University of Groningen
Long-term effects of dietary lipid structure in early life
Ronda, Onne
DOI:
10.33612/diss.136676657
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Ronda, O. (2020). Long-term effects of dietary lipid structure in early life: Studies in experimental models.
University of Groningen. https://doi.org/10.33612/diss.136676657
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Appendices
Bibliography
Abbreviations
Summary
Samenvatting
Dankwoord
Biography
Biografie
List of publications
Bibliography
1. Michaud, C.M., C.J.L. Murray, and B.R. Bloom, Burden of Disease—Implications for Future Research. JAMA, 2001. 285(5): p. 535-539.
2. McKeown, R.E., The Epidemiologic Transition: Changing Patterns of Mortality and Population Dynamics.
American Journal of Lifestyle Medicine, 2009. 3(1_suppl): p. 19S-26S.
3. Ezzati, M. and E. Riboli, Behavioral and Dietary Risk Factors for Noncommunicable Diseases. New England Journal of Medicine, 2013. 369(10): p. 954-964.
4. Beaglehole, R. and D. Yach, Globalisation and the prevention and control of non-communicable disease: the
neglected chronic diseases of adults. The Lancet, 2003. 362(9387): p. 903-908.
5. Hyseni, L., et al., The effects of policy actions to improve population dietary patterns and prevent diet-related
non-communicable diseases: scoping review. European Journal of Clinical Nutrition, 2017. 71(6): p. 694-711.
6. Swinburn, B.A., et al., Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am J Clin Nutr, 2009. 89(6): p. 1723-8.
7. Westhoek, H., et al., Food choices, health and environment: Effects of cutting Europe's meat and dairy intake. Global Environmental Change, 2014. 26: p. 196-205.
8. Ronda, O.A.H.O., et al., Programming effects of an early life diet containing large phospholipid-coated lipid
globules are transient under continuous exposure to a high-fat diet. British Journal of Nutrition, 2019.
122(12): p. 1321-1328.
9. Baars, A., et al., Milk fat globule membrane coating of large lipid droplets in the diet of young mice prevents
body fat accumulation in adulthood. British Journal of Nutrition, 2016. 115(11): p. 1930-1937.
10. Hochberg, Z., et al., Child Health, Developmental Plasticity, and Epigenetic Programming. Endocrine Reviews, 2011. 32(2): p. 159-224.
11. Stein, A.D. and L.H. Lumey, The relationship between maternal and offspring birth weights after maternal
prenatal famine exposure: the Dutch Famine Birth Cohort Study. Hum Biol, 2000. 72(4): p. 641-54.
12. Persson, P.B. and A.B. Persson, Foetal programming. Acta Physiologica, 2019. 0(0): p. e13403. 13. Stein, Z., et al., Famine and human development: The Dutch hunger winter of 1944-1945. 1975. 14. Stein, Z. and M. Susser, The Dutch Famine, 1944–1945, and the Reproductive Process. I. Effects on Six
Indices at Birth. Pediatric Research, 1975. 9(2): p. 70-76.
15. Ravelli, A.C.J., et al., Obesity at the age of 50 y in men and women exposed to famine prenatally. The American Journal of Clinical Nutrition, 1999. 70(5): p. 811-816.
16. Barker, D.J., et al., Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol, 2002. 31(6): p. 1235-9.
17. Armitage, J.A., P.D. Taylor, and L. Poston, Experimental models of developmental programming:
consequences of exposure to an energy rich diet during development. The Journal of Physiology, 2005.
565(1): p. 3-8.
18. Koletzko, B., et al., Can infant feeding choices modulate later obesity risk? The American Journal of Clinical Nutrition, 2009. 89(5): p. 1502S-1508S.
19. Dewey, K.G., Is breastfeeding protective against child obesity? J Hum Lact, 2003. 19(1): p. 9-18.
20. Lucas, A., Programming by early nutrition in man. Ciba Found Symp, 1991. 156: p. 38-50; discussion 50-5. 21. Vickers, M.H., Early Life Nutrition, Epigenetics and Programming of Later Life Disease. Nutrients, 2014.
6(6): p. 2165-2178.
22. Liu, H.-W., et al., Developmental programming in skeletal muscle in response to overnourishment in the
immediate postnatal life in rats. The Journal of Nutritional Biochemistry, 2013. 24(11): p. 1859-1869.
23. He, J., et al., Methylation levels at IGF2 and GNAS DMRs in infants born to preeclamptic pregnancies. BMC genomics, 2013. 14: p. 472-472.
24. Arenz, S., et al., Breast-feeding and childhood obesity--a systematic review. Int J Obes Relat Metab Disord, 2004. 28(10): p. 1247-56.
25. Gillman, M.W., et al., Risk of overweight among adolescents who were breastfed as infants. Journal of the American Medical Association, 2001. 285(19): p. 2461-7.
26. Owen, C.G., et al., Infant feeding and blood cholesterol: a study in adolescents and a systematic review. Pediatrics, 2002. 110(3): p. 597-608.
27. Owen, C.G., et al., Effect of breast feeding in infancy on blood pressure in later life: systematic review and
meta-analysis. Bmj, 2003. 327(7425): p. 1189-95.
28. Horwood, L.J. and D.M. Fergusson, Breastfeeding and Later Cognitive and Academic Outcomes. Pediatrics, 1998. 101(1): p. e9-e9.
29. Walfisch, A., et al., Breast milk and cognitive development—the role of confounders: a systematic review. BMJ Open, 2013. 3(8): p. e003259.
30. Horta, B.L., C. Loret de Mola, and C.G. Victora, Breastfeeding and intelligence: a systematic review and
A
31. Allen, J. and D. Hector, Benefits of breastfeeding. New South Wales Public Health Bulletin, 2005. 16(4): p. 42-46.
32. Chang, E., et al., Programming effects of maternal and gestational obesity on offspring metabolism and
metabolic inflammation. Scientific Reports, 2019. 9(1): p. 16027.
33. Nicholas, L.M. and S.E. Ozanne, Early life programming in mice by maternal overnutrition: mechanistic
insights and interventional approaches. Philosophical Transactions of the Royal Society B: Biological
Sciences, 2019. 374(1770): p. 20180116.
34. Patel, M.S. and M. Srinivasan, Metabolic programming in the immediate postnatal life. Annals of nutrition & metabolism, 2011. 58 Suppl 2(Suppl 2): p. 18-28.
35. Ferretti, F. and M. Mariani, Sugar-sweetened beverage affordability and the prevalence of overweight and
obesity in a cross section of countries. Globalization and Health, 2019. 15(1): p. 30.
36. Nigatu, Y.T., et al., The Combined Effects of Obesity, Abdominal Obesity and Major Depression/Anxiety on
Health-Related Quality of Life: the LifeLines Cohort Study. PLOS ONE, 2016. 11(2): p. e0148871.
37. Sarría, A., et al., Skinfold thickness measurements are better predictors of body fat percentage than body mass
index in male Spanish children and adolescents. European Journal of Clinical Nutrition, 1998. 52(8): p.
573-576.
38. Dencker, M., et al., BMI and objectively measured body fat and body fat distribution in prepubertal children. Clinical Physiology and Functional Imaging, 2007. 27(1): p. 12-16.
39. Daniels, S.R., P.R. Khoury, and J.A. Morrison, The utility of body mass index as a measure of body fatness in
children and adolescents: differences by race and gender. Pediatrics, 1997. 99(6): p. 804-7.
40. Taylor Jr, H.A., et al., Relationships of BMI to Cardiovascular Risk Factors Differ by Ethnicity. Obesity, 2010. 18(8): p. 1638-1645.
