Cover Page
The handle http://hdl.handle.net/1887/137821 holds various files of this Leiden University dissertation.
Author: Sommer, F.
Title: Chemokine signaling mechanisms underlying inflammation and infection control: Insights from the zebrafish model
Chemokine signaling mechanisms underlying inflammation
and infection control: insights from the zebrafish model
Cover: Illustration of migrating macrophages by Frida Sommer Thesis layout: Frida Sommer
Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op 15 oktober 2020
klokke 11:15 uur door Frida Sommer
Promotor: Prof. dr. Annemarie H. Meijer Co-promotor: Dr. Vincenzo Torraca
Promotiecommissie:
Prof. dr. Gilles P. van Wezel Prof. dr. Roeland M.H. Merks Prof. dr. B. Ewa Snaar-Jagalska Dr. Simone Joosten (LUMC)
Table of contents
Thesis outline 11
General introduction: Chemokine receptors and phagocyte
biology in zebrafish 15
Antagonism between regular and atypical Cxcr3 receptors regulates
macrophage migration during infection and injury in zebrafish 45 Disruption of Cxcr3 chemotactic signaling alters lysosomal function
and renders macrophages more microbicidal 85
Inhibition of macrophage migration in zebrafish demonstrates in vivo
efficacy of human CCR2inhibitors 113
General discussion 135
List of Abbreviations 160
Curriculum vitae 161
