University of Groningen
Long-term effects of dietary lipid structure in early life
Ronda, Onne
DOI:
10.33612/diss.136676657
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Ronda, O. (2020). Long-term effects of dietary lipid structure in early life: Studies in experimental models. University of Groningen. https://doi.org/10.33612/diss.136676657
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Long-term effects of dietary
lipid structure in early life
Studies in experimental models
The research described in this thesis was conducted at the department of Pediatrics, section Molecular Metabolism and Nutrition, University Medical Center Groningen, The Netherlands. The studies in this thesis were financially supported by Danone Nutricia Research; the NorthStar project.
Printing of this thesis was financially supported by the University of Groningen, and the Graduate School of Medical Sciences.
Cover Design: © Onne Ronda, using a multi-scale patch-matching algorithm for style transfer, developed by Dr. David Tschumperlé (CNRS Institute), using adipose tissue histology and the painting “Petite Baie de La Ciotat” (1907) by Georges Braque.
ISBN (print): 978-94-034-2584-9
ISBN (online): 978-94-034-2585-6
© Onne A.H.O. Ronda | 2020
All rights reserved. No part of this publication may be reproduced, distributed, stored in a retrieval system, or transmitted, in any form or by any means, without permission of the author and the publisher holding respective copyrights of the published articles, if applicable.
Long-term effects of dietary
lipid structure in early life
Studies in experimental models
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 14 september 2020 om 12:45 uur
door
Onne Antonius Hendrikus Odilia Ronda
geboren op 03 januari 1991 te Maastricht
Promotores Prof. dr. H.J. Verkade Prof. dr. F. Kuipers Copromotor Dr. B.J.M. van de Heijning Beoordelingscommissie Prof. Dr. M. Müller Prof. Dr. G. van Dijk Prof. Dr. A.F. Bos
Paranimfen Agathe Esterle Fan Liu (刘帆)
What if we opened up the blinds and flew
away up to the skies? Let the snow and
wind and rain take away our sorrows and
pain.
Contents
Chapter 1 General introduction Outline of the thesis
7
Chapter 2 Programming effects of an early life diet containing large phospholipid-coated lipid globules are transient under continuous exposure to a high-fat diet
British Journal of Nutrition 2019; 122: 1321-1328
25
Chapter 3 Effects of an early life diet containing large phospholipid-coated lipid globules on hepatic lipid metabolism in mice
Submitted
45
Chapter 4 An early life diet containing large phospholipid-coated lipid globules programs later life postabsorptive lipid handling in high-fat diet but not in low-fat diet-fed mice
Submitted
67
Chapter 5 The impact of human milk cholesterol on the absorption of vitamin K1
In preparation
89
Chapter 6 Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet
Submitted
107
Chapter 7 General discussion and conclusion 149
Appendices Bibliography 174 Abbreviations 185 English summary 187 Nederlandse samenvatting 191 Dankwoord 195 Biografie 202 List of publications 205