41. Fontana, L., et al., Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in
humans. Proceedings of the National Academy of Sciences of the United States of America, 2004. 101(17): p.
6659-6663.
42. Sahoo, K., et al., Childhood obesity: causes and consequences. Journal of family medicine and primary care, 2015. 4(2): p. 187-192.
43. van Vliet-Ostaptchouk, J.V., et al., The prevalence of metabolic syndrome and metabolically healthy obesity
in Europe: a collaborative analysis of ten large cohort studies. BMC endocrine disorders, 2014. 14: p. 9-9.
44. Blackburn, G.L. and W.A. Walker, Science-based solutions to obesity: what are the roles of academia,
government, industry, and health care? The American Journal of Clinical Nutrition, 2005. 82(1): p.
207S-210S.
45. Egger, G. and B. Swinburn, An “ecological” approach to the obesity pandemic. 1997. 315(7106): p. 477-480. 46. Frieden, T.R. and M.R. Bloomberg, How to prevent 100 million deaths from tobacco. The Lancet, 2007.
369(9574): p. 1758-1761.
47. White, V.M., et al., What impact have tobacco control policies, cigarette price and tobacco control
programme funding had on Australian adolescents' smoking? Findings over a 15-year period. Addiction,
2011. 106(8): p. 1493-1502.
48. Cole, T.J., et al., Establishing a standard definition for child overweight and obesity worldwide: international
survey. Bmj, 2000. 320(7244): p. 1240-3.
49. Cameron, N., Body mass index cut offs to define thinness in children and adolescents. BMJ (Clinical research ed.), 2007. 335(7612): p. 166-167.
50. Martin, C.R., P.-R. Ling, and G.L. Blackburn, Review of Infant Feeding: Key Features of Breast Milk and
Infant Formula. Nutrients, 2016. 8(5): p. 279.
51. Greer, F.R., Vitamin K in human milk--still not enough. Acta Paediatr, 2004. 93(4): p. 449-50.
52. van Hasselt, P.M., et al., Prevention of vitamin K deficiency bleeding in breastfed infants: lessons from the
Dutch and Danish biliary atresia registries. Pediatrics, 2008. 121(4): p. e857-63.
53. Witt, M., et al., Prophylactic Dosing of Vitamin K to Prevent Bleeding. Pediatrics, 2016.
54. Lanting, C.I., J.P. van Wouwe, and S.A. Reijneveld, Infant milk feeding practices in the Netherlands and
associated factors. Acta Paediatrica, 2005. 94(7): p. 935-942.
55. Kohlhuber, M., et al., Breastfeeding rates and duration in Germany: a Bavarian cohort study. Br J Nutr, 2008. 99(5): p. 1127-32.
56. Agostoni, C., et al., Breast-feeding: A Commentary by the ESPGHAN Committee on Nutrition. Journal of Pediatric Gastroenterology and Nutrition, 2009. 49(1): p. 112-125.
57. Andreas, N.J., B. Kampmann, and K. Mehring Le-Doare, Human breast milk: A review on its composition
and bioactivity. Early Human Development, 2015. 91(11): p. 629-635.
58. Uwaezuoke, S.N., C.I. Eneh, and I.K. Ndu, Relationship Between Exclusive Breastfeeding and Lower Risk of
Childhood Obesity: A Narrative Review of Published Evidence. Clinical medicine insights. Pediatrics, 2017.
11: p. 1179556517690196-1179556517690196.
59. Gallier, S., et al., A novel infant milk formula concept: Mimicking the human milk fat globule structure. Colloids and Surfaces B: Biointerfaces, 2015. 136: p. 329-339.
60. Olafsdottir, A.S., et al., Fat-Soluble Vitamins in the Maternal Diet, Influence of Cod Liver Oil
Supplementation and Impact of the Maternal Diet on Human Milk Composition. Annals of Nutrition and
Metabolism, 2001. 45(6): p. 265-272.
61. Keikha, M., et al., Macro- and Micronutrients of Human Milk Composition: Are They Related to Maternal
Diet? A Comprehensive Systematic Review. Breastfeeding Medicine, 2017. 12(9): p. 517-527.
62. Gantner, V., et al., The overall and fat composition of milk of various species. Mljekarstvo/Dairy, 2015. 65(4): p. 223-231.
63. Yuhas, R., K. Pramuk, and E.L. Lien, Human milk fatty acid composition from nine countries varies most in
DHA. Lipids, 2006. 41(9): p. 851-858.
64. Witkowska-Zimny, M. and E. Kaminska-El-Hassan, Cells of human breast milk. Cellular & molecular biology letters, 2017. 22: p. 11-11.
65. Patton, S. and T.W. Keenan, The Milk fat globule membrane. Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1975. 415(3): p. 273-309.
66. Lee, H., et al., Compositional Dynamics of the Milk Fat Globule and Its Role in Infant Development. Frontiers in Pediatrics, 2018. 6(313).
67. Fedotova, Y. and R.W. Lencki, The Effect of Phospholipids on Milkfat Crystallization Behavior. Journal of the American Oil Chemists' Society, 2008. 85(3): p. 205-212.
68. Bourlieu, C. and M.C. Michalski, Structure-function relationship of the milk fat globule. Curr Opin Clin Nutr Metab Care, 2015. 18(2): p. 118-27.
69. Michalski, M.C., et al., Size Distribution of Fat Globules in Human Colostrum, Breast Milk, and Infant
Formula. Journal of Dairy Science, 2005. 88(6): p. 1927-1940.
70. Gopakumar, H., R. Sivji, and P.K. Rajiv, Vitamin K deficiency bleeding presenting as impending brain
herniation. Journal of Pediatric Neurosciences, 2010. 5(1): p. 55-58.
71. Yamanashi, Y., et al., Transporters for the Intestinal Absorption of Cholesterol, Vitamin E, and Vitamin K. Journal of atherosclerosis and thrombosis, 2017. 24(4): p. 347-359.
72. Ahern, G.J., et al., Advances in Infant Formula Science. Annual Review of Food Science and Technology, 2019. 10(1): p. 75-102.
73. Koletzko, B., R. Shamir, and M. Ashwell, Quality and Safety Aspects of Infant Nutrition. Annals of Nutrition and Metabolism, 2012. 60(3): p. 179-184.
74. Weaver, L.T., Improving Infant Milk Formulas: Near the End of the Trail for the Holy Grail? Journal of Pediatric Gastroenterology and Nutrition, 2003. 36(3): p. 307-310.
75. Soliman, G.Z., Comparison of chemical and mineral content of milk from human, cow, buffalo, camel and
goat in Egypt. Egypt J. Hosp. Med, 2005. 21: p. 116-130.
76. Hageman, J.H.J., et al., Comparison of bovine milk fat and vegetable fat for infant formula: Implications for
infant health. International Dairy Journal, 2019. 92: p. 37-49.
77. Kunz, C. and B. Lönnerdal, Re-evaluation of the whey protein/casein ratio of human milk. Acta Paediatrica, 1992. 81(2): p. 107-112.
78. Lara-Villoslada, F., M. Olivares, and J. Xaus, The Balance Between Caseins and Whey Proteins in Cow's Milk
Determines its Allergenicity. Journal of Dairy Science, 2005. 88(5): p. 1654-1660.
79. Vanderghem, C., et al., Milk fat globule membrane and buttermilks: from composition to valorization. Base, 2010.
80. Oosting, A., et al., Size and phospholipid coating of lipid droplets in the diet of young mice modify body fat
accumulation in adulthood. Pediatr Res, 2012. 72(4): p. 362-9.
81. Hinde, K. and L.A. Milligan, Primate milk: Proximate mechanisms and ultimate perspectives. Evolutionary Anthropology: Issues, News, and Reviews, 2011. 20(1): p. 9-23.
