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University of Groningen

The public health impact of vaccination programmes in the Netherlands van Wijhe, Maarten

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

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Publication date:

2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

van Wijhe, M. (2018). The public health impact of vaccination programmes in the Netherlands: A historical analysis of mortality, morbidity, and costs. University of Groningen.

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A hi stori cal anal ysi s of mortali ty, morbi di ty, and costs

Maarten van Wi jhe

The publi c health i mpact of vacci nati on programmes i n the Netherlands

M a a rt en va n W ij he Th e p u bl ic h ea lt h i m pa c t o f v a cc in at io n p ro g ra m m es in t he N et he rl a n ds

Ui t nodi gi ng

Voor het bi j wonen van de openbar e ver dedi gi ng van het pr oef s chr i f t

The publ i c heal t h i mpact of vacci nat i on pr ogr ammes i n

t he Net her l ands A hi s

A hi st or i cal anal ysi s of mort al i t y, mor bi di t y, and cost s

door Maart en van Wi j he

Op vr i j dag 14 s ept ember om 11: 00 uur i n het Academi egebouw van de Ri j ks uni ver s i t ei t Gr oni ngen

Br oer s t r aat 5 t e Gr oni ngen Aans l ui t end bent u van har t e wel kom op de r ecept i e t er pl aat s e.

Par ani mf en Wout er van Wi j he

Ni enke van Beek n. van. beek@umcg. nl

Maar t en van Wi j he Rober t J acobs ens vej 80, 4, 2

2300 Kopenhagen

Denemar ken

wi j he@r uc. dk

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The public health impact of vaccination programmes in the Netherlands

A historical analysis of mortality, morbidity, and costs

Maarten van Wijhe

(4)

The work described in this thesis was carried out at the unit of Infectious Disease Modelling, Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), the Netherlands, in collaboration with the unit of Phar- macoTherapy, -Epidemiology and -Economics, Faculty of Science and Engineering, University of Groningen, the Netherlands.

The studies in this thesis were financially supported by The Dutch Ministry of Health, Welfare and Sport.

Financial support for the printing of this thesis was kindly provided by the Univer- sity of Groningen, Research institute SHARE, and the Graduate School of Science and Engineering of the University of Groningen.

ISBN: 978-94-034-0868-2

Printed by: Ridderprint BV, the Netherlands | www.ridderprint.nl Cover design by: Jimmy Pieterson

© M. van Wijhe, 2018

All rights reserved. No part of this publication may be reproduced or transmitted

in any form or by any means without prior permission of the author, or, when

appropriate, the publisher of the publications.

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PhD thesis

to obtain the degree of PhD at the University of Groningen

on the authority of the Rector Magnificus Prof. E. Sterken

and in accordance with the decision by the College of Deans.

This thesis will be defended in public on Friday 14 September 2018 at 11.00 hours

by

Maarten van Wijhe

born on 29 June 1989 in Heumen

The public health impact of vaccination programmes in the Netherlands

A historical analysis of mortality, morbidity, and costs

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Supervisors

Prof. M.J. Postma Prof. J. Wallinga

Assessment Committee

Prof. J.C. Wilschut

Prof. P. Beutels

Prof. E.A.M Sanders

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Paranimphs

Wouter van Wijhe

Nienke van Beek

(8)
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Contents

1 General introduction 1

2 Effect of vaccination programmes on mortality burden among children and young adults in the Netherlands during the 20

th

century: a historical

analysis 19

3 Estimating the population-level effectiveness of vaccination programmes

in the Netherlands 55

4 Years of life lost due to influenza-attributable mortality in older adults in

the Netherlands: a competing risks approach 95

5 Quantifying the impact of mass vaccination programmes on notified cases

in the Netherlands 135

6 Financing vaccination programmes in the Netherlands from a macro-

economic perspective: a historical analysis 169

7 General discussion 193

Supplements 207

Summary . . . 208

Nederlandse samenvatting . . . 212

Acknowledgements . . . 216

About the author . . . 220

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