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Transgenic mouse models in migraine

Ven, R.C.G. van de

Citation

Ven, R. C. G. van de. (2007, November 6). Transgenic mouse models in

migraine. Retrieved from https://hdl.handle.net/1887/12473

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral

thesis in the Institutional Repository of the University

of Leiden

Downloaded from: https://hdl.handle.net/1887/12473

Note: To cite this publication please use the final published version (if

applicable).

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Curriculum Vitae

Curriculum Vitae

Rob Caspar Gerardus van de Ven was born on the 11

th

of June 1978 in Eindhoven, the

Netherlands. He graduated secundary school (Voortgezet Wetenschappelijk Onderwijs)

in 1996 at the Bisschoppelijk College in Weert. In September 1996 he started his

study Biomedical Sciences at the University of Leiden. During this time he did three

research projects. At the department of Neurology (Prof. Dr. R.A.C. Roos ) at the

Leiden University Medical Center he examined the presence of nuclear inclusions in

hippocampus of patients with Huntington’s disease. Subsequently, he studied the insulin

receptor pathway in adipocytes at the department of Molecular Cell Biology (Prof. Dr.

J.A. Maassen) at the Leiden University. His third project was at the Netherlands Cancer

Institute in Amsterdam (Prof. Dr. J.J. Neefjes) and involved the cellular function of

RhoB. He received his Master degree in December 2000. In January 2001 he started

as a PhD-student at the departments of Human Genetics and Neurology at the Leiden

University, under guidance of Dr. A.M.J.M. van den Maagdenberg, Prof. Dr. R.R. Frants

and Prof. Dr. M.D. Ferrari, leading to the results described in this thesis. In January

2006, he started as a postdoc at the Leiden MRM Facilities of the Centre for Medical

Systems Biology (CMSB) under the guidance of Dr. L. van der Weerd and Prof. Dr.

R.R. Frants, where he was involved in implementation of MR techniques to study small

animal models of neurological disease.

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List of Publications

van den Maagdenberg* AMJM, Pietrobon* D, Pizzorusso T, Kaja S, Broos LAM, Cesetti T, van de Ven RCG, Tottene A, van der Kaa J, Plomp JJ, Frants RR, Ferrari MD. A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron. 2004 41(5):701-10.

Bazuine M, van der Zon GC, van de Ven RCG, van den Broek PJ, Antonie Maassen J. Rottlerin inhibits multiple steps involved in insulin-induced glucose uptake in 3T3-L1 adipocytes. Biochem Pharmacol. 2004 68(1):105-12.

Kaja S, van de Ven RCG, Broos LAM, Veldman H, van Dijk JG, Verschuuren JJGM, Frants RR, Ferrari RR, van den Maagdenberg AMJM, Plomp JJ. Gene dosage-dependent transmitter release changes at neuromuscular synapses of Cacna1a R192Q knockin mice are non-progressive and do not lead to morphological changes or muscle weakness. Neuroscience. 2005 135(1):81-95

Kaja S, van de Ven RCG, FerrariMD, FrantsRR, van den MaagdenbergAMJM, Plomp JJ. Compensatory contribution of Cav2.3 channels to acetylcholine release at the neuromuscular junction of tottering mice. J Neurophysiol. 2006 95(4):2698-704.

van de Ven RCG*, Todorov B*, Kaja S, Broos LAM, Plomp JJ, Ferrari MD, Frants RR, van den Maagdenberg AMJM, Conditional inactivation of the Cacna1a gene in transgenic mice. Genesis. 2006 44(12):589-94.

van de Ven RCG*, Kaja S*, Broos LAM, Frants RR, Ferrari MD, van den Maagdenberg AMJM, Plomp JJ.

Characterization of acetylcholine release and the compensatory contribution of non-Cav2.1 channels at motor nerve terminals of leaner Cav2.1-mutant mice. Neuroscience. 2007 144(4):1278-87.

Kaja S, Todorov B, van de Ven RCG, Ferrari MD, Frants RR, van den Maagdenberg AMJM, Plomp JJ.

Redundancy of accessory subunits of Cav2.1 channels in transmitter release at the mouse neuromuscular junction. Brain Res. 2007 1143:92-101.

van de Ven RCG, Kaja S, Plomp JJ, Ferrari MD, Frants RR, van den Maagdenberg AMJM, Genetic models of migraine. Arch Neurol. 2007 64(5):643-6.

Kaja S, van de Ven RCG, van Dijk JG, Verschuuren JJGM, Arahata K, Frants RR, Ferrari MD, van den Maagdenberg AMJM, Plomp JJ. Severely impaired neuromuscular synaptic transmission causes muscle weakness in the Cacna1a mutant mouse rolling Nagoya, Eur J Neurosci. 2007 25(7):2009-20.

van de Ven RCG*, Hogers B*, van den Maagdenberg AMJM, de Groot HJM, Ferrari MD, Frants RR, Poelmann RE, van der Weerd L, Kiihne SH. T1 relaxation in in vivo mouse brain at ultra-high field. Magn Reson Med. 2007 58(2):390-5.

*Autors contributed equally

Publications

208

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Abbreviations

List of Abbreviations

ACh acetylcholine

ωAgaIVA ω-agatoxin-IVA BBB blood-brain barrier

αBTx α-bungarotoxin

Cav1 L-type voltage-gated calcium channel Cav2.1 P/Q-type voltage-gated calcium channel Cav2.2 N-type voltage-gated calcium channel Cav2.3 R-type voltage-gated calcium channel cDNA complementary deoxyribonucleic acid CGRP calcitonin gene-related peptide CMAP compound muscle action potential CNS central nervous system

ωCTxVIA ω-conotoxin-VIA

CSD cortical spreading depression

CSF cerebrospinal fluid

EA2 episodic ataxia type 2 EPP endplate potenetial

ES embryonic stem

FHM familial hemiplegic migraine

FHM1 familial hemiplegic migraine type 1 (caused by mutations in CACNA1A) FHM2 familial hemiplegic migraine type 2 (caused by mutations in ATP1A2) FHM3 familial hemiplegic migraine type 3 (caused by mutations in SCN1A) GABA γ-aminobutyric acid

HEK293 human embryonic kidney 293

KI knockin

KO knockout

Ln leaner

MA migraine with aura

MEPP miniature endplate potential MRI magnetic resonance imaging MRS magnetic resonance spectroscopy

neo neomycin

NMJ neuromuscular junction NMR nuclear magnetic resonance MO migraine without aura PAG periaqueductal grey PBS phosphate buffered saline

PGK-neo neomycin-resistance gene controlled by the phosphoglycerate kinase promoter

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Abbreviations

210

ROI region of interest

RT-PCR reverse transcription polymerase chain reaction SCA6 spinocerebellar ataxia type 6

SNR signal-to-noise ratio SSN superior salivatory nucleus

T tesla

T1 longitudinal or spin-lattice relaxation time T2 transverse or spin-spin relaxation time

TE echo time

TGVS trigeminovascular system TH tyrosine hydroxylase TNC trigeminal nucleus caudalis

TR repetition time

VGCC voltage-gated calcium channel

Referenties

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