82. Oftedal, O. and S. Iverson, Phylogenetic variation in the gross composition of milks. Handbook of Milk
Composition. 1995, Academic Press Inc., San Diego, California, USA. p. 749–788.
83. Lovejoy, C.O., The origin of man. Science, 1981. 211(4480): p. 341-50.
84. Kennedy, G.E., Palaeolithic Grandmothers? Life History Theory and Early Homo. Journal of the Royal Anthropological Institute, 2003. 9(3): p. 549-572.
85. Argov, N., D.G. Lemay, and J.B. German, Milk fat globule structure and function: nanoscience comes to milk
production. Trends in Food Science & Technology, 2008. 19(12): p. 617-623.
86. German, J.B., C.J. Dillard, and R.E. Ward, Bioactive components in milk. Current Opinion in Clinical Nutrition & Metabolic Care, 2002. 5(6): p. 653-658.
87. German, J.B. and C.J. Dillard, Composition, Structure and Absorption of Milk Lipids: A Source of Energy,
Fat-Soluble Nutrients and Bioactive Molecules. Critical Reviews in Food Science and Nutrition, 2006. 46(1):
p. 57-92.
88. Hamosh, M., Introduction: Should Infant Formulas Be Supplemented with Bioactive Components and
Conditionally Essential Nutrients Present in Human Milk? The Journal of Nutrition, 1997. 127(5): p.
A
89. Hinde, K., M.L. Power, and O.T. Oftedal, Rhesus macaque milk: magnitude, sources, and consequences of
individual variation over lactation. American journal of physical anthropology, 2009. 138(2): p. 148-157.
90. Robson, S.L., C.P. Van Schaik, and K. Hawkes, The derived features of human life history. The evolution of human life history, 2006. 17.
91. Lee, P.C., P. Majluf, and I.J. Gordon, Growth, weaning and maternal investment from a comparative
perspective. Journal of Zoology, 1991. 225(1): p. 99-114.
92. Grote, V., et al., Protein Intake and Growth in the First 24 Months of Life. Journal of Pediatric Gastroenterology and Nutrition, 2010. 51: p. S117-S118.
93. Dimova, L.G., et al., Inhibiting Cholesterol Absorption During Lactation Programs Future Intestinal
Absorption of Cholesterol in Adult Mice. Gastroenterology, 2017. 153(2): p. 382-385.e3.
94. Dimova, L.G., et al., Reduced Dietary Cholesterol Availability in Infancy Programs Cholesterol Absorption in
Adult Mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 2016. 36(suppl_1): p. A621-A621.
95. Teller, I.C., et al., Differences in Postprandial Lipid Response to Breast- or Formula-feeding in 8-Week-Old
Infants. Journal of Pediatric Gastroenterology and Nutrition, 2017. 64(4): p. 616-623.
96. Oosting, A., et al., Effect of dietary lipid structure in early postnatal life on mouse adipose tissue development
and function in adulthood. Br J Nutr, 2014. 111(2): p. 215-26.
97. Vors, C., et al., Modulating absorption and postprandial handling of dietary fatty acids by structuring fat in
the meal: a randomized crossover clinical trial. Am J Clin Nutr, 2013. 97(1): p. 23-36.
98. Schipper, L., et al., 1065 Adult Body Fat Accumulation is Not Affected by Adding Phospholipid ingredient and
Only Marginally By Lipid-Droplet Size in the Postnatal Diet. Pediatric Research, 2010. 68: p. 529.
99. Bertram, C.E. and M.A. Hanson, Animal models and programming of the metabolic syndrome: Type 2
diabetes. British Medical Bulletin, 2001. 60(1): p. 103-121.
100. Patten, A.R., C.J. Fontaine, and B.R. Christie, A comparison of the different animal models of fetal alcohol
spectrum disorders and their use in studying complex behaviors. Frontiers in pediatrics, 2014. 2: p. 93-93.
101. West, J.R., Use of pup in a cup model to study brain development. J Nutr, 1993. 123(2 Suppl): p. 382-5. 102. Dutta, S. and P. Sengupta, Men and mice: Relating their ages. Life Sciences, 2016. 152: p. 244-248. 103. West, D.B., et al., Dietary obesity in nine inbred mouse strains. American Journal of Physiology-Regulatory,
Integrative and Comparative Physiology, 1992. 262(6): p. R1025-R1032.
104. Riphagen, I.J., et al., Measurement of plasma vitamin K1 (phylloquinone) and K2 (menaquinones-4 and -7)
using HPLC-tandem mass spectrometry. Clin Chem Lab Med, 2016. 54(7): p. 1201-10.
105. Hirota, Y., et al., Menadione (vitamin K3) is a catabolic product of oral phylloquinone (vitamin K1) in the
intestine and a circulating precursor of tissue menaquinone-4 (vitamin K2) in rats. The Journal of biological
chemistry, 2013. 288(46): p. 33071-33080.
106. Mandelbrot, L., et al., Placental transfer of vitamin K1 and its implications in fetal hemostasis. Thromb Haemost, 1988. 60(1): p. 39-43.
107. Kazzi, N.J., et al., Placental transfer of vitamin K1 in preterm pregnancy. Obstet Gynecol, 1990. 75(3 Pt 1): p. 334-7.
108. Gentili, A., et al., Comprehensive profiling of carotenoids and fat-soluble vitamins in milk from different
animal species by LC-DAD-MS/MS hyphenation. J Agric Food Chem, 2013. 61(8): p. 1628-39.
109. van Hasselt, P.M., et al., Hydrolysed formula is a risk factor for vitamin K deficiency in infants with
unrecognised cholestasis. J Pediatr Gastroenterol Nutr, 2010. 51(6): p. 773-6.
110. Van Winckel, M., et al., Vitamin K, an update for the paediatrician. Eur J Pediatr, 2009. 168(2): p. 127-34. 111. Mihatsch, W.A., et al., Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by
the ESPGHAN Committee on Nutrition. J Pediatr Gastroenterol Nutr, 2016. 63(1): p. 123-9.
112. Amedee-Manesme, O., et al., Pharmacokinetics and safety of a new solution of vitamin K1(20) in children
with cholestasis. J Pediatr Gastroenterol Nutr, 1992. 14(2): p. 160-5.
113. Pereira, S.P., et al., Intestinal absorption of mixed micellar phylloquinone (vitamin K1) is unreliable in infants
with conjugated hyperbilirubinaemia: implications for oral prophylaxis of vitamin K deficiency bleeding.
Archives of Disease in Childhood - Fetal and Neonatal Edition, 2003. 88(2): p. F113.
114. Goncalves, A., et al., Intestinal scavenger receptors are involved in vitamin K1 absorption. The Journal of biological chemistry, 2014. 289(44): p. 30743-30752.
115. Armand, M., et al., Effect of Human Milk or Formula on Gastric Function and Fat Digestion in the
Premature Infant. Pediatric Research, 1996. 40: p. 429.
116. Bourlieu, C., et al., The structure of infant formulas impacts their lipolysis, proteolysis and disintegration
during in vitro gastric digestion. Food Chem, 2015. 182: p. 224-35.
117. Pettersson, U.S., et al., Female mice are protected against high-fat diet induced metabolic syndrome and
increase the regulatory T cell population in adipose tissue. PLoS One, 2012. 7(9): p. e46057.
118. Reeves, P.G., F.H. Nielsen, and G.C. Fahey, Jr., AIN-93 purified diets for laboratory rodents: final report of
the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet.
119. Cariou, B., et al., The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice. J Biol Chem, 2006. 281(16): p. 11039-49.
