Insulin sensitivity : modulation by neuropeptides and hormones
Hoek, A.M. van den
Citation
Hoek, A. M. van den. (2006, April 26). Insulin sensitivity : modulation by neuropeptides and hormones. Haveka B.V., Alblasserdam.
Retrieved from https://hdl.handle.net/1887/4372
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of
Leiden
Downloaded from:
https://hdl.handle.net/1887/4372
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The study described in this thesis were perform ed at the Gaubius Laboratories of TNO Quality of Life and the Leiden University M edical Center, Leiden, The Netherlands. The research was financially supported by the Netherlands Organization for Scientific Research (NW O), project 980-10-017.
The printing of this thesis was financially supported by: TNO-Quality of Life, the Gaubius Laboratory
Dutch Diabetes Research Foundation Van Leersum fonds KNAW
Eli Lilly Nederland
Novo Nordisk Farm a B.V. Hope Farm s / abdiets, W oerden
Cover photo: M ieke Roth, 2005. Previously published as cover of Natuurwetenschap & Techniek.
Printed by Haveka B.V., Alblasserdam , The Netherlands
Anita van den Hoek, 2006
Insulin sensitivity
Modulation by neuropeptides and hormones
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus Dr. D. D. Breimer,
hoogleraar in de faculteit der W iskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op woensdag 26 april 2006
klokke 14.15 uur
door
Anita Mariska van den Hoek
Promotiecommissie
Promotores: Prof. dr. L.M. Havekes Prof. dr. J.A. Romijn
Co-promotor: Dr. H. Pijl
Referent: Prof. dr. E. Fliers (AMC, Amsterdam)
Overige leden: Dr. A. Kalsbeek (NIH, Amsterdam) Prof. dr. J.A. Maassen
Contents
Chapter 1.
General introduction
Chapter 2.
Intracerebroventricular Neuropeptide Y infusion precludes inhibition of glucose and VLDL-production by insulin.Diabetes 53:2529-2534, 2004
Chapter 3.
Intracerebroventricular administration of melanotan II increases insulin sensitivity of glucose disposal in mice.Diabetologia 48(8):1621-1626, 2005
Chapter 4.
PYY3-36 reinforces insulin action on glucose disposal in mice fed a high fat diet.
Diabetes 53:1949-1952, 2004
Chapter 5.
Chronic PYY3-36 treatment ameliorates insulin resistance in C57BL6-mice on a high fat diet.
Manuscript in preparation
