University of Groningen
On the molecular mechanisms of hematopoietic stem cell aging Lazare, Seka Simone
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Publication date: 2018
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Lazare, S. S. (2018). On the molecular mechanisms of hematopoietic stem cell aging. University of Groningen.
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On the molecular mechanisms of
Hematopoietic Stem Cell aging
On the molecular mechanisms of Hematopoietic Stem Cell aging
Cover design by Seka Lazare
ISBN (print version): 978-94-034-0419-6 ISBN (digital version): 978-94-034-0420-2 Copyright © 2018 by Seka Lazare
No parts of this book may be reproduced or transmitted in any form or by any means without permission of the author. All rights reserved.
On the molecular mechanisms of
Hematopoietic Stem Cell aging
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Monday 12 February 2018 at 12.45 hours
by
Seka Simone Lazare
born on 4 June 1988 in Roseau, Dominica
Supervisor
Prof. G. de Haan
Co-supervisor
Dr. L.V. Bystrykh
Assessment Committee
Prof. G.A. Huls Prof. J.N.J. Philipsen Prof. D. Bryder
To my parents, Alick and Myrtle Lazare and my partner, James Corne
Paranymphs
Jakub Wudarski Erik Zwart
Contents
CHAPTER 1 3
General Introduction
Aging of Hematopoietic Stem cells
Blood 2017, in press
CHAPTER 2 23
Genomic and functional integrity of the hematopoietic system requires tolerance of oxidative DNA lesions
Exp Hematol. 2017 53:26-30
CHAPTER 3 59
Lifelong dietary intervention does not affect hematopoietic stem cell function
Exp Hematol. 2017 53:26-30
CHAPTER 4 67
A comprehensive analysis of differentially expressed transcripts during hematopoietic stem cell aging in the mouse
Manuscript in preparation
CHAPTER 5 91
The Neogenin Receptor in Hematopoiesis
Manuscript in preparation
CHAPTER 6 109
Summary and Discussion
APPENDICES 117
Dutch Summary/Nederlandse Samenvatting 118 Acknowledgements 124 Curriculum Vitae 129 List of Publications 130
