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Drug induced liver injury: assessment of inter-individual variation in the balance of
bioactivation and inactivation as risk factor
den Braver, M.W.
2018
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citation for published version (APA)
den Braver, M. W. (2018). Drug induced liver injury: assessment of inter-individual variation in the balance of
bioactivation and inactivation as risk factor.
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Contents
Chapter 1 9
General introduction and aim of this thesis
Chapter 2 61
Generic method for the absolute quantification of glutathione S-conjugates: application to the conjugates of acetaminophen, clozapine and diclofenac
Chapter 3 89
Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines
Chapter 4 111
Simulation of inter-individual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol
Chapter 5 137
Cytochrome P450 mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases
Chapter 6 169
Reduction of chemically reactive drug metabolites by NAD(P)H:quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 and variability in hepatic concentrations
Chapter 7 197
Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 individuals
Chapter 8 225
Variability in hepatic cytochrome P450 mediated formation and glutathione S-transferase catalyzed detoxification of clozapine and diclofenac derived reactive metabolites in liver homogenates of 20 individuals
Chapter 9 261
Summary, conclusions and future perspective
