University of Groningen
Towards personalized medicine in pediatric inflammatory bowel disease Haisma, Sjoukje
DOI:
10.33612/diss.96888808
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Publication date: 2019
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Haisma, S. (2019). Towards personalized medicine in pediatric inflammatory bowel disease. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.96888808
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Towards personalized medicine in
pediatric inflammatory bowel
disease
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 9 oktober 2019 om 14.30 uur
door
Sjoukje-Marije Haisma
geboren op 26 juli 1991 te Opsterland
Promotor Prof. dr. H.J. Verkade Copromotor Dr. P.F. van Rheenen Beoordelingscommissie Prof. dr. J.C. Escher Prof. dr. G. Dijkstra Prof. dr. G.H. Koppelman
Promotor Prof. dr. H.J. Verkade Copromotor Dr. P.F. van Rheenen Beoordelingscommissie Prof. dr. J.C. Escher Prof. dr. G. Dijkstra Prof. dr. G.H. Koppelman Paranimfen Drs. T.P.C. Franke Dr. D.T. Talsma
CONTENTS
Chapter 1
General introduction and outline of this thesis.
Part I - Personalizing treatment
strategies
Chapter 2Fecal calprotectin for monitoring response to induction therapy in patients with active inflammatory bowel disease: a systematic review and meta-analysis.
Chapter 3
Time-to-reach target calprotectin level and relation with first relapse in newly diagnosed patients with IBD: first results of the Fast Forward Care Prospective Registry.
Chapter 4
Methotrexate for maintaining remission in pediatric Crohn’s patients with prior failure or intolerance to thiopurines: a mulitcenter cohort study.
Part II - Optimizing accuracy of fecal
calprotectin measurements in disease
monitoring
8 36 38 62 90 110Chapter 5
Calprotectin instability may lead to undertreatment in children with ibd. Chapter 6
Head-to-head comparison of three stool calprotectin tests for home use.
Part III - Profiling patients with
childhood-onset primary sclerosing
cholangitis
Chapter 7
Disease progression in paediatric‐ and adult‐ onset sclerosing cholangitis: Results from two independent Dutch registries.
Chapter 8
Exome sequencing in patient-parent trios reveals new candidate genes for early-onset primary sclerosing cholangitis.
Addendum
Chapter 9
General discussion and future perspectives. Chapter 10 Nederlandse Samenvatting Dankwoord List of publications 112 122 144 146 170 196 198 228
