Role of reactive oxygen species in rheumatoid arthritis synovial T
lymphocytes
Remans, Philip Herman Jozef
Citation
Remans, P. H. J. (2006, September 12). Role of reactive oxygen species in rheumatoid arthritis synovial T lymphocytes. Retrieved from https://hdl.handle.net/1887/4569 Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in theInstitutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4569
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Acknowledgements
Many contributed to this thesis. In fact, this thesis would not have been written without the help of many people: patients, technicians, secretaries, collegues and co-autors. I am imdebted to each and everyone of you who have contributed to the realisation of this project.
In particular I would like to thank all of my former collegues at the LUMC for their warmth, relativism and encouraging scientific atmosphere. In particular Renee Allaert, who was forcibly subjected to listening to radical theories, while being my roommate, and Jacomien Ravensbergen, whose managerial skills shorten each thesis by a considerable number of years at the Department of Rheumatology in Leiden, and whose human skills made this an agreeable period. Also, I want to express my gratitude to my present collegues in the AMC for giving me the opportunity to perform additional experiments in the best possible scientific environment one can wish for, and making research exciting.
Finally, I wish to express my gratitude to my parents and all of my sisters for your endless patience and equally persisting support.
Curriculum vitae
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List of publications
Fryns JP, Remans PJ, Fabry G. Publication Axial mesodermal dysplasia spectrum: variable symptoms in affected sibs. Am J Med Genet. 1993; 46:736.
Fryns JP, Fabry G, Remans P, Colla P. Progressive anterior vertebral body fusion, overgrowth and distinct craniofacial appearance. Genet Couns. 1993; 4:235-7.
Gringhuis SI, Leow A, Papendrecht-Van Der Voort EA, Remans PH, Breedveld FC, Verweij CL. Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis. J Immunol. 2000; 164:2170-9.
Remans PH, Sont JK, Wagenaar LW, Wouters-Wesseling W, Zuijderduin WM, Jongma A, Breedveld FC, Van Laar JM. Nutrient supplementation with polyunsaturated fatty acids and micronutrients in rheumatoid arthritis: clinical and biochemical effects. Eur J Clin Nutr. 2004; 58:839-45.
Remans PH, Gringhuis SI, van Laar JM, Sanders ME, Papendrecht-van der Voort EA,
Zwartkruis FJ, Levarht EW, Rosas M, Coffer PJ, Breedveld FC, Bos JL, Tak PP, Verweij CL, Reedquist KA. Rap1 signaling is required for suppression of Ras-generated reactive oxygen species and protection against oxidative stress in T lymphocytes. J Immunol. 2004; 173:920-31 Tas SW, Remans PH, Reedquist KA, Tak PP. Signal transduction pathways and transcription factors as therapeutic targets in inflammatory disease: towards innovative antirheumatic therapy. Curr Pharm Des. 2005; 11:581-611
Rowshani AT, Remans P, Rozemuller A, Tak PP. Cerebral vasculitis as a primary manifestation of systemic lupus erythematosus. Ann Rheum Dis. 2005; 64:784-6.
