events to therapy
Graaf, Y.G.L. de
Citation
Graaf, Y. G. L. de. (2008, January 23). Skin carcinomas in organ-transplant recipients: from early oncogenic events to therapy. Department of Dermatology, Faculty of Medicine,
Leiden University Medical Center (LUMC), Leiden University. Retrieved from https://hdl.handle.net/1887/12579
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Skin carcinomas in organ-transplant recipients:
from early oncogenic events to therapy
Leontien de Graaf
1
Skin carcinomas in organ-transplant recipients:
from early oncogenic events to therapy
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 23 januari 2008 klokke 16.15 uur
door
Ymke Grete Leontien de Graaf
geboren te ’s Gravenhage in 1976
3
Promotor: Prof. dr. R. Willemze
Co-promotores: Dr. J.N. Bouwes Bavinck Dr. F.R. de Gruijl
Referent: Prof. dr. J.W. de Fijter
Overige Leden: Prof. dr. L. Mullenders Prof. dr. W. Spaan
Aan mijn ouders Aan Remko
5
Bauerfeind, Eucerin, Fagron B.V., Galderma, Glaxo Smith Kline, La Roche Posay, Leo Pharma, Louis Widmer, Meda Pharma B.V., Mölnlycke, Neutral huidverzorging, Novartis Pharma B.V., Roche, Schering-Plough, Vichy, and Wyeth Pharmaceuticals.
Skin carcinomas in organ-transplant recipients: from early oncogenic events to therapy
Thesis, Rijksuniversiteit Leiden, The Netherlands
¤ 2007, Leontien de Graaf, The Netherlands
CONTENTS
Chapter 1 General introduction 9
Chapter 2 More epidermal p53 patches adjacent to skin carcinomas in 21 renal-transplant recipients than in immunocompetent
individuals: the role of azathioprine
Chapter 3 p53-specific serum antibodies are not associated with a 31 history of skin carcinoma in renal-transplant recipients and
immunocompetent individuals
Chapter 4 UV-induced apoptosis is not diminished in the presence of 37 beta-papillomaviruses in habitually unexposed skin, but does
decrease with age
Chapter 5 Systemic and topical retinoids in the management of skin 51 cancer in organ-transplant recipients
Chapter 6 Photodynamic therapy does not prevent cutaneous squamous 59 cell carcinoma in organ-transplant recipients: results of a
randomized-controlled trial
Chapter 7 The occurrence of residual or recurrent squamous-cell carci- 67 nomas in organ-transplant recipients after curettage and
electrodessication
Chapter 8 Summary and general discussion 75
Appendices Nederlandse samenvatting 87
Curriculum vitae 93
Publicaties 97
Nawoord 101
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