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Start small, think big: Growth monitoring, genetic analysis, treatment and quality
of life in children with growth disorders
Stalman, S.E.
Publication date
2016
Document Version
Final published version
Link to publication
Citation for published version (APA):
Stalman, S. E. (2016). Start small, think big: Growth monitoring, genetic analysis, treatment
and quality of life in children with growth disorders.
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Stellingen behorende bij het proefschrift
Start Small, Think Big
Diagnostic workup, genetic analysis, treatment and quality of life
in children with growth disorders
1. Guidelines are made to guide, but the most valuable guide for an individual medical assessment is the child itself. – this thesis
2. Given the wide variation of shapes of growth curves and the many possible underlying conditions, pursuing an ideal combination of criteria for growth monitoring might be infeasible. – this thesis
3. Future research should focus on the utility of performing additional investigations in children referred because of a suspected growth disorder and without clues for a specific diagnosis. – this thesis
4. Array-‐CGH to uncover copy number variations in the genetic diagnostic workup of SGA newborns should be performed before more expensive forms of genome wide analyses. – this thesis
5. Despite the many known positive effects of growth hormone treatment, quality of life in short children could be improved without the interference of growth hormone by preventing medicalisation or stigmatisation. – this thesis
6. Assessment of quality of life in patients with growth disorders should become part of care and research – this thesis
7. Doctors are good, exomes are better, doctors evaluating exomes are best. – Raoul Hennekam
8. When nothing goes right, go left. – Omdenken
9. Integrity is doing the right thing even when no one is watching. – C.S. Lewis
10. Logic will get you from A to B. Imagination will take you everywhere. – Albert Einstein 11. The pursuit of knowledge is never-‐ending. The day you stop seeking knowledge is the
day you stop growing – Bardon Travis Ciaccio
Stellingen behorende bij het proefschrift
Start Small, Think Big
Diagnostic workup, genetic analysis, treatment and quality of life
in children with growth disorders
1. Guidelines are made to guide, but the most valuable guide for an individual medical assessment is the child itself. – this thesis
2. Given the wide variation of shapes of growth curves and the many possible underlying conditions, pursuing an ideal combination of criteria for growth monitoring might be infeasible. – this thesis
3. Future research should focus on the utility of performing additional investigations in children referred because of a suspected growth disorder and without clues for a specific diagnosis. – this thesis
4. Array-‐CGH to uncover copy number variations in the genetic diagnostic workup of SGA newborns should be performed before more expensive forms of genome wide analyses. – this thesis
5. Despite the many known positive effects of growth hormone treatment, quality of life in short children could be improved without the interference of growth hormone by preventing medicalisation or stigmatisation. – this thesis
6. Assessment of quality of life in patients with growth disorders should become part of care and research – this thesis
7. Doctors are good, exomes are better, doctors evaluating exomes are best. – Raoul Hennekam
8. When nothing goes right, go left. – Omdenken
9. Integrity is doing the right thing even when no one is watching. – C.S. Lewis
10. Logic will get you from A to B. Imagination will take you everywhere. – Albert Einstein 11. The pursuit of knowledge is never-‐ending. The day you stop seeking knowledge is the
day you stop growing – Bardon Travis Ciaccio
Stellingen behorende bij het proefschrift
Start Small, Think Big
Diagnostic workup, genetic analysis, treatment and quality of life in children with growth disorders
1. Guidelines are made to guide, but the most valuable guide for an individual medical assessment is the child itself. – this thesis
2. Given the wide variation of shapes of growth curves and the many possible underlying conditions, pursuing an ideal combination of criteria for growth monitoring might be infeasible. – this thesis
3. Future research should focus on the utility of performing additional investigations in children referred because of a suspected growth disorder and without clues for a specific diagnosis. – this thesis
4. Array-‐CGH to uncover copy number variations in the genetic diagnostic workup of SGA newborns should be performed before more expensive forms of genome wide analyses. – this thesis
5. Despite the many known positive effects of growth hormone treatment, quality of life in short children could be improved without the interference of growth hormone by preventing medicalisation or stigmatisation. – this thesis
6. Assessment of quality of life in patients with growth disorders should become part of care and research – this thesis
7. Doctors are good, exomes are better, doctors evaluating exomes are best. – Raoul Hennekam
8. When nothing goes right, go left. – Omdenken
9. Integrity is doing the right thing even when no one is watching. – C.S. Lewis
10. Logic will get you from A to B. Imagination will take you everywhere. – Albert Einstein 11. The pursuit of knowledge is never-‐ending. The day you stop seeking knowledge is the
day you stop growing – Bardon Travis Ciaccio
Stellingen behorende bij het proefschrift
Start Small, Think Big
Diagnostic workup, genetic analysis, treatment and quality of life in children with growth disorders1. Guidelines are made to guide, but the most valuable guide for an individual medical assessment is the child itself. – this thesis
2. Given the wide variation of shapes of growth curves and the many possible underlying conditions, pursuing an ideal combination of criteria for growth monitoring might be infeasible. – this thesis
3. Future research should focus on the utility of performing additional
investigations in children referred because of a suspected growth disorder and without clues for a specific diagnosis. – this thesis
4. Array-CGH to uncover copy number variations in the genetic diagnostic workup of SGA newborns should be performed before more expensive forms of genome wide analyses. – this thesis
5. Despite the many known positive effects of growth hormone treatment, quality of life in short children could be improved without the interference of growth hormone by preventing medicalisation or stigmatisation. – this thesis 6. Assessment of quality of life in patients with growth disorders should become
part of care and research. – this thesis
7. Doctors are good, exomes are better, doctors evaluating exomes are best.
– Raoul Hennekam
8. When nothing goes right, go left. – Omdenken
9. Integrity is doing the right thing even when no one is watching. – C.S. Lewis 10. Logic will get you from A to B. Imagination will take you everywhere.
– Albert Einstein
11. The pursuit of knowledge is never-ending. The day you stop seeking knowledge is the day you stop growing. – Bardon Travis Ciaccio