120. Doktorova, M., et al., Intestinal PPARdelta protects against diet-induced obesity, insulin resistance and
dyslipidemia. Sci Rep, 2017. 7(1): p. 846.
121. Verkade, H.J., et al., Fat absorption in neonates: comparison of long-chain-fatty-acid and triglyceride
compositions of formula, feces, and blood. Am J Clin Nutr, 1991. 53(3): p. 643-51.
122. Dimova, L.G., et al., Inhibiting Cholesterol Absorption During Lactation Programs Future Intestinal
Absorption of Cholesterol in Adult Mice. Gastroenterology, 2017. 153(2): p. 382-385.e3.
123. Kleiner, D.E., et al., Design and validation of a histological scoring system for nonalcoholic fatty liver
disease. Hepatology, 2005. 41(6): p. 1313-21.
124. Lackner, C., Hepatocellular ballooning in nonalcoholic steatohepatitis: the pathologist's perspective. Expert Rev Gastroenterol Hepatol, 2011. 5(2): p. 223-31.
125. Sutton, M.E., et al., Regeneration of human extrahepatic biliary epithelium: the peribiliary glands as
progenitor cell compartment. Liver International, 2012. 32(4): p. 554-559.
126. Gentric, G., et al., Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease. J Clin Invest, 2015. 125(3): p. 981-92.
127. Galarraga, M., et al., Adiposoft: automated software for the analysis of white adipose tissue cellularity in
histological sections. J Lipid Res, 2012. 53(12): p. 2791-6.
128. Greaves, P., et al., Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle
and mesothelium. J Toxicol Pathol, 2013. 26(3 Suppl): p. 1s-26s.
129. Rosner, B., Fundamentals of biostatistics. 2015, Toronto, Canada: Nelson Education.
130. Kotronen, A., et al., Comparison of lipid and fatty acid composition of the liver, subcutaneous and
intra-abdominal adipose tissue, and serum. Obesity (Silver Spring), 2010. 18(5): p. 937-44.
131. Jump, D.B., Fatty acid regulation of hepatic lipid metabolism. Curr Opin Clin Nutr Metab Care, 2011. 14(2): p. 115-20.
132. Finley, D.A., et al., Breast milk composition: fat content and fatty acid composition in vegetarians and
non-vegetarians. Am J Clin Nutr, 1985. 41(4): p. 787-800.
133. Kelishadi, R., et al., A study on lipid content and fatty acid of breast milk and its association with mother's
diet composition. J Res Med Sci, 2012. 17(9): p. 824-7.
134. Vurma, M., S. DeMichele, and P. Tso, Comparison of fat absorption mechanisms in vivo between human milk
and infant formula containing novel absorption enhancement technology. Journal of Pediatric
Gastroenterology and Nutrition, 2018. 66: p. 1096.
135. Baumgartner, S., et al., Infant milk fat droplet size and coating affect postprandial responses in healthy adult
men: a proof-of-concept study. Eur J Clin Nutr, 2017. 71(9): p. 1108-1113.
136. Werner, A., et al., Lymphatic chylomicron size is inversely related to biliary phospholipid secretion in mice. American Journal of Physiology - Gastrointestinal and Liver Physiology, 2006. 290(6): p. G1177-G1185. 137. Goldberg, I.J., Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis.
Journal of Lipid Research, 1996. 37(4): p. 693-707.
138. Martins, I., et al., Effects of particle size and number on the plasma clearance of chylomicrons and remnants. Journal of lipid research, 1996. 37(12): p. 2696-2705.
139. Braet, F. and E. Wisse, Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a
review. Comp Hepatol, 2002. 1(1): p. 1.
140. Hamdy, O., S. Porramatikul, and E. Al-Ozairi, Metabolic obesity: the paradox between visceral and
subcutaneous fat. Curr Diabetes Rev, 2006. 2(4): p. 367-73.
141. Vickers, M.H., et al., Neonatal Leptin Treatment Reverses Developmental Programming. Endocrinology, 2005. 146(10): p. 4211-4216.
142. Singhal, A., Long-Term Adverse Effects of Early Growth Acceleration or Catch-Up Growth. Annals of Nutrition and Metabolism, 2017. 70(3): p. 236-240.
143. Picó, C., et al., Metabolic programming of obesity by energy restriction during the perinatal period: different
outcomes depending on gender and period, type and severity of restriction. Frontiers in physiology, 2012. 3:
p. 436-436.
144. Wells, J.C.K., The evolution of human adiposity and obesity: where did it all go wrong? Disease Models & Mechanisms, 2012. 5(5): p. 595.
145. Frühbeck, G., et al., Adiponectin-leptin ratio: A promising index to estimate adipose tissue dysfunction.
Relation with obesity-associated cardiometabolic risk. Adipocyte, 2018. 7(1): p. 57-62.
146. Marchini, G., et al., Plasma Leptin in Infants: Relations to Birth Weight and Weight Loss. Pediatrics, 1998.
101(3): p. 429-432.
147. Smith, R.L., et al., Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health
and Disease. Endocrine Reviews, 2018. 39(4): p. 489-517.
148. van Zutphen, T., et al., Farnesoid X Receptor alters adipose tissue architecture in mice and limits storage
A
149. Mercer, K.E., et al., Programming Effects of Infant Diet on Cholesterol/Bile Acid Synthesis and Absorption in
Piglets. The FASEB Journal, 2016. 30(1_supplement): p. 267.6-267.6.
150. Wang, Z., et al., Specific metabolic rates of major organs and tissues across adulthood: evaluation by
mechanistic model of resting energy expenditure. The American journal of clinical nutrition, 2010. 92(6): p.
1369-1377.
151. Kummitha, C.M., et al., Relating tissue/organ energy expenditure to metabolic fluxes in mouse and human:
experimental data integrated with mathematical modeling. Physiological reports, 2014. 2(9): p. e12159.
152. Morris, E.M., et al., PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced
triacylglycerol accumulation and secretion. American journal of physiology. Gastrointestinal and liver
physiology, 2012. 303(8): p. G979-G992.
153. Muoio, D.M. and T.R. Koves, Lipid-induced metabolic dysfunction in skeletal muscle. Novartis Found Symp, 2007. 286: p. 24-38; discussion 38-46, 162-3, 196-203.
154. Nagy, R.A., et al., Presence of bile acids in human follicular fluid and their relation with embryo development
in modified natural cycle IVF. Hum Reprod, 2015. 30(5): p. 1102-9.
155. Derks, T.G.J., et al., Neonatal screening for medium-chain acyl-CoA dehydrogenase (MCAD) deficiency in
The Netherlands: The importance of enzyme analysis to ascertain true MCAD deficiency. Journal of Inherited
Metabolic Disease, 2008. 31(1): p. 88-96.
156. Wolters, J.C., et al., Translational Targeted Proteomics Profiling of Mitochondrial Energy Metabolic
Pathways in Mouse and Human Samples. J Proteome Res, 2016. 15(9): p. 3204-13.
157. Liang, H., et al., Gpx4 protects mitochondrial ATP generation against oxidative damage. Biochemical and Biophysical Research Communications, 2007. 356(4): p. 893-898.
158. Qiu, X., et al., Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation. Cell Metabolism, 2010. 12(6): p. 662-667.
159. van Zutphen, T., et al., Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal
and mitochondrial dysfunction. Journal of Hepatology, 2016. 65(6): p. 1198-1208.
160. Fiorese, C.J., et al., The Transcription Factor ATF5 Mediates a Mammalian Mitochondrial UPR. Curr Biol, 2016. 26(15): p. 2037-2043.
