University of Groningen
Biology of acute myeloid leukemia stem cells
Mattes, Katharina
DOI:
10.33612/diss.98637951
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Publication date: 2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Mattes, K. (2019). Biology of acute myeloid leukemia stem cells: the role of CITED2 and mitochondrial activity. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.98637951
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Katharina Mattes, 2019
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Biology of acute myeloid leukemia stem cells
The role of CITED2 and mitochondrial activity1. The transcriptional co-regulator CITED2 is part of the p53-regulatory network, whose disturbance represents an early event in AML evolution. – this thesis and Abelson et al, Nature, 2018
2. A different mitochondrial content or activity contributes to the phenotypic and functional heterogeneity within the leukemic stem-and progenitor population. - this thesis and Guantes et al, Genome Res., 2015
3. Expression of stem cell-associated transcriptional programs correlates with poor survival of AML patients, which highlights the relevance of leukemia stem cells for disease relapse. – Eppert et al, Nat Med., 2011 and Slush et al, Nature 2017
4. Normal hematopoietic- and leukemic stem cells are very similar regarding their morphology, metabolic activity and gene expression, however, they have an altered dependency on pathways regulating mitochondrial activity and integrity, which represents a therapeutic window. - this thesis; Lagadinou et al, Cell stem cell, 2013 and Pei et al, Cell stem cell, 2018
5. We are like dwarfs sitting on the shoulders of giants; we see more than they did, not because our sight is superior or because we are taller than they, but because they raise us up, and by their great stature add to ours. - based on Bernhard von Chartres, ~1120
6. Improvements in cancer therapy are not achieved by a single person or single research group, but are the result of effective collaborations between scientists, clinicians and pharmaceutical companies.
7. True science thrives best in glass houses where everyone can look in; when the windows are blacked out, as in war, the weeds take over; when secrecy muffles criticism, charlatans and cranks flourish. - Max F. Perutz, Is Science Necessary?: Essays on Science and Scientists, 1989
8. If we hadn’t done it, it would have been done some years later by someone else. We’re not Bach, who, had he not lived, the music would never have been written. - Helen M. Ranney; quoted by H. Franklin Bunn in: The Hematologist: ASH News & Reports, 2008
9. Tanzen macht das Leben schöner.
10. Glattes Eis // Ein Paradies// Für Den, der gut zu tanzen weiß. - Friedrich Nietzsche, Die fröhliche Wissenschafft, 1882
