMP-mediated regulation of the cardiac phospholemman-Na+/K+ ATPase complex. University of Groningen.
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Propositions
Nshunge MushesheUnderstanding compartmentalized cAMP signaling for potential therapeutic
approaches in cardiac disease
1) Sophisticated Fluorescence Resonance Energy Transfer (FRET) techniques are the future to developing targeted therapy for cardiac diseases– discussed in this thesis
2) PDE8 and PDE2 are novel drug targets for cardiac disease – discussed in this thesis 3) Phosphatases play a crucial role in compartmentalizing Protein Kinase A signals in
Excitation Contraction coupling – discussed in this thesis
4) Understanding the effect on cellular signaling when targeted FRET sensors are expressed in cells is crucial for accurate interpretation of signaling results – discussed in thesis 5) The success of pluripotent stem cell research as a tool for translational medicine will
depend on high quality culture conditions – Evans and Kaufman, Nature 1981 6) To achieve global health – holistic reform in pharma and biotechnology is necessary 7) No matter how you get there or where you end up – human beings have the miraculous
