Reverse cholesterol transport : a potential therapeutic target for atherosclerosis
Zhao, Y.
Citation
Zhao, Y. (2011, November 1). Reverse cholesterol transport : a potential therapeutic target for atherosclerosis. Retrieved from https://hdl.handle.net/1887/18008
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/18008
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Curriculum vitae
Name: Ying Zhao Date of Birth: August 25, 1978
Place of Birth: Nanjing, Jiangsu Province, P.R. China
Sep 1993 - Jul 1996 Second Affiliated High School of Nanjing Normal University, Yizheng, P.R. China
Sep 1996 - Jul 2001 B.Sc. Dept. of Pharmacology for Chinese Materia Medica, China Pharmaceutical University, P.R. China (Graduation: July 1st, 2001)
Sep 2001 - Jun 2004 M.Sc., Dept. of Biological Science & Technology, Nanjing University, P.R. China (Graduation: Jun 15th, 2004) Supervisor: Prof. Dr. Qiang Xu
Sep 2004 - May 2005 Ph.D student, Dept. of Biology and Chemistry, City University of Hong Kong, P.R. China Supervisor: Prof. Dr. Wang-Fun Fong
Jun 2005 - Jun 2006 Mphil student, Dept. of Immunohematology and Blood
Transfusion, Leiden University Medical Center, The Netherlands Supervisor: Prof. Dr. Bart Roep
Co-Supervisor: Prof. Dr. Rene R.R.P. de Vires Aug 2006 - Nov 2010 Ph.D student at Division of Biopharmaceutics, LACDR, Leiden
University, The Netherlands (Promotion: Nov 1st, 2011)
Supervisor: Dr. Miranda van Eck Promoter: Prof. Dr. Theo J.C. van Berkel
Dec 2010 - Postdoctoral fellow at Division of Biopharmaceutics, LACDR, Leiden University, The Netherlands
Award and Honors
1996-1999 Undergraduate Scholarships (7 times)
2001 Outstanding Thesis of Bachelor’s Degree of China Pharmaceutical University
2004 BASF Scholarship of Nanjing University
2004 UGC Scholarship provided by Hong Kong Government 2005-2006 Leiden University Scholarship
2006 Best poster presentation at the LACDR Spring Symposium
Publications
Accepted manuscripts
Lammers B, Zhao Y, Hoekstra M, Hildebrand RB, Ye D, Meurs I, Van Berkel TJC, Van Eck M. Augmented atherogensis in LDL receptor deficiënt mice lacking both macrophage ABCA1 and apoE. PLoS One. 2011; in press
Zhao Y, Pennings M, Vrins CLJ, Calpe-Berdiel L, Hoekstra M, Kruijt JK, Ottenhoff R, Hildebrand RB, Van der Sluis R, Jessup W, Le Goff W, Chapman J, Huby T, Groen AK, Van Berkel TJC, Van Eck M. Hypocholestrolemia, foam cell formation, but no atherosclerosis in mice lack ABC-transporter A1 and scavenger receptor class B type I.
Atherosclerosis. 2011; 218: 314-322 (accompany by an editorial comment).
Foks AC, Frodermann V, Ter Borg M, Habets KL, Bot I, Zhao Y, van Eck M, van Berkel TJ, Kuiper J, van Puijvelde GH. Differential effects of regulatory T cells on the initiation and regression of atherosclerosis. Atherosclerosis. 2011; 218: 53-60.
Zhao Y, Ye D, Wang J, Calpe-Berdiel L, Azzis SB, Van Berkel TJ, Van Eck M. Stage- Specific Remodeling of Atherosclerotic Lesions on Cholesterol Lowering in LDL Receptor Knockout Mice. Am J Pathol. 2011; 179(3):1522-1532.
Ye D, Zhao Y, Hildebrand RB, Singaraja RR, Hayden MR, Van Berkel TJ, Van Eck M.
The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in low-density lipoprotein receptor knockout mice. Am J Pathol. 2011; 178 (1): 413-22.
Ye D, Lammers B, Zhao Y, Meurs I, Van Berkel TJ, Van Eck M. ATP-binding cassette transporters A1 and G1, HDL metabolism, cholesterol efflux, and inflammation: important targets for the treatment of atherosclerosis. Curr Drug Targets. 2011; 12 (5): 647-60.
Zhao Y, Pennings M, Hildebrand RB, Ye D, Calpe-Berdiel L, Out R, Kjerrulf M, Hurt- Camejo E, Groen AK, Hoekstra M, Jessup W, Chimini G, Van Berkel TJ, Van Eck M.
Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABCA1 and SR-BI in Bone marrow-derived cells in LDL receptor knockout mice on western-type diet. Circ Res. 2010; 107 (12): e20-31 (Cover Story).
Zhao Y, Van Berkel TJ, Van Eck M. Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions. Curr Opin Lipidol. 2010; 21 (5): 441-53.
Hoekstra M, Korporaal SJ, Li Z, Zhao Y, Van Eck M, Van Berkel TJ. Plasma lipoproteins are required for both basal and stress-induced adrenal glucocorticoid synthesis and protection against endotoxemia in mice. Am J Physiol Endocrinol Metab. 2010; 299 (6):
E1038-43.
Hildebrand RB, Lammers B, Meurs I, Korporaal SJ, De Haan W, Zhao Y, Kruijt JK, Praticò D, Schimmel AW, Holleboom AG, Hoekstra M, Kuivenhoven JA, Van Berkel TJ, Rensen PC, Van Eck M. Restoration of high-density lipoprotein levels by cholesteryl ester
does not normalize pathologies associated with SR-BI deficiency. Arterioscler Thromb Vasc Biol. 2010; 30 (7): 1439-45.
