Reverse cholesterol transport : a potential therapeutic target for atherosclerosis
Zhao, Y.
Citation
Zhao, Y. (2011, November 1). Reverse cholesterol transport : a potential therapeutic target for atherosclerosis. Retrieved from https://hdl.handle.net/1887/18008
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Reverse Cholesterol Transport
a potential therapeutic target for atherosclerosis
Ying Zhao
赵颖
ISBN: 978-90-8570-840-7
Printed by Wöhrmann Print Service – Zutphen
© 2011 Ying Zhao
Permissions to use the published articles were obtained from the indicated publishers.
All rights reserved. No part of this thesis may be reproduced or transmitted in any form, by any means, electronic or mechanical, without prior written permission of the author.
Reverse Cholesterol Transport
a potential therapeutic target for atherosclerosis
PROEFSCHRIFT
ter verkrijging van
de graad Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus Prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 1 november 2011
klokke 15.00 uur
door
Ying Zhao
Geboren te Nanjing, P.R. China in 1978
PROMOTIECOMMISSIE
Promotor: Prof. Dr. Th.J.C. van Berkel Co-promotor: Dr. M. van Eck
Overige leden : Prof. Dr. M. Danhof (Leiden/Amsterdam Center for Drug Research) Prof. Dr. M.J. Chapman (INSERM, Paris, France)
Prof. L.M. Havekes (Leiden University Medical Center)
Dr. J.A. Kuivenhoven (Academic Medical Center, Amsterdam)
The studies described in this thesis were performed at the Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University.
The research described in this thesis was supported by a grant of the Dutch Heart Foundation (DHF-2011T4101).
Financial support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged.
The printing of this thesis was financially supported by:
Leiden/Amsterdam Center for Drug Research J.E. Jurriaanse Stichting
TABLE OF CONTENTS
Abbreviations
Chapter 1 General introduction;
Chapter 2 Hypocholesterolemia, foam cell accumulation, but no atherosclerosis in mice lacking ABC-transporter A1 and scavenger receptor class B type I (Atherosclerosis. 2011, 218: 314-322)
Chapter 3 ABC-transporter A1 deficiency induces macrophage foam cell formation and leukocytosis but inhibits early atherosclerotic lesion development in scavenger receptor class B type I knockout mice
Chapter 4 Relative roles of various efflux pathways in net cholesterol efflux from macrophage foam cells in atherosclerotic lesions (Curr. Opin. Lipidol.
2010, 21: 441-453)
Chapter 5 Enhanced foam cell formation, atherosclerotic lesion development, and inflammation by combined deletion of ABC-transporter A1 and scavenger receptor class B type I in bone marrow-derived cells in LDL receptor knockout mice on Western-type diet (Circ. Res. 2010, 107: e20-31)
Chapter 6 Leukocyte ABC-transporter A1 and LDL receptor play independent roles in atherosclerosis: the potential contribution of T cells
Chapter 7 Leukocyte ABC-transporter A1 is atheroprotective in absence of apolipoprotein AI
Chapter 8 Stage-specific remodeling of atherosclerotic lesions upon cholesterol lowering in LDL receptor knockout mice (Am. J. Pathol. 2011, 179: 1522- 32)
Chapter 9 The dynamics of macrophage infiltration into the arterial wall during atherosclerotic lesion development in LDL receptor knockout mice (Am. J.
Pathol. 2011, 178:413-33)
Chapter 10 High-dose phosphatidylcholine particles mobilize free cholesterol and rapidly stabilize initial and advanced atherosclerotic lesions
Chapter 11 Summaries and perspectives Curriculum Vitae
Publications
ABBREVIATIONS
RCT: reverse cholesterol transport ABC: ATP-binding cassette ABCA1: ABC-transporter A1
SR-BI: scavenger receptor class B type 1 ABCG1: ABC-transporter G1
VLDL: very low-density lipoprotein LDL: low-density lipoprotein Ox-LDL: oxidized LDL Ac-LDL: acetylated LDL HDL: high-density lipoprotein apoAI: apolipoprotein AI apoE: apolipoprotein E PC: phosphatidylcholine LDLr: LDL receptor
LRP-1: LDL-related protein 1 WT: wild-type
KO: knockout -/-: KO
dKO: double KO
BMT: bone marrow transplantation WTD: Western-type diet
ATD: atherogenic diet FC: free cholesterol TC: total cholesterol CE: cholesteryl ester TG: triglycerides PL: phospholipids ID: injected dose
MCP-1: monocyte chemotactic protein-1 ICAM-1: inter-cellular adhesion molecule 1 KC: keratinocyte-derived chemokine
IL-12: interleukin 12 α-NT: α-nitrotyrosine
8-OHdG: α-8-hydroxy-2’-deoxyguanosine LXR: liver X receptor
SREBP: sterol regulatory element binding protein
