Cover Page
The handle
http://hdl.handle.net/1887/136090
holds various files of this Leiden University
dissertation.
Author: Németh, B.
Title: Venous thrombosis following lower-leg cast immobilization and knee arthroscopy:
From a population-based approach to individualized therapy
Venous thrombosis following lower-leg cast
immobilization and knee arthroscopy
From a population-based approach to individualized therapy
Venous thrombosis following lower-leg cast
immobilization and knee arthroscopy
From a population-based approach to individualized therapy
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op woensdag 2 september 2020
klokke 16.15 uur door Banne Németh
geboren te Alphen aan den Rijn in 1987
Colophon
The research described in this thesis was performed at the Department of Clinical Epidemiology and the Department of Orthopaedic Surgery, Leiden University Medical Center, Leiden, The Netherlands.
Cover: Antony Nguyen
Lay-out and print: Gildeprint
ISBN: 978-94-6402-463-0
TABLE OF CONTENTS
Chapter 1 General introduction and outline of this thesis 7 Chapter 2 Thromboprophylaxis after knee arthroscopy and lower-leg
casting 15
Chapter 3 No indication for thromboprophylactic therapy following knee
arthroscopy or lower-leg casting 39
Chapter 4 High risk of recurrent venous thrombosis in patients with
lower-leg cast immobilization 49
Chapter 5 Risk and risk factors associated with recurrent venous thromboembolism following surgery in patients with history of venous thromboembolism
61 Chapter 6 Venous thrombosis risk after cast immobilization of the lower
extremity: derivation and validation of a clinical prediction score, L-TRiP(cast), in three population-based case–control studies
83
Chapter 7 Venous thromboembolism risk stratification for patients with nonsurgical lower-limb trauma requiring immobilization: a consensus decision-making aid, clinical model designed using the Delphi method
111
Chapter 8 Individualized thromboprophylaxis in patients with lower-leg cast immobilization – a validation and subgroup analysis in the POT-CAST trial
131 Chapter 9 Venous thrombosis risk after arthroscopy of the knee:
derivation and validation of the L-TRiP(ascopy) score 153 Chapter 10 Predicting venous thromboembolism risk after immobilization
of the lower-limb for trauma: update and validation of a clinical risk assessment model, the TRiP(cast) score
173 Chapter 11 Venous thrombosis following lower-leg cast immobilization
and knee arthroscopy: from a population-based approach to individualized therapy
195 Chapter 12 Summary and general discussion 235 Nederlandse samenvatting Dankwoord List of publications Curriculum vitae 245 255 261 271 Promotores Prof. dr. S.C. Cannegieter Prof. dr. R.G.H.H. Nelissen Leden promotiecommissie Prof. dr. F.R. Rosendaal Prof. dr. R.W. Poolman
Prof. dr. H.R. Büller (Amsterdam UMC)
