University of Groningen
Multiple aspects of a plasma cell dyscrasia
de Waal, Elisabeth Geertruida Maria
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Publication date: 2018
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de Waal, E. G. M. (2018). Multiple aspects of a plasma cell dyscrasia. Rijksuniversiteit Groningen.
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Multiple aspects of plasma cell dyscrasia
The financial support for printing this thesis by the University Library of the Rijksuniversiteit Groningen and Stichting ter bevordering van Hematologie Groningen is gratefully acknowledged.
Multiple aspects of plasma cell dyscrasia ©2018 EGM de Waal
ISBN: 978-94-6233-907-1
All rights reserved. No part of this thesis may be reproduced, stored in retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of the author.
Cover design: Lies Benjamin & Esther de Waal Layout: Gildeprint, Enschede, the Netherlands Printed by: Gildeprint, Enschede, the Netherlands
Multiple aspects of plasma cell dyscrasia
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 25 april 2018 om 14.30 uur
door
Elisabeth Geertruida Maria de Waal
geboren op 28 oktober 1977 te Alkmaar
1
Multiple aspects of plasma cell dyscrasia
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 25 april 2018 om 14.30 uur
door
Elisabeth Geertruida Maria de Waal
geboren op 28 oktober 1977
te Alkmaar
Promotores
Prof. dr. E. Vellenga Prof. dr. R.H.J.A. Slart
Beoordelingscommissie
Prof. dr. G.A. Huls Prof. dr. R.A.J.O. Dierckx Prof. dr. S. Zweegman
Paranimfen
Veronica van Aalst – Benedictus Djamila Issa
Content
Chapter 1 General introduction and scope of this thesis 9 Chapter 2 Nuclear medicine imaging of multiple myeloma, particular in 15
the relapsed setting.
(Eur J Nucl Med Mol Imaging. 2017;44:332-341)
Chapter 3 Is [18F]-FDG-PET a better imaging tool than somatostatin receptor 35 scintigraphy in patients with relapsing multiple myeloma?
(Clin Nucl Med. 2012;37:939-942)
Chapter 4 [18F]-FDG-PET increased visibility of bone lesions in relapsed 49 multiple myeloma: Is this hypoxia driven?
(Clin Nucl Med. 2015;40:291-296)
Chapter 5 Combination therapy with bortezomib, continuous low-dose 67 cyclophosphamide and dexamethasone followed by one year of
maintenance treatment for relapsed multiple myeloma patients.
(Br J Haematol. 2015;171:720-725)
Chapter 6 High real-life risk of venous thrombotic events in multiple myeloma: 81 a need for more effective thromboprophylaxis at a lower thrombosis
risk threshold
(submitted)
Chapter 7 Progression of a solitary plasmacytoma to multiple myeloma. 96 A population-based registry of the northern Netherlands.
(Br J Haematol. 2016;175:661-667)
Chapter 8 Thalidomide and dexamethasone followed by autologous 109 stem cell transplantation for scleromyxedema.
(Rheumatology. 2011;50:1925-1926)
Chapter 9 Summary, discussion and future perspective 117 Chapter 10 Nederlandse samenvatting 129
Dankwoord 137
Curriculum vitae 141