University of Groningen
Controlling the self-assembly of amphiphiles using DNA G-quadruplexes
Cozzoli, Liliana
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
Document Version
Publisher's PDF, also known as Version of record
Publication date: 2018
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Cozzoli, L. (2018). Controlling the self-assembly of amphiphiles using DNA G-quadruplexes. University of Groningen.
Copyright
Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).
Take-down policy
If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.
Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.
Controlling the self-assembly
of amphiphiles using DNA
G-quadruplexes
Liliana Cozzoli
The work described in this thesis was carried out at the Stratingh Institute for Chemistry, University of Groningen, the Netherlands.
This work was financially supported by the Zernike Institute for Advanced Materials.
Copyright©2018 L.Cozzoli. All rights reseved. No parts of this book may be reproduced or transmitted in any form or by any means without prior written permission of the author.
Cover design: ©evelienjagtman.com ISBN: 978-94-034-1158-3 (print) ISBN: 978-94-034-1157-6 (digital)
Controlling the self-assembly of
amphiphiles using DNA
G-quadruplexes
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Friday 16 November 2018 at 11.00 hours
by
Liliana Cozzoli
born on 23 June 1987 in Trani, Italy
Supervisors
Prof. J.G. Roelfes Prof. B. PoolmanAssessment Committee
Prof. A. Herrmann Prof. M.D. Witte Prof. E. StulzIn ricordo di zio Raffaele
“Don’t believe what your eyes are telling you. All they show is
limitation. Look with your understanding. Find out what you
already know and you will see the way to fly.”
(Richard Bach, Jonathan Livingston Seagull)
7
Table of Contents
Chapter 1 DNA G-quadruplexes in nanotechnology and
supramolecular chemistry 9
Chapter 2 Responsive DNA G-quadruplex micelles 33 Chapter 3 Design of molecular aptamer beacons for
ATP-triggered cargo release 53
Chapter 4 DNA G-quadruplex templated oligomerization
of a pore forming peptide 77
Chapter 5 Synthesis of photocleavable amphiphiles: toward light-controlled self-assemblies 107
Chapter 6 Conclusion and perspectives 131
Appendices Samenvatting 145
![[Review of: M.I. Santiago (2006) The ecology of oil: Environment, labor, and the Mexican Revolution, 1900-1938] - 300975](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)