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University of Groningen

Multiple aspects of a plasma cell dyscrasia

de Waal, Elisabeth Geertruida Maria

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

de Waal, E. G. M. (2018). Multiple aspects of a plasma cell dyscrasia. Rijksuniversiteit Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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Multiple aspects of plasma cell dyscrasia

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The financial support for printing this thesis by the University Library of the Rijksuniversiteit Groningen and Stichting ter bevordering van Hematologie Groningen is gratefully acknowledged.

Multiple aspects of plasma cell dyscrasia ©2018 EGM de Waal

ISBN: 978-94-6233-907-1

All rights reserved. No part of this thesis may be reproduced, stored in retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of the author.

Cover design: Lies Benjamin & Esther de Waal Layout: Gildeprint, Enschede, the Netherlands Printed by: Gildeprint, Enschede, the Netherlands

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Multiple aspects of plasma cell dyscrasia

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 25 april 2018 om 14.30 uur

door

Elisabeth Geertruida Maria de Waal

geboren op 28 oktober 1977 te Alkmaar

1

Multiple aspects of plasma cell dyscrasia

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

woensdag 25 april 2018 om 14.30 uur

door

Elisabeth Geertruida Maria de Waal

geboren op 28 oktober 1977

te Alkmaar

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Promotores

Prof. dr. E. Vellenga Prof. dr. R.H.J.A. Slart

Beoordelingscommissie

Prof. dr. G.A. Huls Prof. dr. R.A.J.O. Dierckx Prof. dr. S. Zweegman

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Paranimfen

Veronica van Aalst – Benedictus Djamila Issa

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Content

Chapter 1 General introduction and scope of this thesis 9 Chapter 2 Nuclear medicine imaging of multiple myeloma, particular in 15

the relapsed setting.

(Eur J Nucl Med Mol Imaging. 2017;44:332-341)

Chapter 3 Is [18F]-FDG-PET a better imaging tool than somatostatin receptor 35 scintigraphy in patients with relapsing multiple myeloma?

(Clin Nucl Med. 2012;37:939-942)

Chapter 4 [18F]-FDG-PET increased visibility of bone lesions in relapsed 49 multiple myeloma: Is this hypoxia driven?

(Clin Nucl Med. 2015;40:291-296)

Chapter 5 Combination therapy with bortezomib, continuous low-dose 67 cyclophosphamide and dexamethasone followed by one year of

maintenance treatment for relapsed multiple myeloma patients.

(Br J Haematol. 2015;171:720-725)

Chapter 6 High real-life risk of venous thrombotic events in multiple myeloma: 81 a need for more effective thromboprophylaxis at a lower thrombosis

risk threshold

(submitted)

Chapter 7 Progression of a solitary plasmacytoma to multiple myeloma. 96 A population-based registry of the northern Netherlands.

(Br J Haematol. 2016;175:661-667)

Chapter 8 Thalidomide and dexamethasone followed by autologous 109 stem cell transplantation for scleromyxedema.

(Rheumatology. 2011;50:1925-1926)

Chapter 9 Summary, discussion and future perspective 117 Chapter 10 Nederlandse samenvatting 129

Dankwoord 137

Curriculum vitae 141

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Tyrosine

Methionine

LAT1

protein

synthesis

SST

glucose

glucose

pathway

fatty acid

amino acid

sterols

G LUT

VEGF

acetate

TC+

TC+

mitochondria

golgi

nucleus

Ac-Coa

Hypoxia

nitroimidazole

Oxygen

radical

FLT

CXCR4

VLA

VCAM

TK

stromal cell

Choline

CD38

CD138

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