Ye D, Meurs I, Ohigashi M, Calpe-Berdiel L, Habets KL, Zhao Y, Kubo Y, Yamaguchi A, Van Berkel TJ, Nishi T, Van Eck M. Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice. Biochem Biophys Res Commun. 2010; 395 (3): 387-94.
Hoekstra M, Ye D, Hildebrand RB, Zhao Y, Lammers B, Stitzinger M, Kuiper J, Van Berkel TJ, Van Eck M. Scavenger receptor class B type I-mediated uptake of serum cholesterol is essential for optimal adrenal glucocorticoid production. J Lipid Res. 2009;
50 (6): 1039-46.
Out R, Jessup W, Le Goff W, Hoekstra M, Gelissen IC, Zhao Y, Kritharides L, Chimini G, Kuiper J, Chapman MJ, Huby T, Van Berkel TJ, Van Eck M. Coexistence of foam cells and hypocholesterolemia in mice lacking the ABC transporters A1 and G1. Circ Res. 2008;
102 (1): 113-20.
Xu L, Zhao Y, Qin Y, Xu Q. A novel model of acute liver injury in mice induced by T cell-mediated immune response to lactosylated bovine serum albumin. Clin Exp Immunol.
2006; 144 (1): 125-33.
Zhao Y, Liu J, Wang J, Wang L, Yin H, Tan R, Xu Q. Fumigaclavine C improves concanavalin A-induced liver injury in mice mainly via inhibiting TNF-alpha production and lymphocyte adhesion to extracellular matrices. J Pharm Pharmacol. 2004; 56 (6):
775-82.
Wu X, Zeng H, Zhang X, Zhao Y, Sha H, Ge X, Zhang M, Gao X, Xu Q. Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells. Am J Pathol. 2004; 164 (6): 2039-54.
Wang J, Zhao Y, Xu Q. Astilbin prevents concanavalin A-induced liver injury by reducing TNF-alpha production and T lymphocytes adhesion. J Pharm Pharmacol. 2004; 56 (4):
495-502.
Submitted manuscripts
Zhao Y, Wang J, Out R, Ye D, Van Berkel TJ, Van Eck M. ABCA1 deficiency induces macrophage foam cell formation and leukocytosis but inhibits early atheorsclerotic lesion development in SR-BI knockout mice.
Zhao Y, Calpe-Berdiel L, Wang J, Lammers B, Foks A, Van der Sluis R, Hildebrand RB, Van Berkel TJ, Van Eck M. Leukocyte ABCA1 and LDL receptor play independent roles in atherosclerosis: the potential contribution of T cells.
Zhao Y*, Calpe-Berdiel L*, Julve J, Escolà-Gil JC, Foks A, Van der Sluis RJ, Kuiper J, Blanco-Vaca F, Van Berkel TJC, Kuivenhoven JA, Van Eck M. Leukocyte ABC- transporter A1 is atheroprotective in absence of apolipoprotien AI (* These two authors contributed equally)
Zhao Y, Hildebrand RB, Van Berkel TJ, Van Eck M. High-Dose phosphatidylcholine particle mobilizes free cholesterol and rapidly stabilizes established atherosclerotic lesions.
Calpe-Berdiel L, Zhao Y, de Graauw M, Ye D, Van Santbrink PJ, Mommaas AM, Foks A, Bot M, Meurs I, Kuiper J, Mack JT, Van Eck M, Tew KD, Van Berkel TJC. Macrophage ABCA2 deletion modulates intracellular cholesterol deposition, affects macrophage apoptosis, and decreases early atherosclerosis in LDL receptor knockout mice.
Meurs I, Lammers B, Zhao Y, Out R, Hildebrand RB, Hoekstra M, Van Berkel TJC, Van Eck M. The effect of ABCG1 deficiency on atherosclerotic lesion development in LDL receptor knockout mice depends on the stage of atherosclerosis.
Habets KLL, Van Puijvelde GHM, Frodermann V, Zhao Y, de Vos P, Van Eck M, Van Berkel TJC, Kuiper J. Adoptive transfer of immature dentritic cells prevents progression of established atherosclerosis in LDL receptor knockout mice.
Meurs I, Calpe-Berdiel L, Habets KLL, Zhao Y, Korporaal SJA, Josselin E, Hildebrand RB, Ye D, Out R, Kuiper J, Van Berkel TJ, Chimini G, Van Eck M. Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1.
Published abstract
Hildebrand RB, Lammers B, Zhao Y, Jauhiainen M, Van Berkel TJC, Van Eck M.
Deletion of PLTP in SR-BI knockout mice shifts lipids from HDL to VLDL/LDL and reduces atherosclerosis. Circulation. 2010; 122: A15213.
Van Berkel TJC, Zhao Y, Hildebrand RB, Out R, Hoekstra M, Meurs I, Van Eck M.
Macrophage cholesterol homeostasis and atherosclerosis. Atherosclerosis Supp. 2009;
10(2): e140
Zhao Y, Out R, Ye D, Van Berkel TJC, Van Eck M. ABCA1 deficiency diminishes dysfunctional HDL and inhibits early atherosclerotic lesion development in SR-BI knockout mice. Circulation. 2008; 118: S_411.
Out R, Jessup W, Le Goff W, Hoekstra M, Gelissen IC, Zhao Y, Kritharides L, Chimini G, Kuiper J, Chapman MJ, Huby T, Van Berkel TJ, Van Eck M. The ABCs in foam cell formation. Arterioscler Thromb Vasc Biol. 2008; 28(6): E131
Van Eck M, Pennings M, Zhao Y, Hildebrand RB, Chimini G, Van Berkel TJC. Enhanced foam cell formation, inflammation, and atherosclerosis in LDL receptor knockout mice with a combined deletion of macrophage SR-BI and ABCA1. Circulation. 2007; 116: II- 298.
