Transgenic mouse models in migraine
Ven, R.C.G. van de
Citation
Ven, R. C. G. van de. (2007, November 6). Transgenic mouse models in migraine. Retrieved from https://hdl.handle.net/1887/12473
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Transgenic Mouse Models
of Migraine
Rob van de Ven
Rob C.G. van de Ven
Transgenic Mouse Models of Migraine
PhD Thesis, Leiden University, 6 November, 2007
ISBN: 978-90-8559-159-7
© Rob C.G. van de Ven except the following chapters:
Chapter 2A Cell Press Chapter 3, 5 Elsevier B.V.
Chapter 6, 7 John Wiley & Sons, Inc.
Chapter 8 American Medical Association
No part of this thesis may be reproduced in any form, by print, photocopy, digital file, internet, or any other means without written permission of the copyright owner.
Printed by: Optima Grafische Communicatie B.V., Rotterdam Cover Design: R. & P. van de Ven
Transgenic Mouse Models of Migraine
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 6 november 2007
klokke 13.45 uur
door
Rob Caspar Gerardus van de Ven geboren te Eindhoven
in 1978
Promotiecommissie
Promotores Prof. dr. M.D. Ferrari Prof. dr. R.R. Frants Copromotor
Dr. A.M.J.M. van den Maagdenberg Referent
Prof. dr. J.H. Meijer Overige Leden
Prof. dr. M.A. van Buchem Prof. dr. G.J. van Ommen
Prof. dr. C.I. de Zeeuw (Erasmus University, Rotterdam)
This work was supported by grants of the Netherlands Organisation for Scientific Research (NWO) (ZonMW 912-02-085 and VICI 918.56.602); By the EU Research Network (grant HPRN-CT-2000-00082 ) and EU sixth framework programme (FP6)
“EUROHEAD” (grant LSHM-CT-2004-504837); and the Centre for Medical Systems Biology (CMSB) established by the Netherlands Genomics Initiative/Netherlands Or- ganisation for Scientific Research (NGI/NWO).
Financial support for the publication of this thesis has been provided by the
J.E. Jurriaanse Stichting, Nederlandse Hoofdpijn Vereniging and Bruker BioSpin BV
Voor Alexandra Voor mijn ouders In memory of Mariann Fodor
Chapter 1 General Introduction 9 Chapter 2 R192Q knockin mouse model:
increased susceptibility to cortical spreading depres- sion and cerebellar MRI abnormalities
39
Chapter 2A A Cacna1a knockin mouse model with increased sus- ceptibility to cortical spreading depression
Neuron. (2004) 41(5):701-10
41
Chapter 2B Morphological assessment in the transgenic R192Q Cacna1a knockin migraine mouse model by in vivo high-resolution MRI
Proceedings of the 3rd IEEE-ISBI, (2006) 406-409
Proceedings of the 14th Intl. Soc. Magn. Reson. Med. (2006) 3391
61
Chapter 3 Gene dosage-dependent transmitter release changes at neuromuscular synapses of Cacna1a R192Q knockin mice are non-progressive and do not lead to morphological changes or muscle weakness
Neuroscience. (2005) 135(1):81-95
71
Chapter 4 FHM1 S218L knockin mouse model to study hemiple- gic migraine, ataxia and mild head trauma-triggered sudden death
In preparation
99
Chapter 5 Characterization of acetylcholine release and the com- pensatory contribution of non-Cav2.1 channels at motor nerve terminals of leaner Cav2.1-mutant mice
Neuroscience. (2007) 144(4):1278-87
125
Chapter 6 Conditional inactivation of the Cacna1a gene in trans- genic mice.
Genesis. (2006) 44(12):589-94
145
Chapter 7 T1 relaxation in in vivo mouse brain at ultra-high field
Magnetic Resonance in Medicine. (2007) 58(2):390-5 157 Chapter 8 Genetic models of migraine
Archives of Neurology. (2007) 64(5):643-6 169
Chapter 9 General Discussion 179
Summary - Samenvatting 195
Curriculum Vitae 207
List of Publications 208
Abbreviations 209
