Cytokine responses to lipopolysaccharide in vivo and ex vivo : Genetic
polymorphisms and inter-individual variation
Schippers, E.F.
Citation
Schippers, E. F. (2006, June 27). Cytokine responses to lipopolysaccharide in vivo and ex vivo : Genetic polymorphisms and inter-individual variation. Retrieved from
https://hdl.handle.net/1887/4452
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4452
Cytokine responses to lipopolysaccharide
in vivo and ex vivo
Genetic polymorphisms and inter-individual variation
Cytokine responses to lipopolysaccharide
in vivo and ex vivo
Genetic polymorphisms and inter-individual variation
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Dr. D.D. Breimer,
hoogleraar in de faculteit de Wiskunde en Natuurwetenschappen en die der Geneeskunde, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 27 juni 2006 klokke 16:15 uur
door
Emile Frank Schippers geboren te Utrecht
Promotiecommissie
Promotor: Prof. Dr. J.T. van Dissel
Referent: Prof. Dr. T. van der Poll, Universiteit van Amsterdam Overige leden: Prof. Dr. P.C.M. van den Berg
Prof. Dr. W.A. Buurman, Universiteit van Maastricht Prof. Dr. T.W.J. Huizinga
When you get the choice to sit it out or dance I hope you dance (Mark D. Sanders/Tia Sillers, 1999)
© 2006 E.F. Schippers, Leiden, The Netherlands
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without permission from the copyright owner. ISBN-10: 90-9020635-3
ISBN-13: 978-90-9020635-6
Cover image: “Sepsis, veined into Oecology” by Eddie William Powell Printed by: Febodruk B.V. te Enschede
Contents
Chapter 1 General introduction and outline of the thesis 9 Chapter 2 No effect of preoperative selective gut decontamination on
endotoxemia and cytokine activation during cardiopulmonary bypass: a randomized, placebo-controlled study
Critical Care Medicine 2002; 30(1):38-43 31 Chapter 3 Letter to the Editor
Critical Care Medicine 2003; 31(1):334-5 39
Chapter 4 TNF-α and IL-10 production upon whole blood stimulation with a wide range of LPS concentrations: estimating an individual's dose-response characteristic described by the underlying receptor-ligand model
Submitted 45
Chapter 5 TNF-α promoter, Nod2 and toll-like receptor-4 polymorphisms and the in vivo and ex vivo response to endotoxin
Cytokine 2004; 26(1):16-24 63
Chapter 6 IL-10 and toll-like receptor-4 polymorphisms and in vivo and ex vivo response to endotoxin
Cytokine 2005; 29(5):215-28 75 Chapter 7 Cytokine response to endotoxin in individuals heterozygous for the
Delta32 mutation of chemokine receptor CCR5
Cytokine 2003; 21(4):195-9 91
Chapter 8 Polymorphisms in the TNF-α and IL-10 promoter region, TLR-4 of patients undergoing elective cardiac surgery
Submitted 99
Chapter 9 Summary and general discussion 117
Chapter 10 Nederlandse samenvatting 127
List of publications 133
Curriculum Vitae 137
Acknowledgements 139