161. Park, H.G., et al., Metabolic fate of docosahexaenoic acid (DHA; 22:6n-3) in human cells: direct
retroconversion of DHA to eicosapentaenoic acid (20:5n-3) dominates over elongation to tetracosahexaenoic acid (24:6n-3). FEBS Letters, 2016. 590(18): p. 3188-3194.
162. Broderick, T.L., et al., Biosynthesis of the Essential Fatty Acid Oxidation Cofactor Carnitine Is Stimulated in
Heart and Liver after a Single Bout of Exercise in Mice. Journal of Nutrition and Metabolism, 2018. 2018: p.
7.
163. Monsénégo, J., et al., Enhancing liver mitochondrial fatty acid oxidation capacity in obese mice improves
insulin sensitivity independently of hepatic steatosis. Journal of Hepatology, 2012. 56(3): p. 632-639.
164. van der Heijden, R.A., et al., High-fat diet induced obesity primes inflammation in adipose tissue prior to liver
in C57BL/6j mice. Aging (Albany NY), 2015. 7(4): p. 256-68.
165. Hall, K.D., et al., Ultra-Processed Diets Cause Excess Calorie Intake and Weight Gain: An Inpatient
Randomized Controlled Trial of Ad Libitum Food Intake. Cell Metab, 2019. 30(1): p. 67-77.e3.
166. Kodde, A., et al., Supramolecular structure of dietary fat in early life modulates expression of markers for
mitochondrial content and capacity in adipose tissue of adult mice. Nutr Metab (Lond), 2017. 14: p. 37.
167. Naito, M. and E. Wisse, Filtration effect of endothelial fenestrations on chylomicron transport in neonatal rat
liver sinusoids. Cell Tissue Res, 1978. 190(3): p. 371-82.
168. Bandsma, R.H.J., et al., Acute Inhibition of Glucose-6-Phosphate Translocator Activity Leads to Increased De
Novo Lipogenesis and Development of Hepatic Steatosis Without Affecting VLDL Production in Rats.
Diabetes, 2001. 50(11): p. 2591-2597.
169. Lee, W.N.P., et al., Mass isotopomer analysis: Theoretical and practical considerations. Biological Mass Spectrometry, 1991. 20(8): p. 451-458.
170. Ronda, O.A.H.O., et al., Measurement of Intestinal and Peripheral Cholesterol Fluxes by a Dual-Tracer
Balance Method, in Current Protocols in Mouse Biology. 2016, John Wiley & Sons, Inc.
171. Burcelin, R., et al., Heterogeneous metabolic adaptation of C57BL/6J mice to high-fat diet. American Journal of Physiology-Endocrinology and Metabolism, 2002. 282(4): p. E834-E842.
172. Bharadwaj, K.G., et al., Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in
vivo evidence for receptor- and non-receptor-mediated fatty acid uptake. Journal of Biological Chemistry,
2010. 285(49): p. 37976-37986.
173. Castellano-Castillo, D., et al., Adipose Tissue LPL Methylation is Associated with Triglyceride Concentrations
in the Metabolic Syndrome. Clin Chem, 2018. 64(1): p. 210-218.
174. Kersten, S., Physiological regulation of lipoprotein lipase. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2014. 1841(7): p. 919-933.
175. Xiang, S.-Q., et al., Differential binding of triglyceride-rich lipoproteins to lipoprotein lipase. Journal of Lipid Research, 1999. 40(9): p. 1655-1662.
176. Crawford, S.E. and J. Borensztajn, Plasma clearance and liver uptake of chylomicron remnants generated by
hepatic lipase lipolysis: evidence for a lactoferrin-sensitive and apolipoprotein E-independent pathway.
Journal of Lipid Research, 1999. 40(5): p. 797-805.
177. Schwartz, R.S. and J.D. Brunzell, Increase of adipose tissue lipoprotein lipase activity with weight loss. The Journal of Clinical Investigation, 1981. 67(5): p. 1425-1430.
178. DeLany, J.P., et al., Differential oxidation of individual dietary fatty acids in humans. The American Journal of Clinical Nutrition, 2000. 72(4): p. 905-911.
179. Takada, T., et al., NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin
therapy. Science Translational Medicine, 2015. 7(275): p. 275ra23.
180. Schumacher, M.M., et al., Geranylgeranyl-regulated transport of the prenyltransferase UBIAD1 between
membranes of the ER and Golgi. Journal of lipid research, 2016. 57(7): p. 1286-1299.
181. Akiyama, Y., et al., Comparison of intestinal absorption of vitamin K2 (menaquinone) homologues and their
effects on blood coagulation in rats with hypoprothrombinaemia. Biochem Pharmacol, 1995. 49(12): p.
1801-7.
182. Groenen-van Dooren, M.M., et al., Bioavailability of phylloquinone and menaquinones after oral and
colorectal administration in vitamin K-deficient rats. Biochem Pharmacol, 1995. 50(6): p. 797-801.
183. Hollander, D., E. Rim, and K.S. Muralidhara, Vitamin K1 intestinal absorption in vivo: influence of luminal
contents on transport. Am J Physiol, 1977. 232(1): p. E69-74.
184. Hollander, D. and T.C. Truscott, Colonic absorption of vitamin K-3. The Journal of Laboratory and Clinical Medicine, 1974. 83(4): p. 648-656.
185. Ageno, W., et al., Oral anticoagulant therapy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed:
American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest, 2012. 141(2
Suppl): p. e44S-e88S.
186. Johnson, T.A. and S.R. Pfeffer, Ezetimibe-sensitive cholesterol uptake by NPC1L1 protein does not require
endocytosis. Molecular biology of the cell, 2016. 27(11): p. 1845-1852.
187. Traber, M.G., Vitamin E and K interactions--a 50-year-old problem. Nutr Rev, 2008. 66(11): p. 624-9. 188. Dimova, L.G., et al., Milk cholesterol concentration in mice is not affected by high cholesterol diet- or
genetically-induced hypercholesterolaemia. Scientific Reports, 2018. 8(1): p. 8824.
189. Bligh, E.G. and W.J. Dyer, A rapid method of total lipid extraction and purification. Canadian Journal of Biochemistry and Physiology, 1959. 37(8): p. 911-917.
190. Riphagen, I.J., et al., Prevalence and Effects of Functional Vitamin K Insufficiency: The PREVEND Study. Nutrients, 2017. 9(12).
191. Kwon, H.J., M. Palnitkar, and J. Deisenhofer, The structure of the NPC1L1 N-terminal domain in a closed
conformation. PloS one, 2011. 6(4): p. e18722-e18722.
192. van de Peppel, I.P., et al., Efficient reabsorption of transintestinally excreted cholesterol is a strong
determinant for cholesterol disposal in mice. J Lipid Res, 2019. 60(9): p. 1562-1572.
193. Bruno, E., The prevalence of vitamin K deficiency/insufficiency, and recommendations for increased intake. J Hum Nutr Food Sci, 2016. 4(1): p. 1077.
194. Cesar, T.B., et al., High cholesterol intake modifies chylomicron metabolism in normolipidemic young men. J Nutr, 2006. 136(4): p. 971-6.
195. Festing, M.F.W., Evidence Should Trump Intuition by Preferring Inbred Strains to Outbred Stocks in
Preclinical Research. ILAR Journal, 2014. 55(3): p. 399-404.
196. Kang, S.K., N.A. Hawkins, and J.A. Kearney, C57BL/6J and C57BL/6N substrains differentially influence
phenotype severity in the Scn1a+/− mouse model of Dravet syndrome. Epilepsia Open, 2019. 4(1): p.
164-169.
197. Zurita, E., et al., Genetic polymorphisms among C57BL/6 mouse inbred strains. Transgenic Research, 2011.
20(3): p. 481-489.
