University of Groningen Probiotic Bacteria and Their Encapsulation Evaluated in Advanced Co-culture Models Yuan, Lu

University of Groningen

Probiotic Bacteria and Their Encapsulation Evaluated in Advanced Co-culture Models Yuan, Lu

DOI:

10.33612/diss.160691131

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Publication date: 2021

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Yuan, L. (2021). Probiotic Bacteria and Their Encapsulation Evaluated in Advanced Co-culture Models. University of Groningen. https://doi.org/10.33612/diss.160691131

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Propositions 1. Advanced co-culture models of bacteria and tissue cells can reduce the number of animals used in the development of new antimicrobials. (this thesis) 2. Single-time point measurement of transepithelial electrical resistance for evaluating barrier integrity in a co-culture model does not represent the status of the system. (this thesis) 3. Probiotic bacteria offer an alternative method to treat infections with antimicrobial-resistant bacteria. (this thesis) 4.

Viable delivery of probiotic bacteria to an infected target-site is important in maintaining antimicrobial efficacy of probiotics. (this thesis) 5. The viability of encapsulated probiotic bacteria is

influenced by the interaction strength between the encapsulating shell and the bacterial cell wall. (this thesis) 6. Overgrowth of probiotics is destructive to an intestinal epithelial cell layer in vitro. (this thesis) 7. Data analysis of seemingly “useless” data is very important in research. 8. It is permissible to make mistakes, as long as you learn from them. 9. Open-access journals are friendly to researchers working from home, as compared with restrained access ones. 10. No man is an island entire of itself; every man is part of a continent. (John Donne) 11. When three men meet together, anyone of them who is anxious to learn will always be able to learn

something from the other two. (Confucius)