University of Groningen Biology of acute myeloid leukemia stem cells Mattes, Katharina

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University of Groningen

Biology of acute myeloid leukemia stem cells

Mattes, Katharina

DOI:

10.33612/diss.98637951

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Publication date:

2019

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Mattes, K. (2019). Biology of acute myeloid leukemia stem cells: the role of CITED2 and mitochondrial

activity. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.98637951

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Katharina Mattes

Biology of acute myeloid

leukemia stem cells

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535611-L-sub01-bw-Mattes

The studies described in this thesis were performed at the Department of Hematology of the University Medical Center Groningen, the Netherlands.

Funding: Printing of this thesis was financially supported by the University of Groningen, the UMCG Graduate School of Medical Science and the Department of Hematology.

ISBN: 978-94-028-1723-2 Cover and layout design: Gerbrig Berger

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Biology of acute myeloid

leukemia stem cells

The role of CITED2 and mitochondrial activity

Proefschrift

ter verkrijging van de graad van doctor aan de

Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. C. Wijmenga

en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op

maandag 4 november 2019 om 14.30 uur

door

Katharina Mattes

geboren op 13 juni 1986

te Mistelbach, Oostenrijk

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Promotor

Prof. dr. E. Vellenga

Copromotor

Dr. H. Schepers

Beoordelingscommissie

Prof. dr. P.J. Coffer

Prof. dr. W. Helfrich

Prof. dr. G. de Haan

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Paranymphs

Aida Rodríguez-López

Gerbrig Berger

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Chapter 1 General introduction

p.9

Chapter 2 CITED2 affects leukemic cell survival by

interfering with p53 activation

(Cell Death & Disease, 2017)

p.31

Chapter 3 The transcriptional regulators CITED2 and PU.1

cooperate in maintaining hematopoietic stem cells

(Experimental Hematology, 2019)

p.53

Chapter 4 Differential redox-regulation and mitochondrial

dynamics in normal and leukemic hematopoietic stem

cells: A potential window for leukemia therapy

(Critical Reviews in Oncology/Hematology, 2019, in

press)

p.79

Chapter 5 CD34

+

_{acute myeloid leukemia cells with low levels}

of reactive oxygen species show increased expression

of stemness-genes and can be targeted by the BCL2

inhibitor Venetoclax

(submitted)

p.109

Chapter 6 Summary, discussion and future perspectives

p.129

Appendices

Dutch summary

Acknowledgements

About the author

List of publications

p.145

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