Cover Page
The handle
http://hdl.handle.net/1887/137444
holds various files of this Leiden University
dissertation.
Author:
Adrichem, R.A. van
Title: Thrombosis prophylaxis after knee arthroscopy or during lower leg cast
immobilization : determining the balance between benefits and risks
Thrombosis prophylaxis after knee arthroscopy or during
lower leg cast immobilization
Determining the balance between benefits and risks
Proefschrift
Door
The work described in this thesis was performed at the Department of Clinical Epidemiology and the Department of Orthopedic Surgery of the Leiden University Medical Center, the Netherlands
Research described in this thesis was supported by a grant of the Netherlands Organization for Health Research and Development (project number 171102001).
Cover design Rik Speel, Studio Speel
Thesis design David de Groot, persoonlijkproefschrift.nl Printed by Ridderprint, ridderprint.nl
ISBN: 978-94-6416-066-6
Copyright © 2020 R.A. van Adrichem, Leiden, the Netherlands. All rights reserved. No part of this publication may be reproduced, stored or transmitted in any form or by any means without prior permission in writing by the author.
The printing of this thesis was financially supported by the Nederlandse Orthopedische Vereniging, Bauerfeind, ChipSoft, Pfizer and Boehringer Ingelheim. All funding is gratefully acknowledged
Thrombosis prophylaxis after knee arthroscopy or during
lower leg cast immobilization
Determining the balance between benefits and risks
Proefschrift
ter verkrijging van
de graad van doctor aan de Universiteit Leiden, op gezag van de rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op woensdag 7 oktober 2020
Klokke 16.15 uur door
Raymond Alexander van Adrichem
Promotiecommissie
PromotoresProf. Dr. S.C. Cannegieter Prof. Dr. R.G.H.H. Nelissen
Leden promotiecommissie Prof. Dr. I.B. Schipper Prof. Dr. M.V. Huisman Prof. Dr. J.G. van der Bom
Dr. R.L.M. Deijkers (Reinier Haga Orthopedisch Centrum, Zoetermeer, Nederland) Dr. B. Siegerink (Charité Universitätsmedizin Berlin, Berlin, Germany)
Table of contents
Chapter Title Page
1 General introduction and outline of this thesis 7 2 Below-knee cast immobilization and the risk of venous
thrombosis: results from a large population-based case– control study
15
3 Risk of venous thrombosis after arthroscopy of the knee: results from a large population-based case–control study
37 4 Thromboprophylaxis for lower leg cast immobilization
and knee arthroscopy: a survey study
57 5 Prevention of venous thromboembolism during lower leg
cast immobilization: a randomized controlled trial
75 6 Prevention of venous thromboembolism after knee
arthroscopy: a randomized controlled trial
95 7 Venous thromboembolism prevention after anterior
cruciate ligament reconstruction: compression stocking with and without low molecular weight heparin
117
8 Venous thrombosis risk after cast immobilization of the lower extremity: derivation and validation of a clinical prediction score, L-TRiP(cast), in three population-based case–control studies
141
9 Venous thrombosis risk after arthroscopy of the knee: derivation and validation of the L-TRiP(ascopy) score
177
10 Summary and general discussion 201
11 List of publications 209
Nederlandse samenvatting (summary in Dutch) 214 Dankwoord (acknowledgements in Dutch) 220
