Cover Page
The handle http://hdl.handle.net/1887/66035 holds various files of this Leiden University
dissertation.
Author: Couperus, L.E.
Title: Diagnosis and treatment of right ventricular overload in high risk populations
Issue Date: 2018-09-26
Diagnosis and Treatment of
Right Ventricular Overload
in High Risk Populations
Lotte Eline Couperus
The studies described in this thesis were performed at the Heart Lung Center of the Leiden University Medical Center, Leiden, the Netherlands
Cover and lay-out: J. Machielsen en L.E. Couperus Print: Off Page Amsterdam
IBSN: 978-94-6182-901-6
Copyright © L.E. Couperus, Leiden, the Netherlands, 2018
All rights reserved. No part of this book may be reproduced, distributed or transmitted in any form or by any means without prior written permission of the author.
Financial support to the costs associated with publication of this thesis was generally provided by Actelion Pharmaceuticals Nederland BV (Woerden, the Netherlands) and Alrijne Hospital.
Diagnosis and Treatment of
Right Ventricular Overload
in High Risk Populations
Proefschrift
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden
op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker
volgens besluit van het College voor Promoties
te verdedigen op woensdag 26 september 2018
klokke 16.15 uur
door
Lotte Eline Couperus
Geboren te Leiden
in 1987
Promotor:
Prof. dr. M.J. Schalij
Co-promotores:
Dr. S.L.M.A. Beeres
Dr. R.W.C. Scherptong
Leden promotiecommissie:
Prof. dr. B.J.M. Mulder - van der Wall; Academisch Medisch Centrum,
Amsterdam, Nederland
Prof. dr. R.A. de Boer; Universitair Medisch Centrum Groningen, Nederland
Prof. dr. D.E. Atsma
Prof. dr. R.J.M. Klautz
Prof. dr. M.G. Hazekamp
Dr. H.W. Vliegen
Financial support by the Dutch Heart Foundation for the publication of this thesis
is gratefully acknowledged.
Aan mijn ouders
Table of Contents
Chapter 1 General Introduction and Outline of this Thesis 9
Part I - Right Ventricular Overload in Left Sided Heart Disease
Chapter 2 Right Ventricular Dysfunction Affects Survival after Surgical Left Ventricular Restoration
31
Chapter 3 Right Ventricular Dysfunction after Surgical Left Ventricular Restoration;
Prevalence, Risk Factors and Clinical Implications
47
Chapter 4 Pump Speed Optimization in Stable Patients with a Left Ventricular Assist Device
65
Part II - Right Ventricular Overload in Congenital Heart Disease
Chapter 5 Long-Term Outcome after Atrial Correction for Transposition of the Great Arteries Exceeds 50 Years
83
Chapter 6 Tailored Circulatory Intervention in Adults with Pulmonary Hypertension due to Congenital Heart Disease
101
Part III - Right Ventricular Overload in Diseases Associated with Pulmonary Arterial Hypertension
Chapter 7 Electrocardiographic Detection of Pulmonary Hypertension in Patients with Systemic Sclerosis using the Ventricular Gradient
117
Chapter 8 Prognostic Importance of Increased Right Ventricular Afterload in Orthotopic Liver Transplantation Recipients with Endstage Cirrhosis
135
Chapter 9 Summary, Conclusions and Future Perspectives Samenvatting, Conclusies en Toekomstperspectieven
151 161
List of Publications 173
Dankwoord 175
Curriculum Vitae 177
