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(1)

20/20:

Twenty years after the first catheter

ablation of atrial fibrillation

Towards freedom from procedure related complications and atrial fibrillation recurrence

(2)

Colophon

The Studies in these thesis were conducted at the Department of Cardiology of the Leiden

University Medical Center, Leiden. The Netherlands.

Cover design & layout:

© evelienjagtman.com

Printed by: Ridderprint | www.ridderprint.nl

ISBN:

978-94-6416-038-3

© 2020 Fehmi Keçe, Leiden. The Netherlands.

All rights are reserved. No part of this book may be reproduced or transmitted, in any from

or by any means, without prior permission of the author.

(3)

20/20:

Twenty years after the first catheter

ablation of atrial fibrillation

Towards freedom from procedure related complications and atrial fibrillation recurrence

Proefschrift

Ter verkrijging van

de graad van Doctor aan de Universiteit Leiden

op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker

volgens het besluit van het College voor Promoties

te verdedigen op donderdag 19-11-2020

klokke 10 uur

Door

Fehmi Keçe

Geboren te Amsterdam

(4)

Promotor:

Prof. Dr. K. Zeppenfeld

Co-promotor:

Dr. S.A.I.P. Trines

Leden promotiecommissie:

Prof. dr. H.C.J. Eikenboom

Prof. dr. D. Steven (Universiteit van Keulen)

Dr. A.P. Wijnmaalen

(5)

Freedom, in any case,

is only possible by

constantly struggling for it.

Albert Einstein (1879 – 1955)

Voor Özgür

1

en Arzu

(6)

Chapter 1 General introduction and outline of the thesis

P11

Chapter 2

The impact of advances in atrial fibrillation ablation devices on the incidence and

prevention of complications

P27

Chapter 3

Incidence and Clinical Significance of Cerebral Embolism during Atrial Fibrillation Ablation with Duty-Cycled Phased-RF versus

cooled-RF:

A Randomized Controlled Trial

P73

Chapter 5

Micro-embolic signals and Coagulation markers in ablation with the PVAC-Gold

and Thermocool catheter: results from the CE-AF trial

P115

Chapter 4

Biophysical parameters associated with micro-embolic signals using the PVAC-Gold catheter:

results from the CE-AF trial

P107 Part 2: Fr eedom fr om R ecurr ences Part 1: Fr eedom fr om Complic ations

(7)

Chapter 6

Optimizing ablation duration using dormant conduction to reveal incomplete isolation with the Second Generation Cryoballoon:

A Randomized Controlled Trial

P125 Chapter 9 Summary and Conclusions P183 Chapter 10 Samenvatting en Conclusies P193 Appendices List of abbreviations P207 List of publications P209 Dankwoord P211 Curriculum Vitae P215 Chapter 7

Predicting early reconnection after cryoballoon ablation with procedural and biophysical parameters

P143

Chapter 8

Impact of Left Atrial Box Surface Ratio on the Recurrence after

Ablation for Persistent Atrial Fibrillation

P161

Summar y and c

Referenties

Download het nu ( PDF - 7 pagina - 2.34 MB )

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