Citation
Henkens, I. R. (2008, November 20). Non-invasive diagnosis and follow-up of right ventricular overload. Retrieved from https://hdl.handle.net/1887/13265
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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N ON - INVASIVE DIAGNOSIS AND FOLLOW - UP
OF RIGHT VENTRICULAR OVERLOAD
Colophon
The studies described in this thesis were performed at the department of Cardiology,
Leiden University Medical Center, Leiden, the Netherlands, and at the departments of Pulmonology and Physiology of the VU University Medical Center, Amsterdam, the Netherlands.
Cover design
Jurgen Kuivenhoven, industrial designer at Skottkarra, Amsterdam, The Netherlands.
Layout
Annette Heijn, Delft, The Netherlands
Printing
Gildeprint, Enschede, The Netherlands
ISBN 978-90-7138-266-6
© 2008 Ivo R. Henkens, The Hague, The Netherlands.
All rights reserved. No part of this book may be reproduced or transmitted in any form or by any means, without prior written permission of the author.
N ON - INVASIVE DIAGNOSIS AND FOLLOW - UP
OF RIGHT VENTRICULAR OVERLOAD
Ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 20 november 2008 klokke 13:45 uur
door
Ivo Henkens geboren te Leiderdorp
in 1977
Leden Prof. Dr. A. van der Laarse (Leids Universitair Medisch Centrum, Leiden)
Dr. A. Vonk Noordegraaf (VU Medisch Centrum, Amsterdam)
Dr. A. Boonstra (VU Medisch Centrum, Amsterdam) Dr. C.A. Swenne (Leids Universitair Medisch Centrum, Leiden)
Page
Chapter I Introduction 7
Part I Right ventricular volume overload
Chapter II Preoperative determinants of recovery time in adult Fallot
patients after late pulmonary valve replacement 41 Chapter III Predicting outcome of pulmonary valve replacement in adult
tetralogy of Fallot patients 47
Chapter IV Pulmonary valve replacement improves the repolarization in
tetralogy of Fallot 61
Part II Right ventricular pressure overload
Chapter V Early changes in rat hearts with developing pulmonary arterial hypertension can be detected with three-dimensional
electrocardiography 77 Chapter VI Improved ECG detection of presence and severity of right
ventricular pressure load validated with cardiac magnetic
resonance imaging 97
Chapter VII Pulmonary hypertension: the role of the electrocardiogram 119 Chapter VIII Electrocardiographic monitoring of treatment response in
pulmonary arterial hypertension patients 129 Chapter IX Resting heart rate reflects prognosis in patients with
idiopathic pulmonary arterial hypertension 147 Chapter X Summary, conclusions, and future perspectives
Samenvatting, conclusies en toekomstperspectieven 169
Publicatielijst 193
Dankwoord 199
Curriculum vitae 203
