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VU Research Portal

Endocrine responsiveness in estrogen receptor-positive breast cancer

Kruger, D.T.

2020

document version

Publisher's PDF, also known as Version of record

Link to publication in VU Research Portal

citation for published version (APA)

Kruger, D. T. (2020). Endocrine responsiveness in estrogen receptor-positive breast cancer: Search for

biomarkers associated with treatment failure.

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Table of contents

Chapter 1 General introduction 9

Chapter 2 Hierarchical clustering of activated proteins in the PI3K and MAPK pathways in ER-positive, HER2-negative breast cancer with potential therapeutic consequences

25

Chapter 3 Hierarchical clustering of PI3K and MAPK pathway proteins in breast cancer intrinsic subtypes 57 Chapter 4 IGF-1R pathway activation as putative biomarker for linsitinib

therapy to revert tamoxifen resistance in ER-positive breast cancer

77

Chapter 5 High ctDNA molecule numbers relate with poor outcome in advanced ER+, HER2- post menopausal breast cancer patients treated with everolimus and exemestane

113

Chapter 6 PI3K pathway protein analyses in metastatic breast cancer patients receiving standard everolimus and exemestane 159 Chapter 7 Summery, General Discussion and Future Perspectives 189 Addendum Nederlandse samenvatting 208

About the author 212

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