Preterm birth, early growth and adult metabolic health Finken, M.J.J.

Citation

Finken, M. J. J. (2007, November 22). Preterm birth, early growth and adult

metabolic health. Retrieved from https://hdl.handle.net/1887/12472

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral

thesis in the Institutional Repository of the University

of Leiden

Downloaded from: https://hdl.handle.net/1887/12472

Note: To cite this publication please use the final published version (if

applicable).

BETWEEN

DISEASE

A

.ADINE

*AN -AARTEN

%UROPEAN



 #OULD

!BSTRACT

/BJECTIVES

3TUDIES PUBLISHED ASSESS PERFORM

-ETHODS

! VIEWED

AND

2ESULTS

$ATA RESPECT FOUND TISOL HIGHER TIONS

WAS

#ONCLUSIONS

$IFFERENCES

!LTHOUGH FOUND

½NDINGS ADRENAL DISEASE

CORTISOL



#OULD

)NTRODUCTION

4HERE FACTORS 4HE MENON ADAPTATIONS MENT

RETARDATION

0ATHOLOGICALLY

#USHING´S PAIRED MILDER TARGETS

S BETWEEN OF TION

)N

CIRCULATING ON TEMATICALLY WHETHER

-ETHODS

! IN BINATIONS TITLE WERE INDICATED WEIGHT RELEVANT

4HE

LOWING GESTATIONAL

 #OULD

4ABLE

2EFERENCE 0UBLICATION "IRTH 3EX #ORTISOL NUMBER AUTHOR YEAR AREA WEIGHT AGE

OF GROUPS KG

 0HILLIPS  (ERTFORDSHIRE -   .2 .2 

 $AHLGREN 'yTEBORG^A -&   .2 

!'!^A -&   .2 .2¿

 (OUANG  0ARIS )5'2^B -&  

.ORMAL^B  

 0HILLIPS  (ERTFORDSHIRE &   .2 

 0HILLIPS  0RESTON -&  .2 

 0HILLIPS  !DELAIDE -&  .2 

 ,EVITT  #APE 5&!^C -&   

3OUTH !&!^C -&   

 3ZATHMfRI "UDAPEST^D -&   

.ORMAL^D   

 +AJANTIE  (ELSINKI -&  

 4ENHOLA  +UOPIO 3'!^E -&   …

!'!^E -&   …

 7ALKER  %DINBURGH !'!^F -&   

)5'2^F -&   

.ORMAL^F   

 (ERRICK  ,ANARKSHIRE -&   

'ESTATIONAL .2

 AGE

¿ SIMILAR

ƒ

$E½NITIONS

A3'!

!'!

B)5'2

.ORMAL

C5&!^TH

!&!^THTH

D,"7

.ORMAL

E3'!

!'!

PULATION

F!'!^TH

)5'2^TH

.ORMAL



#OULD

3TATISTICAL

)F PAPERS

WAS ESTIMATED

B

WITH_III NUMBER

Σ

^

Σ

WEIGHT_I

Σ

^

Σ

4HE

SEB

WITH_I

2EGRESSION

  STUDY

2ESULTS

$ESCRIPTION

4HE TEN ABSTRACT

WAS

5+ 

FEMALES CORTISOL HAD ANOTHER INCLUDED ANALYSIS 4ABLE STUDY

Σ

Σ

Σ

Σ

 #OULD

!LTHOUGH TED STUDIES

DE½NITIONS MEAN



BETWEEN PERFORMED

A LEVEL ANALYZED



)N

AND WHOLE EITHER TWEEN REGRESSION OF EXTRACTED CORTISOL AND

3$3 TERINE ESTIMATED POPULATIONS

-ETA ANALYSIS

! CORTISOL

 ADJUSTED OF



OF CIRCULATING

4O

FERENT



#OULD

POPULATIONS LOWER CORTISOL IN

7E

STRENGTH THE

$ISCUSSION

7E BIRTH DED A

)T

RABILITY AREA

BETWEEN PERFORMED CHILDREN IN OLOGICAL ALTERED

4ABLE

STUDY

&IRST †  

LOWER UPPER LOWER UPPER

0HILLIPS     

$AHLGREN     

(OUANG     

0HILLIPS     

0HILLIPS     

,EVITT     

3ZATHMfRI     

+AJANTIE     

4ENHOLA     

7ALKER     

(ERRICK     

!

