University of Groningen
The prognostic value of CT radiomic features from primary tumours and pathological lymph
nodes in head and neck cancer patients
Zhai, Tiantian
DOI:
10.33612/diss.111448998
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Zhai, T. (2020). The prognostic value of CT radiomic features from primary tumours and pathological lymph nodes in head and neck cancer patients. University of Groningen. https://doi.org/10.33612/diss.111448998
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The prognostic value of CT radiomic
features from primary tumours and
pathological lymph nodes in head and
neck cancer patients
Zhai, T
The prognostic value of CT radiomic features from primary tumours and pathological lymph nodes in head and neck cancer patients
Thesis, University of Groningen, Groningen, The Netherlands
Printing of this thesis was financially supported by the University of Groningen and the Graduate School of Medical Sciences, UMCG and Elekta B.V..
Cover Siqi Qiu, Tiantian Zhai & Jiani Li
Layout Siqi Qiu & Tiantian Zhai
Printed by Ridderprint I www.ridderprint.nl
ISBN: 978-94-6375-748-5
ISBN (electronic version): 978-94-6375-749-2 © 2020, T Zhai
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording, or otherwise, without prior written permission of the author.
The prognostic value of CT
radiomic features from primary
tumours and pathological lymph
nodes in head and neck cancer
patients
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 15 January 2020 at 12.45 hours
by
Tiantian Zhai
born on 17 August 1987 in Shandong, China
Supervisor
Prof. J.A. Langendijk
Co-supervisors
Dr. R.J.H.M. Steenbakkers Dr. N.M. Sijtsema
Assessment Committee
Prof. J. Pruim
Prof. B.F.A.M. van der Laan Prof. A.L.A.J. Dekker
Dedicated to My Family
谨以此书献给我亲爱的家人
Paranymphs
Lisa van den Bosch Pei Meng
CONTENTS
Chapter 1 General introduction 9
Chapter 2 Improving the prediction of overall survival for head and neck cancer patients using image biomarkers in combination with clinical parameters
19
Chapter 3 The prognostic value of CT-based image-biomarkers for head and neck cancer patients treated with definitive (chemo-) radiation
37
Chapter 4 Pre-treatment radiomic features predict individual lymph
node failure for head and neck cancer patients 59
Chapter 5 External validation of nodal failure prediction models
inclu-ding radiomics in head and neck cancer 91
Chapter 6 Discussion and future perspectives 113
Appendices Chinese summary (中文摘要) 141
Nederlandse samenvatting (Dutch summary) 145 Curriculum vitae 152 List of publications 153 Dankwoord (Acknowledgements) 155
