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University of Groningen The prognostic value of CT radiomic features from primary tumours and pathological lymph nodes in head and neck cancer patients Zhai, Tiantian

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University of Groningen

The prognostic value of CT radiomic features from primary tumours and pathological lymph

nodes in head and neck cancer patients

Zhai, Tiantian

DOI:

10.33612/diss.111448998

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2020

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Zhai, T. (2020). The prognostic value of CT radiomic features from primary tumours and pathological lymph nodes in head and neck cancer patients. University of Groningen. https://doi.org/10.33612/diss.111448998

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(2)

PROPOSITIONS

Belonging to the PhD thesis

The prognostic value of CT radiomic features from primary

tumours and pathological lymph nodes in head and neck cancer

patients

1. Radiomic features extracted from medical images can improve the predictive power of models consisting of classical prognostic factors only. (This thesis) 2. The geometric (irregularity and size) and textural (heterogeneity status) image

features of head and neck squamous cell carcinoma are associated with treatment failure risks. (This thesis)

3. The prediction of specific relapse patterns may guide future treatment intensification targeted on specific high-risk failure patterns, either loco-regional failure, distant metastasis or both. (This thesis)

4. Radiomic features of lymph nodes allow more reliable individual nodal failure prediction than N-stage, opening new opportunities to optimize treatment strategies for each pathological lymph node. (This thesis)

5. Images are more than pictures, they are data. (Robert J. Gillies)

6. For clinical applications, clinical trials need to be conducted to further validate

models.

7. Simple can be harder than complex. You have to work hard to get your thinking clean to make it simple. (Steve Jobs)

8. If you cannot bring the data to the research, you could bring the research to the data. (Andre Dekker)

9. That’s one small step for a man, one giant leap for mankind. (Neil Alden Armstrong).

10. Don’t be afraid to sell yourself, as long as you think you have the talent. (Dale

Carnegie)

Tiantian Zhai Groningen, 2019

PROPOSITIONS

Belonging to the PhD thesis

The prognostic value of CT radiomic features from primary

tumours and pathological lymph nodes in head and neck cancer

patients

1. Radiomic features extracted from medical images can improve the predictive power of models consisting of classical prognostic factors only. (This thesis) 2. The geometric (irregularity and size) and textural (heterogeneity status) image

features of head and neck squamous cell carcinoma are associated with treatment failure risks. (This thesis)

3. The prediction of specific relapse patterns may guide future treatment intensification targeted on specific high-risk failure patterns, either loco-regional failure, distant metastasis or both. (This thesis)

4. Radiomic features of lymph nodes allow more reliable individual nodal failure prediction than N-stage, opening new opportunities to optimize treatment strategies for each pathological lymph node. (This thesis)

5. Images are more than pictures, they are data. (Robert J. Gillies)

6. For clinical applications, clinical trials need to be conducted to further validate

models.

7. Simple can be harder than complex. You have to work hard to get your thinking clean to make it simple. (Steve Jobs)

8. If you cannot bring the data to the research, you could bring the research to the data. (Andre Dekker)

9. That’s one small step for a man, one giant leap for mankind. (Neil Alden Armstrong).

10. Don’t be afraid to sell yourself, as long as you think you have the talent. (Dale

Carnegie)

Tiantian Zhai Groningen, 2019

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