 #OULD

CHANGE INCLUDED REPORTED FIND SUBSTANTIALLY PERFORMING BETWEEN SIMILAR

&INALLY TING ALSO SION BETWEEN DIFFERENCES STUDY SAME

3TUDIES PARISON METHOD THE

Houang Tenhola Walker Kajantie Philips, Preston Levitt Herrick Dahlgren Philips, Adelaide Szathmari Philips, Hertfordsh Pooled

Study populations by name of first author

-200 -100 0 100 200 Regression coefficient + 95% CI

&IGURE

REGRESSION CONFIDENCE

)NCREASE FOR

#) LATION ORDERED DATA



#OULD Walker

Kajantie

Philips, Preston

Philips, Adelaide

Szathmari

Philips, Hertfordsh

Pooled

Study populations by name of first author

-200 -100 0 100 200

Regression coefficient + 95% CI

Walker

Kajantie

Philips, Preston

Philips, Adelaide

Szathmari

Philips, Hertfordsh

Pooled

Study populations by name of first author

-200 -100 0 100 20

Regression coefficient + 95% CI

&IGURE

REGRESSION CON½DENCE BY

)NCREASE FOR

#) LATION

9 POOLED

&IGURE

&IGURE

 #OULD

ADJUSTED FOR THEIR EARLIER BIRTH

&URTHERMORE MENT CORTISOL WEIGHT

/UR

TIVELY INCLUDED BETWEEN BETWEEN BIRTH IN¾UENCE

(OW

EXPLAINED

INTERCONVERSION SIBLE FROM

Regression coefficient

0 100 200 300 400 500 600 700 Sample size

-80 -60 -40 -20 0 20 40 60

80

&IGURE

COEF½CIENT THE

4HE STUDY ITS



#OULD

(ERTFORDSHIRE LITES LEVELS

  AFTER FROM

!#4(

IN CENT ASSOCIATED

#ONCLUSIONS

0APERS BLISHED STUDIES

WE FINDINGS DEMIOLOGICAL BORN BETWEEN

 (UXLEY SYSTOLIC

 .EWSOME INSULIN

 2ICH %DWARDS COHORT

 (ATTERSLEY LOW

 !NDREW SYNDROME

 2OSMOND LAR

 7ALKER CARDIOVASCULAR

 #OULD

 7ATT

SYSTEM

TENS

 /´2EGAN TION

 %DWARDS BETWEEN

 #LARK FUNCTION

 0HILLIPS WEIGHT

 .ORMAND

 

 &ALL SERUM SHIRE

 +AJANTIE LIFE

 ,EVITT TED CORTISOL

 0HILLIPS TRATIONS

 3ZATHMARI METABOLISM

 4ENHOLA AND



 7ALKER PREMATURE

 

 $AHLGREN DREN

 (ERRICK A OFFSPRING

 (OUANG WITH

 4ENHOLA AND

 

 .IKLASSON STANDARDS

!CTA

 5KKOLA HORMONE

 &ERRARI PATHOPHYSIOLOGICAL

 &INKEN DIMORPHISM

%NDOCRINOL



#OULD

 2EYNOLDS ASSOCIATIONS



 ,UCAS

 

 3AYER OLDER

 &ALL

"-*

 2EYNOLDS BIRTH

 7ARD PITUITARY ADRENAL

 

 "ENEDIKTSSON FOR

 +AJANTIE CORTISOLCORTISONE