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Inter-individual variation in hepatic drug metabolism
den Braver-Sewradj, S.P.
2018
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citation for published version (APA)
den Braver-Sewradj, S. P. (2018). Inter-individual variation in hepatic drug metabolism: The potential of in vitro assays in unraveling the role of metabolism in drug induced liver toxicity.
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Contents
Chapter 1 ... 9
General introduction and aim of this thesis Chapter 2 ... 55
Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer Chapter 3 ... 77
Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors Chapter 4 ... 107
Inter-individual variability in activity of the major drug metabolizing enzymes in liver homogenates of 20 individuals Chapter 5 ... 137
Reduction of chemically reactive drug metabolites by NAD(P)H:quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 and variability in hepatic concentrations Chapter 6 ... 167
Variability in hepatic cytochrome P450 mediated bioactivation and glutathione S-transferase catalyzed detoxification of clozapine and diclofenac derived reactive metabolites in liver homogenates of 20 individuals Chapter 7 ... 203
Amodiaquine quinoneimines induce endoplasmic reticulum stress and apoptosis in HepG2 cells: Evidence for a protective role of glutathione S-transferase P1 Chapter 8 ... 229
