Citation
Finken, M. J. J. (2007, November 22). Preterm birth, early growth and adult
metabolic health. Retrieved from https://hdl.handle.net/1887/12472
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral
thesis in the Institutional Repository of the University
of Leiden
Downloaded from: https://hdl.handle.net/1887/12472
Note: To cite this publication please use the final published version (if
applicable).
PRETERM
LONG TERM
-ARTIJN
&RANS
ON
3UBMITTED
!NTENATAL
!BSTRACT
/BJECTIVES
!
AFTER
LIFELONG
FROM
¾AWS
ASSESSED
TREATMENT
IN
-ETHODS
4HERE
3MALL FOR GESTATIONAL AGE
THE
BETAMETHASONE
2ESULTS
.EONATAL
UNEXPOSED
BETAMETHASONE
)N
MLMIN
#ONCLUSIONS
4HE
SONE
ADVERSE
VANT
WOMEN
!NTENATAL
)NTRODUCTION
.EONATAL
FACTORS
EFFECTIVE
)N
ASSOCIATED
SPRING
INSULIN
BY
EXPOSURE
/NE
EXPOSURE
ON
BERTAL
IN
WHEREAS
HIGHER
(OWEVER
BETAMETHASONE
MORTALITY
TER
ON
4HEREFORE
WERE
BETAMETHASONE
AND
-ETHODS
0OPULATION
3UBJECTS
HORT
VERY
.ETHERLANDS
BIRTH
!NTENATAL
)N
USED
POSSIBLE
FROM
ROUTINELY
COULD
RENCE
!T
OF
STUDY
4ABLE 0ERINATAL
BY
#HARACTERISTIC /RIGINAL 0ARTICIPANTS %XPOSED 5NEXPOSED 0 %XPOSED 5NEXPOSED 0
.
'ENERAL
-ALES
7HITES
0ARENTAL A A
/BSTETRIC
-ATERNAL
0ARITY
0ART
(YPERTENSION
'ESTATIONAL
5SE
DURINGB
0ROLONGED
.EONATAL
'ESTATIONAL
"IRTH
,OW
2ESPIRATORY
)NTRACRANIAL
#ONVULSIONS
.ECROTISING
3EPSIS
0OSTNATAL
6ALUES
$ICHOTOMOUSχ
A-ANN 7HITNEY
B3MOKING
!NTENATAL
OR
DED
&URTHERMORE
IN
COMMITTEES
3TUDY
3UBJECTS
CIPATING
OF
!FTER
$"0
#RITIKON
USED
-EAN
SUBSEQUENTLY
SCALE
MEASURED
,ABORATORY
3ERUM
O#
GLUCOSE
AUTOMATED
TRY
MEASURED
SITIVE
M5L
(OMEOSTATIC
)NSULIN
VENOUS
'&2
PER
3TATISTICAL
)N
RACTERISTICS
THEχ
BLES
!NTENATAL
MORTALITY
METHOD
#ONTINUOUS
LINEAR
FOR
OR
4ABLE
LOG
TRANSFORMED
2ESULTS
0ERINATAL
4HE
METHASONE
SOCIO ECONOMIC
)N
DISTRESS
BECAUSE
UTERO
GENDER
4ABLE #HARACTERISTICS
#HARACTERISTIC -EN 7OMEN 0
.
(EIGHT
"-)
7AIST
'LUCOSE
,OG
,OG
4OTAL
($,
,$,
,OG
3"0
$"0
-!0
#REATININ
'&2
6ALUES
!NTENATAL
4ABLE %FFECT
!
/UTCOME !NTENATAL -EAN
EXPOSURE
%XPOSED 5NEXPOSED #RUDE !DJUSTEDA
.
(EIGHT
"-)
7AIST
'LUCOSE
,OG
,OG
4OTAL
($,
,$,
,OG
3"0
$"0
-!0
#REATININ
'&2
6ALUES
A!DJUSTED
"
/UTCOME !NTENATAL -EAN
EXPOSURE
%XPOSED 5NEXPOSED #RUDE !DJUSTEDA
.
(EIGHT
"-)
7AIST
'LUCOSE
,OG
,OG
4OTAL
($,
,$,
,OG
3"0
$"0
-!0
#REATININ
'&2
6ALUES
A!DJUSTED
!NTENATAL
4HE
THE
DIFFERENT
!T
THE
$ATA
!T
A
3"0
TEROL
)N
EXPOSURE
UNEXPOSED
4ABLES
4HESE
CHARACTERISTICS
THESE
INSULIN
!LL
OBSTETRIC
NON HYPERTENSIVE
$ISCUSSION
4HE
OF
VORS
7E
ALTHOUGH
WING
#ONTRARY
FASTING
4HEREFORE
EFFECTS
!NTENATAL
4HERE
LOCATION
WHETHER
WERE
ADJUSTMENT
PLAINED
TIONAL
FROM
THAT
GLUCOCORTICOID
PROGNOSTIC
DIOVASCULAR
3ECOND
CIATIONS
SURE
UNEXPOSED
SEEMS
4HIRD
EXPOSED
4HE
GROUPS
POSED
READILY
TO
THE
EXPOSURE
!
THASONE
MENT
BIRTH
ANTENATAL
FOUND
NIAL
OF
ADDRESS
EXCEPTION
MONTHS
!NTENATAL
GLUCOSE
ASSOCIATIONS
WAS
COSEINSULIN
#ONCLUSIONS
7E
IN¾UENCE
WAS
AGE
WERE
NECESSARY
CORTICOIDS
&IGURE
.
$ASHED OCCURRED MORTALITY
100
90
80
70
60
50
40
30
20
10
0
0 7 14 21 28
Time (days)
Percent survival
Betamethasone exposed
Betamethasone unexposed
!NTENATAL
2EFERENCES
3TOELHORST PRETERM FANTS
2OBERTS OF
"ENEDIKTSSON FOR
-ARTINS
#LIN
.YIRENDA PERMANENTLY EXPRESSION
#ELSI AND
$ODIC EXPOSURE
(OFMAN
+EIJZER 6EEN GROWTH
$OYLE OF
3ECKL
$ESSENS 0EDIATRICS
$ALZIEL THASONE
6ERLOOVE 6ANHORICK IN BIRTH WEIGHT
7ALTHER OF
3CHUTTE INCIDENCE
+EIRSE
%UR
(ILLE 'ROUP
0EDIATRICS
-ATTHEWS MENT
IN
INSULIN
#ONWELL AND
!NTENATAL
#OCKCROFT
3INGH
!4
6ANDENBROUCKE
IN
TION
-OISE WITH
!RCH
AT
"OLUYT REVIEW
,UCAS
"-*
