University of Groningen
Unravelling the molecular mechanisms underlying mitochondrial dysfunction in metabolic
diseases
Mposhi, Archibold
DOI:
10.33612/diss.146092791
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Mposhi, A. (2020). Unravelling the molecular mechanisms underlying mitochondrial dysfunction in metabolic diseases. University of Groningen. https://doi.org/10.33612/diss.146092791
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Stellingen
Behorende bij het proefschrift
Unravelling the molecular mechanisms underlying mitochondrial dysfunction in metabolic diseases
1. MtDNA methylation perturbs cellular lipid metabolism and is a likely cause of lipid accumulation in the liver. This thesis: Chapter 3
2. Increased mitochondrial DNA methylation associates with myopathy resulting in a decrease in ATP generating capacity in muscle. This thesis: Chapter 4
3. MtDNA methylation causes mitochondrial impairment, but cells develop compensation mechanisms to cope with this disruption in function. This thesis: Chapter 3 & 4
4. When carbon monoxide doesn’t kill you, it actually can make you stronger. This thesis: Chapter 5
5. When the forces of good turn evil. Inflammation disrupts lipid metabolism and aids to the development of non-alcoholic steatohepatitis (NASH). This thesis: Chapter 6
6. Our terminal decline into old age and death stems from the fine print of the contract that we signed with our mitochondria two billion years ago. — Nick Lane
7. In an era where truth is subjective and facts are ever changing, you never know whether you will stand on the right side of history.
8. As a citizen of the world, one’s truest accomplishment is feeling at home in a foreign land and seeing the world from a different perspective.
9. There is so much to do in Groningen and time moves fast, so before you know it your time is up and you haven’t yet climbed the Martini Tower.
Archibold Mposhi
