University of Groningen
Autophagy in normal hematopoiesis and leukemia
Folkerts, Hendrik
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Publication date: 2019
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Folkerts, H. (2019). Autophagy in normal hematopoiesis and leukemia: Biological and therapeutic implications. Rijksuniversiteit Groningen.
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Autophagy in normal hematopoiesis
and leukemia
Biological and therapeutic implications
This research has been funded by the Koningin Wilhelmina Fonds, Nederlandse Kankerbestrijding.
Publication of this thesis was financially supported by the University of Groningen, Graduate school of Medical Sciences, and the Department of Hematology.
ISBN: 978-94-6375-301-2
Cover design: Hendrik Folkerts & Marcel Mousset Lay-out design: Hendrik Folkerts & Marcel Mousset Printing: Ridderprint B.V., www.ridderprint.nl Copyright © 2019, H. Folkerts
All rights reserved. No part of this thesis may be reproduced, stored or transmitted in any form or by any means without permission of the author.
Autophagy in normal
hematopoiesis and leukemia
Biological and therapeutic implications
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op
maandag 25 maart 2019 om 16.15 uur
door
Hendrik Folkerts
geboren op 2 september 1985 te Emmen
Promotores
Prof. dr. E. Vellenga Prof. dr. J.J. Schuringa Prof. dr. P.J. Coffer
Beoordelingscommissie
Prof. dr. I.P. Touw Prof. dr. H.H. Kampinga Prof. dr. J.H.M. van den Berg
Paranimfen
Susan Hilgendorf Martijn Koehorst
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7
General introduction and scope of this thesis The multifaceted role of autophagy in cancer and the micro-environment. Medicinal Research Reviews, 2018; 10.1002/med.21531
Autophagy Proteins ATG5 and ATG7 are essential for the maintenance of human CD34+
hematopoietic Stem-Progenitor cells. Stem Cells, 2016; 34:1651-63
Erythroid progenitors from patients with low-risk myelodysplastic syndromes are dependent on the surrounding micro environment for their survival. Experimental Hematology, 2015; 43:215-22. Inhibition of autophagy as a treatment strategy for p53 wild-type acute myeloid leukemia
Cell Death & Disease, 2017; 8:e2927
Elevated VMP1 expression in acute myeloid leukemia amplifies autophagy and is protective against venetoclax-induced apoptosis.
Submitted
Summary, discussion and future perspectives Nederlandse samenvatting Dankwoord Curriculum Vitae List of publications
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