The role of the ubiquitin system in human cytomegalovirus-mediated degradation of MHC class I heavy chains

Since expression of Serpins may facilitate the immune escape of HLA positive tumors, we next analysed the effect of Serpin expression on survival in cases with normal/partial

The fact that we found an abrogation of US11-mediated dislocation, in the presence of proteasome inhibitor only and exclusively in cells lacking Ƣ2m expression may imply that US11

The non-tagged, wild-type MHC class I heavy chains could be precipitated using the exogenously added C-terminus-specific antiserum, but not with the pre-immune serum or the

Unlike US2-mediated dislocation, US11-mediated dislocation of class I heavy chains depends on the small multi-spanning ER membrane protein Derlin-1, which can be found in complex

Ubiquitination is essential for human cytomegalovirus US11-mediated dislocation of MHC class I molecules from the endoplasmic reticulum to the cytosol. van

Peripheral blood cells were stained with HLA-A2.1 tetramers containing the tyrosinase368–376 peptide followed by staining with a panel of lineage antibodies, as described in

Blades and blade fragments seem to have been especially used for longitudinal motions, mainly on plant material (7/12). Flake and flake fragments are used in different motions on

This shape also occurs in the combination artefacts (see below). The shape is the result of intensive use in a repetitive abrasive motion, carried out from different angles. In