198. Ronda, O.A.H.O., et al., Dietary lipid structure in early life does not program fat absorption in later life, in
Journal of Pediatric Gastroenterology and Nutrition. 2018. p. 1095.
199. Nagy, T.R., et al., Effect of Group vs. Single Housing on Phenotypic Variance in C57BL/6J Mice. Obesity Research, 2002. 10(5): p. 412-415.
200. Ronda, O.A.H.O., et al., Relationship between liver size and liver function in mice. Journal of Pediatric Gastroenterology and Nutrition, 2019. 68: p. 750.
201. Millar, J.S., et al., Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with
Triton WR-1339. J Lipid Res, 2005. 46(9): p. 2023-8.
202. Vacha, J., Blood volume in inbred strain BALB/c, CBA/J and C57BL/10 mice determined by means of
59Fe-labelled red cells and 59Fe bound to transferrin. Physiol Bohemoslov, 1975. 24(5): p. 413-9.
203. Nicholson, A., et al., Diet-induced Obesity in Two C57BL/6 Substrains With Intact or Mutant Nicotinamide
Nucleotide Transhydrogenase (Nnt) Gene. Obesity, 2010. 18(10): p. 1902-1905.
A
205. Enguita, M., et al., The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB
and TGFβ pathways in hepatic stellate cells. Cell Death & Disease, 2019. 10(1): p. 14.
206. Ji, S., et al., FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis. Developmental Cell, 2019. 48(4): p. 460-474.e9.
207. Tarasco, E., et al., Phenotypical heterogeneity in responder and nonresponder male ApoE*3Leiden.CETP
mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2018. 315(4): p. G602-G617.
208. Nguyen, K.D., V. Sundaram, and W.S. Ayoub, Atypical causes of cholestasis. World journal of gastroenterology, 2014. 20(28): p. 9418-9426.
209. Kuipers, F., V.W. Bloks, and A.K. Groen, Beyond intestinal soap—bile acids in metabolic control. Nature Reviews Endocrinology, 2014. 10(8): p. 488-498.
210. Boulangé, C.L., et al., Early Metabolic Adaptation in C57BL/6 Mice Resistant to High Fat Diet Induced
Weight Gain Involves an Activation of Mitochondrial Oxidative Pathways. Journal of Proteome Research,
2013. 12(4): p. 1956-1968.
211. Soares, A.F. and H. Lei, Non-invasive diagnosis and metabolic consequences of congenital portosystemic
shunts in C57BL/6 J mice. NMR in Biomedicine, 2018. 31(2): p. e3873.
212. Cudalbu, C., et al., The C57BL/6J mouse exhibits sporadic congenital portosystemic shunts. PloS one, 2013.
8(7): p. e69782-e69782.
213. Paalvast, Y., et al., Male apoE*3-Leiden.CETP mice on high-fat high-cholesterol diet exhibit a biphasic
dyslipidemic response, mimicking the changes in plasma lipids observed through life in men. Physiological
Reports, 2017. 5(19): p. e13376.
214. Wieczorek, A., et al., Megamitochondria formation in hepatocytes of patient with chronic hepatitis C - a case
report. Clinical and experimental hepatology, 2017. 3(3): p. 169-175.
215. Lee, J., et al., The liver is populated by a broad spectrum of markers for macrophages. In alcoholic hepatitis
the macrophages are M1 and M2. Experimental and molecular pathology, 2014. 96(1): p. 118-125.
216. Sheedfar, F., et al., Increased hepatic CD36 expression with age is associated with enhanced susceptibility to
nonalcoholic fatty liver disease. Aging, 2014. 6(4): p. 281-295.
217. Elizondo, A., et al., Polyunsaturated Fatty Acid Pattern in Liver and Erythrocyte Phospholipids from Obese
Patients. Obesity, 2007. 15(1): p. 24-31.
218. Charrez, B., L. Qiao, and L. Hebbard, Hepatocellular carcinoma and non-alcoholic steatohepatitis: The state
of play. World journal of gastroenterology, 2016. 22(8): p. 2494-2502.
219. Thomas, B.A., et al., Plasma fatty acids of neonates born to mothers with and without gestational diabetes. Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005. 72(5): p. 335-341.
220. Riediger, N.D., et al., A Systemic Review of the Roles of n-3 Fatty Acids in Health and Disease. Journal of the American Dietetic Association, 2009. 109(4): p. 668-679.
221. Tuchweber, B., et al., Proliferation and phenotypic modulation of portal fibroblasts in the early stages of
cholestatic fibrosis in the rat. Lab Invest, 1996. 74(1): p. 265-78.
222. Rattay, S., et al., Anti-inflammatory consequences of bile acid accumulation in virus-infected bile duct ligated
mice. PLOS ONE, 2018. 13(6): p. e0199863.
223. Vaz, F.M., et al., Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated
hypercholanemia without a clear clinical phenotype. Hepatology, 2015. 61(1): p. 260-267.
224. Wolters, H., et al., Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo
in mice. Journal of Hepatology, 2002. 37(5): p. 556-563.
225. Lionarons, D.A., J.L. Boyer, and S.-Y. Cai, Evolution of substrate specificity for the bile salt transporter
ASBT (SLC10A2). Journal of Lipid Research, 2012. 53(8): p. 1535-1542.
226. Xiao, Y., et al., Administration of antibiotics contributes to cholestasis in pediatric patients with intestinal
failure via the alteration of FXR signaling. Experimental & molecular medicine, 2018. 50(12): p. 155-155.
227. Ajouz, H., D. Mukherji, and A. Shamseddine, Secondary bile acids: an underrecognized cause of colon
cancer. World journal of surgical oncology, 2014. 12: p. 164-164.
228. Sinha, J., et al., β-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in
enterocytes and cholangiocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology, 2008.
295(5): p. G996-G1003.
229. Sayin, Sama I., et al., Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of
Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist. Cell Metabolism, 2013. 17(2): p. 225-235.
230. Kim, M.S., et al., Repression of Farnesoid X Receptor during the Acute Phase Response. Journal of Biological Chemistry, 2003. 278(11): p. 8988-8995.
231. Thomas, A.M., et al., Genome-wide tissue-specific farnesoid X receptor binding in mouse liver and intestine. Hepatology (Baltimore, Md.), 2010. 51(4): p. 1410-1419.
232. Peng, K.Y., et al., Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease
progression. J Lipid Res, 2018. 59(10): p. 1977-1986.
233. Violante, S., et al., Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is
234. Hotamisligil, G.S., Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease. Cell, 2010. 140(6): p. 900-917.
235. Toyoda, A., et al., Effects of non-purified and semi-purified commercial diets on behaviors, plasma
corticosterone levels, and cecum microbiome in C57BL/6J mice. Neuroscience Letters, 2018. 670: p. 36-40.
236. Bouchard, G., et al., Cholesterol gallstone formation in overweight mice establishes that obesity per se is not
linked directly to cholelithiasis risk. J Lipid Res, 2002. 43(7): p. 1105-13.
237. Heinig, M.J., et al., Energy and protein intakes of breast-fed and formula-fed infants during the first year of
life and their association with growth velocity: the DARLING Study. Am J Clin Nutr, 1993. 58(2): p. 152-61.
238. Shimomura, I., et al., Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear
SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes & Development, 1998. 12(20): p.
3182-3194.
239. Moitra, J., et al., Life without white fat: a transgenic mouse. Genes & Development, 1998. 12(20): p. 3168-3181.
240. Ross, S.R., R.A. Graves, and B.M. Spiegelman, Targeted expression of a toxin gene to adipose tissue:
transgenic mice resistant to obesity. Genes & Development, 1993. 7(7b): p. 1318-1324.
