Gut hormones - Novel tools in the treatment of insulin resistance
Parlevliet, E.T.
Citation
Parlevliet, E. T. (2010, October 28). Gut hormones - Novel tools in the treatment of insulin resistance. Retrieved from https://hdl.handle.net/1887/16080
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/16080
Note: To cite this publication please use the final published version (if applicable).
Gut hormones
-
Novel tools in the treatment of insulin resistance
Gut hormones -
Novel tools in the treatment of insulin resistance
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 28 oktober 2010
klokke 15:00 uur
door
Edwin Tijmen Parlevliet
geboren te Katwijk in 1981
Promotiecommissie
Promotor: Prof. Dr. H. Pijl
Overige leden: Prof. Dr. G. van Dijk (UMCG, Groningen) Prof. Dr. Ir. L.M. Havekes
Dr. P.C.N. Rensen Prof. Dr. J.A. Romijn
.
Colophon
© E.T. Parlevliet, 2010. All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any mean, without the prior written permission of the author.
ISBN: 978 94 6108 081 3
Cover illustration:
Terracotta male figure showing intestines. Current location: Allahabad Municipal Museum, Allahabad, Uttar Pradesh, India
Printed by
Gildeprint Drukkerijen, Enschede
Publication of this thesis was financially supported by:
Dutch Diabetes Research Foundation J.E. Jurriaanse Stichting
Novo Nordisk 7TM Pharma A/S
Table of contents
Chapter 1 ... 9 General introduction
Chapter 2 ... 21 Oxyntomodulin ameliorates glucose intolerance in mice fed a high-fat diet
Am J Physiol Endocrinol Metab 2008;294:E142-E147
Chapter 3 ... 35 CNTO736, a novel GLP-1 receptor agonist, ameliorates insulin resistance and inhibits very low density lipoprotein production in high-fat-fed mice
J Pharmacol Exp Ther 2009;328:240-248
Chapter 4 ... 53 GLP-1 Mimetibody, a GLP-1 receptor agonist, decreases VLDL-TG production rate and plasma cholesterol concentration in high-fat-fed APOE*3-Leiden mice
In preparation
Chapter 5 ... 69 GLP-1 treatment reduces endogenous insulin resistance via activation of central GLP-1 receptors in mice fed a high-fat diet
Am J Physiol Endocrinol Metab 2010;299:E318-E324
Chapter 6 ... 85 Obinepitide, a novel Y2/Y4 agonist, and TM30339, a novel Y4 agonist, reduce insulin resistance in high-fat-fed C57Bl/6J mice
In preparation
Chapter 7 ... 101 Summary and conclusions
Samenvatting en conclusies... 111
List of publications ... 121
Curriculum Vitae ... 125
