University of Groningen
New applications of dynamic combinatorial chemistry to medicinal chemistry
Hartman, Alwin
DOI:
10.33612/diss.102259269
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Publication date: 2019
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Citation for published version (APA):
Hartman, A. (2019). New applications of dynamic combinatorial chemistry to medicinal chemistry. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.102259269
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Stellingen
Behorende bij het proefschrift
New applications of dynamic combinatorial chemistry to medicinal
chemistry
van Alwin Hartman
1) You always get experience, no matter what the outcome of your experiment was. 2) Life is an example of induced fit.
3) Slim zijn is relatief, het is hoe hard je voor iets wilt werken.
4) Amplified products in DCC do not necessarily have to be potent binders, as was the case for the hits in Chapter 4.
5) In modelling, do not design too exotic structures: the synthesis should be feasible within a few steps.
6) Flat ligands are boring, venture into less explored chemical space to use the entire volume of a binding pocket.
7) Many scientists are working according the ‘monkey see, monkey do’ principle: imitating or expanding other scientist’s work. We should stop this and as scientists be more creative. (Try something else than click chemistry).
8) Visual inspection of HPLC-chromatograms, for the analysis of DCC experiments like in Chapter 4, can be misleading. Therefore, one should always compare the peak areas.