241. Beierle, E.A., et al., Artificial Rearing of Mouse Pups: Development of a Mouse Pup in a Cup Model. Pediatric Research, 2004. 56(2): p. 250-255.
242. Hall, W., Weaning and growth of artificially reared rats. Science, 1975. 190(4221): p. 1313-1315.
243. Hoshiba, J., Method for Hand-feeding Mouse Pups with Nursing Bottles. Journal of the American Association for Laboratory Animal Science, 2004. 43(3): p. 50-53.
244. Yasuda, H., et al., Artificially reared mice exhibit anxiety-like behavior in adulthood. Experimental Animals, 2016. 65(3): p. 267-274.
245. König, B. and H. Markl, Maternal care in house mice. Behavioral Ecology and Sociobiology, 1987. 20(1): p. 1-9.
246. Pinsky, M., et al., Long-lived weight-reduced αMUPA mice show higher and longer maternal-dependent
postnatal leptin surge. PLOS ONE, 2017. 12(11): p. e0188658.
247. Ma, L., et al., Determination of phospholipid concentrations in breast milk and serum using a high
performance liquid chromatography–mass spectrometry–multiple reaction monitoring method. International
Dairy Journal, 2017. 71: p. 50-59.
248. Teegarden, S.L., A.N. Scott, and T.L. Bale, Early life exposure to a high fat diet promotes long-term changes
in dietary preferences and central reward signaling. Neuroscience, 2009. 162(4): p. 924-932.
249. Breij, L.M., et al., An infant formula with large, milk phospholipid-coated lipid droplets containing a mixture
of dairy and vegetable lipids supports adequate growth and is well tolerated in healthy, term infants. Am J
Clin Nutr, 2019. 109(3): p. 586-596.
250. Spiegelman, B.M. and J.S. Flier, Obesity and the Regulation of Energy Balance. Cell, 2001. 104(4): p. 531-543.
251. Butler, A.A. and L.P. Kozak, A recurring problem with the analysis of energy expenditure in genetic models
expressing lean and obese phenotypes. Diabetes, 2010. 59(2): p. 323-329.
252. Kromhout, D., Energy and macronutrient intake in lean and obese middle-aged men (the Zutphen study). Am J Clin Nutr, 1983. 37(2): p. 295-9.
253. JOHNSON, M.L., B.S. BURKE, and J. MAYER, Relative Importance of Inactivity and Overeating in the
Energy Balance of Obese High School Girls. The American Journal of Clinical Nutrition, 1956. 4(1): p.
37-44.
254. STEFANIK, P.A., F.P. HEALD, JR., and J. MAYER, Caloric Intake in Relation to Energy Output of Obese
and Non-Obese Adolescent Boys. The American Journal of Clinical Nutrition, 1959. 7(1): p. 55-62.
255. Maxfield, E. and F. Konishi, Patterns of food intake and physical activity in obesity. Journal of the American Dietetic Association, 1966. 49: p. 406-408.
256. McCarthy, M.C., Dietary and activity patterns of obese women in Trinidad. Journal of the American Dietetic Association, 1966. 48: p. 33-37.
257. Cahn, A., Growth and caloric intake of heavy and tall children. Journal of the American Dietetic Association, 1968. 53: p. 476-480.
258. Lincoln, J.E., Calorie intake, obesity, and physical activity. The American Journal of Clinical Nutrition, 1972.
25(4): p. 390-394.
259. Wilkinson, P.W., et al., Energy intake and physical activity in obese children. British medical journal, 1977.
1(6063): p. 756-756.
260. Lichtman, S.W., et al., Discrepancy between Self-Reported and Actual Caloric Intake and Exercise in Obese
Subjects. New England Journal of Medicine, 1992. 327(27): p. 1893-1898.
261. Heydenreich, J., et al., Total Energy Expenditure, Energy Intake, and Body Composition in Endurance
Athletes Across the Training Season: A Systematic Review. Sports medicine - open, 2017. 3(1): p. 8-8.
262. Westerterp, K.R., Doubly labelled water assessment of energy expenditure: principle, practice, and promise. European Journal of Applied Physiology, 2017. 117(7): p. 1277-1285.
A
263. Prentice, A.M., et al., Energy expenditure in overweight and obese adults in affluent societies: an analysis of
319 doubly-labelled water measurements. Eur J Clin Nutr, 1996. 50(2): p. 93-7.
264. Ravussin, E., et al., Twenty-four-hour energy expenditure and resting metabolic rate in obese, moderately
obese, and control subjects. The American Journal of Clinical Nutrition, 1982. 35(3): p. 566-573.
265. Westerterp, K.R. and J.R. Speakman, Physical activity energy expenditure has not declined since the 1980s
and matches energy expenditures of wild mammals. International Journal of Obesity, 2008. 32(8): p.
1256-1263.
266. Criscuolo, F., et al., Early nutrition and phenotypic development: 'catch-up' growth leads to elevated
metabolic rate in adulthood. Proceedings. Biological sciences, 2008. 275(1642): p. 1565-1570.
267. Nespolo, R.F., L.D. Bacigalupe, and F. Bozinovic, Heritability of energetics in a wild mammal, the leaf-eared
mouse (Phyllotis darwini). Evolution, 2003. 57(7): p. 1679-88.
268. Burton, T., et al., What causes intraspecific variation in resting metabolic rate and what are its ecological
consequences? Proceedings of the Royal Society B: Biological Sciences, 2011. 278(1724): p. 3465-3473.
269. Desai, M. and C.N. Hales, Role of fetal and infant growth in programming metabolism in later life. Biol Rev Camb Philos Soc, 1997. 72(2): p. 329-48.
270. Vickers, M.H., et al., Sedentary behavior during postnatal life is determined by the prenatal environment and
exacerbated by postnatal hypercaloric nutrition. American Journal of Physiology-Regulatory, Integrative and
Comparative Physiology, 2003. 285(1): p. R271-R273.
271. Sutton, G.M., A.V. Centanni, and A.A. Butler, Protein Malnutrition during Pregnancy in C57BL/6J Mice
Results in Offspring with Altered Circadian Physiology before Obesity. Endocrinology, 2010. 151(4): p.
1570-1580.
272. Li, G., et al., Early Postnatal Nutrition Determines Adult Physical Activity and Energy Expenditure in Female
Mice. Diabetes, 2013. 62(8): p. 2773-2783.
273. Goran, M.I. and E.T. Poehlman, Endurance training does not enhance total energy expenditure in healthy
elderly persons. Am J Physiol, 1992. 263(5 Pt 1): p. E950-7.
274. Poehlman, E.T., et al., Effects of Endurance and Resistance Training on Total Daily Energy Expenditure in
Young Women: A Controlled Randomized Trial. The Journal of Clinical Endocrinology & Metabolism, 2002.
87(3): p. 1004-1009.
275. Sun, L., et al., Endurance exercise causes mitochondrial and oxidative stress in rat liver: Effects of a
combination of mitochondrial targeting nutrients. Life Sciences, 2010. 86(1): p. 39-44.
276. Fat and free will. Nature Neuroscience, 2000. 3(11): p. 1057-1057.
277. Levitsky, D.A. and C.R. Pacanowski, Free will and the obesity epidemic. Public Health Nutr, 2012. 15(1): p. 126-41.
278. Rolls, B.J., E.L. Morris, and L.S. Roe, Portion size of food affects energy intake in normal-weight and
overweight men and women. The American Journal of Clinical Nutrition, 2002. 76(6): p. 1207-1213.
279. Diliberti, N., et al., Increased portion size leads to increased energy intake in a restaurant meal. Obes Res, 2004. 12(3): p. 562-8.
280. Jeffery, R.W., et al., Effects of portion size on chronic energy intake. International Journal of Behavioral Nutrition and Physical Activity, 2007. 4(1): p. 27.
281. Rolls, B.J., et al., Increasing the portion size of a packaged snack increases energy intake in men and women. Appetite, 2004. 42(1): p. 63-9.
282. Raynor, H.A. and R.R. Wing, Package unit size and amount of food: do both influence intake? Obesity (Silver Spring), 2007. 15(9): p. 2311-9.
283. Raynor, H.A., et al., Do food provisions packaged in single-servings reduce energy intake at breakfast during
a brief behavioral weight-loss intervention? Journal of the American Dietetic Association, 2009. 109(11): p.
1922-1925.
284. Katz, D.L. and S. Meller, Can We Say What Diet Is Best for Health? Annual Review of Public Health, 2014.
35(1): p. 83-103.
285. Kotite, L., N. Bergeron, and R.J. Havel, Quantification of apolipoproteins B-100, B-48, and E in human
triglyceride-rich lipoproteins. Journal of Lipid Research, 1995. 36(4): p. 890-900.
286. Fraser, R., W.J. Cliff, and F.C. Courtice, THE EFFECT OF DIETARY FAT LOAD ON THE SIZE AND
COMPOSITION OF CHYLOMICRONS IN THORACIC DUCT LYMPH. Quarterly Journal of Experimental
Physiology and Cognate Medical Sciences, 1968. 53(4): p. 390-398.
287. Ong, J.M. and P.A. Kern, Effect of feeding and obesity on lipoprotein lipase activity, immunoreactive protein,
and messenger RNA levels in human adipose tissue. J Clin Invest, 1989. 84(1): p. 305-11.
288. Berman, D.M., et al., Predictors of adipose tissue lipoprotein lipase in middle-aged and older men:
Relationship to leptin and obesity, but not cardiovascular fitness. Metabolism, 1999. 48(2): p. 183-189.
289. Ramis, J.M., et al., Tissue leptin and plasma insulin are associated with lipoprotein lipase activity in severely
obese patients. The Journal of Nutritional Biochemistry, 2005. 16(5): p. 279-285.
290. Donahoo, W.T., et al., Leptin increases skeletal muscle lipoprotein lipase and postprandial lipid metabolism
291. Picard, F., et al., Effects of leptin adipose tissue lipoprotein lipase in the obese ob/ob mouse. Int J Obes Relat Metab Disord, 1998. 22(11): p. 1088-95.
292. Bergo, M., et al., Down-regulation of adipose tissue lipoprotein lipase during fasting requires that a gene,
separate from the lipase gene, is switched on. J Biol Chem, 2002. 277(14): p. 11927-32.
293. Kroupa, O., et al., Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity
in rodent adipose tissue. BMC Physiol, 2012. 12: p. 13.
294. Bäckhed, F., et al., The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences of the United States of America, 2004. 101(44): p. 15718-15723. 295. Péterfy, M., Lipase maturation factor 1: a lipase chaperone involved in lipid metabolism. Biochimica et
biophysica acta, 2012. 1821(5): p. 790-794.
296. Velagapudi, V.R., et al., The gut microbiota modulates host energy and lipid metabolism in mice. Journal of lipid research, 2010. 51(5): p. 1101-1112.
297. Mandard, S., et al., The fasting-induced adipose factor/angiopoietin-like protein 4 is physically associated
with lipoproteins and governs plasma lipid levels and adiposity. J Biol Chem, 2006. 281(2): p. 934-44.
298. Surendran, R.P., et al., Decreased GPIHBP1 protein levels in visceral adipose tissue partly underlie the
hypertriglyceridemic phenotype in insulin resistance. 2018. 13(11): p. e0205858.
299. Beigneux, A.P., et al., Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein
lipase. Arterioscler Thromb Vasc Biol, 2009. 29(6): p. 956-62.
300. Davies, B.S., et al., The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and
chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma. Mol Endocrinol, 2008.
22(11): p. 2496-504.
301. Schoonjans, K., et al., PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional
response via a PPRE in the lipoprotein lipase gene. Embo j, 1996. 15(19): p. 5336-48.
302. Hosseini, M., et al., Transgenic expression and genetic variation of Lmf1 affect LPL activity in mice and
humans. Arterioscler Thromb Vasc Biol, 2012. 32(5): p. 1204-10.
303. Ehrlich, K.C., M. Lacey, and M. Ehrlich, Tissue-specific epigenetics of atherosclerosis-related ANGPT and
ANGPTL genes. Epigenomics, 2019. 11(2): p. 169-186.
304. Theuwissen, E., et al., Vitamin K status in healthy volunteers. Food Funct, 2014. 5(2): p. 229-34. 305. Peyot, M.-L., et al., Beta-cell failure in diet-induced obese mice stratified according to body weight gain:
secretory dysfunction and altered islet lipid metabolism without steatosis or reduced beta-cell mass. Diabetes,
2010. 59(9): p. 2178-2187.
306. Guhad, F., Introduction to the 3Rs (Refinement, Reduction and Replacement). Journal of the American Association for Laboratory Animal Science, 2005. 44(2): p. 58-59.
307. Tkac, I., L. Zacharoff, and J. Dubinsky. Longitudinal study of neurochemical changes in Q140 mouse model
of Huntington’s disease. in 19th Scientific Meeting of the ISMRM. 2011.
308. Emir, U.E., et al., Non-invasive detection of neurochemical changes prior to overt pathology in a mouse
model of spinocerebellar ataxia type 1. Journal of Neurochemistry, 2013. 127(5): p. 660-668.
309. Horder, J., et al., Glutamate and GABA in autism spectrum disorder—a translational magnetic resonance
spectroscopy study in man and rodent models. Translational Psychiatry, 2018. 8(1): p. 106.
310. Rovira, A., J. Alonso, and J. Cordoba, MR imaging findings in hepatic encephalopathy. AJNR Am J Neuroradiol, 2008. 29(9): p. 1612-21.
311. Skoko, J.J., et al., Loss of Nrf2 in mice evokes a congenital intrahepatic shunt that alters hepatic oxygen and
protein expression gradients and toxicity. Toxicol Sci, 2014. 141(1): p. 112-9.
312. Sato, Y., et al., Acute portal hypertension reflecting shear stress as a trigger of liver regeneration following
partial hepatectomy. Surgery Today, 1997. 27(6): p. 518-526.
313. Kummeling, A., et al., Hepatic volume measurements in dogs with extrahepatic congenital portosystemic
shunts before and after surgical attenuation. J Vet Intern Med, 2010. 24(1): p. 114-9.
314. Smith, K.J., et al., Allelic variants of the aryl hydrocarbon receptor differentially influence UVB-mediated
skin inflammatory responses in SKH1 mice. Toxicology, 2018. 394: p. 27-34.
315. Lahvis, G.P., et al., Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon
receptor-deficient mice. Proceedings of the National Academy of Sciences of the United States of America,
2000. 97(19): p. 10442-10447.
316. Walfish, S., A review of statistical outlier methods. Pharmaceutical technology, 2006. 30(11): p. 82. 317. Huang, Y., et al., The pathological effect of Helicobacter pylori infection on liver tissues in mice. Clinical
Microbiology and Infection, 2009. 15(9): p. 843-849.
318. Thoolen, B., et al., Proliferative and Nonproliferative Lesions of the Rat and Mouse Hepatobiliary System. Toxicologic Pathology, 2010. 38(7_suppl): p. 5S-81S.
319. Robertson, S.J., et al., Comparison of Co-housing and Littermate Methods for Microbiota Standardization in
